Gene: CCDC85A

114800
-
coiled-coil domain containing 85A
protein-coding
2p16.1
Ensembl:ENSG00000055813 Vega:OTTHUMG00000152033 UniprotKB:Q96PX6
NC_000002.12
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.582e-2 (AD)  8.801e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11902680chr2:56384590 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17047868chr2:56382236 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2193488chr2:56381681 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17047859chr2:56373534 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9808416chr2:56336687 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGTB0.954
FGF120.949
STAU20.942
PLCB10.942
TRIM370.939
PNMA20.939
FAM19A20.939
CNTNAP20.939
CDK140.938
SYT130.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.525
HEY2-0.47
SYDE1-0.469
TGIF1-0.468
OR4F5-0.468
CMTM3-0.467
HVCN1-0.466
CHST14-0.463
ARHGEF5-0.463
AGTRAP-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CCDC85A mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CCDC85A mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC85A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC85A mRNA"27188386
D001151ArsenicArsenic results in decreased expression of CCDC85A mRNA19654921
D001280AtrazineAtrazine results in decreased expression of CCDC85A mRNA25929836
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC85A mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CCDC85A mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CCDC85A mRNA28628672
D002737ChloropreneChloroprene results in increased expression of CCDC85A mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CCDC85A gene20938992
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CCDC85A mRNA26033743
D003300CopperCopper deficiency results in increased expression of CCDC85A mRNA26033743
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CCDC85A mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of CCDC85A mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC85A mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CCDC85A mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CCDC85A mRNA28962523
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CCDC85A mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CCDC85A mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of CCDC85A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CCDC85A mRNA21592394
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CCDC85A gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CCDC85A mRNA23649840
C004312glycidolglycidol results in increased expression of CCDC85A mRNA24915197
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of CCDC85A mRNA"26377693
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC85A mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CCDC85A mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC85A mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC85A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CCDC85A mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of CCDC85A mRNA20003209
D007649KetamineKetamine results in decreased expression of CCDC85A mRNA20080153
D007854LeadLead affects the expression of CCDC85A mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CCDC85A gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CCDC85A mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CCDC85A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CCDC85A mRNA"25554681
D009532NickelNickel results in decreased expression of CCDC85A mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CCDC85A mRNA27935865
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CCDC85A mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC85A mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CCDC85A mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of CCDC85A mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CCDC85A mRNA25895662
D053260SootSoot affects the expression of CCDC85A mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CCDC85A mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CCDC85A mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCDC85A mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC85A mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of CCDC85A mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of CCDC85A mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CCDC85A mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of CCDC85A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CCDC85A mRNA24383497
D014635Valproic AcidValproic Acid results in decreased expression of CCDC85A mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal