Gene: OSBPL5

114879
OBPH1|ORP5
oxysterol binding protein like 5
protein-coding
11p15.4
Ensembl:ENSG00000021762 MIM:606733 Vega:OTTHUMG00000011702 UniprotKB:Q9H0X9
NG_009548.1
PubMed|SNP Mapped
3   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.351e-2 (AD)  4.713e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4468331chr11:3144182 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4758533chr11:3128856 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6578322chr11:3121800 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01418188chr11:3145609OSBPL5Gene body6.462e-4Alcohol use disorders26763658
cg07873128chr11:3121400OSBPL51.700e-9Smoking27651444
cg07873128chr11:3121400OSBPL51.360e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM160B20.889
PPIL20.877
HECTD30.871
NDST20.869
APBB30.868
ARRDC10.862
ZGPAT0.862
VPS160.862
CMTR10.861
ZNF760.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.543
OR4F29-0.508
MTRNR2L6-0.401
MTRNR2L9-0.397
MTRNR2L10-0.375
LRRIQ1-0.304
MOGAT2-0.29
KLRC2-0.282
LRAT-0.279
EVC2-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of OSBPL5 mRNA"26377693
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of OSBPL5 mRNA"28433925
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of OSBPL5 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of OSBPL5 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of OSBPL5 mRNA21298039
D001151ArsenicArsenic affects the expression of OSBPL5 mRNA18414638
D001151ArsenicArsenic affects the methylation of OSBPL5 gene25304211
D001280AtrazineAtrazine results in increased expression of OSBPL5 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OSBPL5 mRNA20064835
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of OSBPL5 mRNA20404318
C006780bisphenol Abisphenol A affects the methylation of OSBPL5 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of OSBPL5 promoter27312807
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of OSBPL5 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of OSBPL5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of OSBPL5 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of OSBPL5 mRNA26079696
D002945CisplatinCisplatin results in decreased expression of OSBPL5 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of OSBPL5 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of OSBPL5 mRNA25016146
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of OSBPL5 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of OSBPL5 mRNA21636974
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of OSBPL5 mRNA"28433925
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OSBPL5 mRNA17555576
C069837fullerene C60fullerene C60 results in increased expression of OSBPL5 mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of OSBPL5 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of OSBPL5 mRNA26191083
C544151jinfukangjinfukang results in increased expression of OSBPL5 mRNA27392435
D008727MethotrexateMethotrexate results in decreased expression of OSBPL5 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of OSBPL5 mRNA26011545
C500085muraglitazarmuraglitazar results in decreased expression of OSBPL5 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OSBPL5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OSBPL5 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of OSBPL5 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of OSBPL5 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of OSBPL5 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of OSBPL5 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of OSBPL5 mRNA18301758
C089730rosiglitazonerosiglitazone affects the expression of OSBPL5 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of OSBPL5 mRNA25895662
D013629TamoxifenTamoxifen affects the expression of OSBPL5 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OSBPL5 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of OSBPL5 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of OSBPL5 mRNA17035482
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of OSBPL5 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of OSBPL5 mRNA25729387
D014212TretinoinTretinoin results in increased expression of OSBPL5 mRNA23724009
D014212TretinoinTretinoin results in increased expression of OSBPL5 mRNA16604517
C057693troglitazonetroglitazone results in decreased expression of OSBPL5 mRNA21515302
D014635Valproic AcidValproic Acid results in increased methylation of OSBPL5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of OSBPL5 mRNA17963808
C025643vinclozolinvinclozolin affects the expression of OSBPL5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IDA23934110  26206935  
GO:0005548phospholipid transporter activity-IDA26206935  
GO:0005548phospholipid transporter activity-TAS-  
GO:0008142oxysterol binding-NAS10588946  
GO:0008289lipid binding-IBA21873635  
GO:0015248sterol transporter activity-IBA21873635  
GO:0015485cholesterol binding-IBA21873635  
GO:0015485cholesterol binding-IDA17428193  
GO:0032934sterol binding-IBA21873635  
GO:0070273phosphatidylinositol-4-phosphate binding-IDA26206935  
GO ID GO Term Qualifier Evidence PubMed
GO:0006893Golgi to plasma membrane transport-NAS10588946  
GO:0008203cholesterol metabolic process-NAS10588946  
GO:0015914phospholipid transport-IBA21873635  
GO:0015914phospholipid transport-IDA26206935  
GO:0030301cholesterol transport-NAS10588946  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-NAS10588946  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res