Gene: OSBPL6

114880
ORP6
oxysterol binding protein like 6
protein-coding
2q31.2
Ensembl:ENSG00000079156 MIM:606734 Vega:OTTHUMG00000132579 UniprotKB:Q9BZF3
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.663e-2 (AD)  8.095e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs993598chr2:178317968 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13547053chr2:179184864OSBPL63.780e-16Maternal smoking in pregnancy27040690
cg22057874chr2:179184866OSBPL69.430e-12Maternal smoking in pregnancy27040690
cg19648306chr2:179184854OSBPL62.160e-10Maternal smoking in pregnancy27040690
cg13547053chr2:179184864OSBPL62.110e-18Maternal smoking in pregnancy27040690
cg22057874chr2:179184866OSBPL61.800e-12Maternal smoking in pregnancy27040690
cg19648306chr2:179184854OSBPL61.760e-8Maternal smoking in pregnancy27040690
cg13547053chr2:179184864OSBPL65.460e-17Maternal smoking in pregnancy27040690
cg22057874chr2:179184866OSBPL65.760e-11Maternal smoking in pregnancy27040690
cg19648306chr2:179184854OSBPL61.550e-9Maternal smoking in pregnancy27040690
cg13547053chr2:179184864OSBPL62.100e-11Smoking27651444
cg22057874chr2:179184866OSBPL69.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAST40.89
ACSL30.874
SLC20A10.871
OSBPL30.864
TSC22D20.861
ATP2A20.859
CLASP10.855
SORL10.853
LONP20.852
SFXN10.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.512
SH2D1A-0.487
CTNNA3-0.455
OR4F29-0.455
ANXA13-0.45
TFPI2-0.437
KLF17-0.419
DTHD1-0.411
SNHG18-0.408
SGMS2-0.402

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of OSBPL6 mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of OSBPL6 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of OSBPL6 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of OSBPL6 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of OSBPL6 mRNA21420995
D000447AldehydesAldehydes results in increased expression of OSBPL6 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of OSBPL6 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of OSBPL6 mRNA20458559
C547126AZM551248AZM551248 results in increased expression of OSBPL6 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBPL6 mRNA"20382639
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of OSBPL6 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of OSBPL6 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of OSBPL6 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of OSBPL6 gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSBPL6 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of OSBPL6 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of OSBPL6 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OSBPL6 gene20938992
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of OSBPL6 mRNA18078969
D019327Copper SulfateCopper Sulfate results in increased expression of OSBPL6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased methylation of OSBPL6 promoter27989131
C014347decitabinedecitabine affects the expression of OSBPL6 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSBPL6 mRNA28628672
D002945CisplatinCisplatin affects the expression of OSBPL6 mRNA23300844
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of OSBPL6 promoter27415467
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of OSBPL6 mRNA27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OSBPL6 gene20938992
C039281furanfuran results in decreased expression of OSBPL6 mRNA25539665
C039281furanfuran results in increased methylation of OSBPL6 gene22079235
D019833GenisteinGenistein results in increased expression of OSBPL6 mRNA26865667
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSBPL6 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OSBPL6 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSBPL6 mRNA28628672
C008261lead acetatelead acetate affects the expression of OSBPL6 mRNA21147602
C042720mercuric bromidemercuric bromide results in decreased expression of OSBPL6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OSBPL6 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OSBPL6 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OSBPL6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OSBPL6 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of OSBPL6 mRNA19167457
C046012pentanalpentanal results in increased expression of OSBPL6 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of OSBPL6 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of OSBPL6 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of OSBPL6 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of OSBPL6 mRNA21427059
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of OSBPL6 mRNA25172293
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OSBPL6 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of OSBPL6 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OSBPL6 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of OSBPL6 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of OSBPL6 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OSBPL6 mRNA"26179874
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of OSBPL6 mRNA18078969
D014415TunicamycinTunicamycin results in increased expression of OSBPL6 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of OSBPL6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of OSBPL6 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of OSBPL6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of OSBPL6 mRNA21427059
D014638VanadatesVanadates results in increased expression of OSBPL6 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OSBPL6 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of OSBPL6 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22190034  
GO:0008289lipid binding-IBA21873635  
GO:0008289lipid binding-IEA-  
GO:0015248sterol transporter activity-IBA21873635  
GO:0015248sterol transporter activity-TAS-  
GO:0015485cholesterol binding-IBA21873635  
GO:0032934sterol binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-TAS-  
GO:0015918sterol transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA14593528  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA14593528  
GO:0016020membrane-IBA21873635  
GO:0031965nuclear membrane-IDA14593528  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0097038perinuclear endoplasmic reticulum-IBA21873635  
GO:0097038perinuclear endoplasmic reticulum-IDA14593528  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal