Gene: CGAS

115004
C6orf150|MB21D1|h-cGAS
cyclic GMP-AMP synthase
protein-coding
6q13
Ensembl:ENSG00000164430 MIM:613973 Vega:OTTHUMG00000015034 UniprotKB:Q8N884
NC_000006.12
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.851e-1 (AD)  2.775e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGAS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGAS mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of CGAS mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CGAS mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of CGAS mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CGAS mRNA26079696
D002104CadmiumCadmium results in increased expression of CGAS mRNA24376830
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CGAS mRNA"23811387
C118739entinostatentinostat results in increased expression of CGAS mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGAS mRNA"27188386
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CGAS mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CGAS mRNA24796395
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CGAS mRNA23649840
D009285NaphthoquinonesNaphthoquinones results in increased expression of CGAS mRNA23811387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CGAS mRNA18593933
D010936Plant ExtractsPlant Extracts results in increased expression of CGAS mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of CGAS mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CGAS mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CGAS mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CGAS mRNA28065790
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CGAS mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA23258413  
GO:0003682chromatin binding-IDA28738408  
GO:0003690double-stranded DNA binding-IDA24077100  28363908  
GO:0005515protein binding-IPI26046437  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0061501cyclic-GMP-AMP synthase activity-EXP23258412  
GO:0061501cyclic-GMP-AMP synthase activity-IDA23258413  24077100  26300263  28214358  28363908  28738408  
GO ID GO Term Qualifier Evidence PubMed
GO:0002218activation of innate immune response-IDA23929945  24077100  26046437  28363908  
GO:0002218activation of innate immune response-IMP23258413  
GO:0002230positive regulation of defense response to virus by host-IDA23929945  24077100  26046437  
GO:0002230positive regulation of defense response to virus by host-IMP23258413  
GO:0006974cellular response to DNA damage stimulus-IDA28738408  
GO:0009190cyclic nucleotide biosynthetic process-IDA23258413  24077100  28738408  
GO:0032481positive regulation of type I interferon production-IDA24077100  26046437  28363908  28738408  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0038001paracrine signaling-IDA24077100  
GO:0045087innate immune response-IEA-  
GO:0051607defense response to virus-IDA21478870  23929945  24077100  26046437  
GO:0071360cellular response to exogenous dsRNA-IDA23258413  24077100  28214358  28363908  
GO:2000774positive regulation of cellular senescence-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA23258413  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25603899Common single nucleotide variants underlying drug addiction: more than a decade of research. (2015 Sep)Buhler KMAddict Biol