Gene: NT5C3B

115024
NT5C3L|cN-IIIB
5'-nucleotidase, cytosolic IIIB
protein-coding
17q21.2
Ensembl:ENSG00000141698 Vega:OTTHUMG00000133499 UniprotKB:Q969T7
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
1.547e-1 (AD)  6.980e-1 (ND)   (Frontal_Cortex)
1.747e-1 (AD)  4.594e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BABAM10.957
NDUFA80.956
TUSC20.956
PIN10.956
CDKN2D0.954
NDUFAB10.954
NABP20.953
COX5A0.953
PPP1R70.952
ARF50.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.752
OR4F29-0.697
MAGEA12-0.388
KCNJ15-0.382
FCGR3B-0.373
IL18RAP-0.373
CXCR2-0.372
REST-0.352
CST7-0.351
CXCR1-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NT5C3B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NT5C3B mRNA"21346803
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NT5C3B mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NT5C3B mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of NT5C3B mRNA25181051
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NT5C3B mRNA21266533
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NT5C3B mRNA"20188158
C006253pirinixic acidpirinixic acid results in increased expression of NT5C3B mRNA20813756
D011374ProgesteroneProgesterone affects the expression of NT5C3B mRNA17251523
D018038Sodium SeleniteSodium Selenite results in decreased expression of NT5C3B mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NT5C3B mRNA21570461
D013853ThioacetamideThioacetamide results in decreased expression of NT5C3B mRNA23411599
D014635Valproic AcidValproic Acid affects the expression of NT5C3B mRNA25979313
D014638VanadatesVanadates results in decreased expression of NT5C3B mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NT5C3B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0000287magnesium ion binding-IEA-  
GO:0005515protein binding-IPI20706999  
GO:00082535'-nucleotidase activity-IBA21873635  
GO:00082535'-nucleotidase activityNOTIBA21873635  
GO:00082535'-nucleotidase activity-TAS-  
GO:0016791phosphatase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0009117nucleotide metabolic process-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429958mRNA decay by 3' to 5' exoribonucleaseTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25517131Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses. (2015 Mar 1)Dijkstra AEAm J Respir Crit Care Med