Gene: ATG4A

115201
APG4A|AUTL2
autophagy related 4A cysteine peptidase
protein-coding
Xq22.3
Ensembl:ENSG00000101844 MIM:300663 Vega:OTTHUMG00000022176 UniprotKB:Q8WYN0
NC_000023.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DERL20.838
ZNF1210.821
KDELR20.816
LRRC420.815
G3BP10.812
TXNDC50.806
MITD10.803
COLGALT10.803
TMEM430.802
CDC42SE10.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
OR4F29-0.49
HES5-0.258
RERGL-0.217
EDN3-0.191
TDGF1-0.188
SLC6A2-0.164
FAM180B-0.163
REN-0.161
CRH-0.157

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0259463-methyladenine3-methyladenine results in decreased expression of ATG4A mRNA21681844
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATG4A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATG4A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ATG4A mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ATG4A mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ATG4A mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein]29179951
C006780bisphenol Abisphenol A results in increased expression of ATG4A mRNA25181051
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein]29179951
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of BECN1 protein]29179951
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of CCND1 protein]29179951
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]29179951
D019256Cadmium ChlorideATG4A protein affects the reaction [Cadmium Chloride results in increased expression of MMP9 protein]29179951
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATG4A protein29179951
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATG4A protein29179951
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ATG4A mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of ATG4A mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of ATG4A mRNA25562108
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATG4A mRNA22079256
D017313FenretinideFenretinide results in increased expression of ATG4A mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATG4A mRNA25613284
C544151jinfukangjinfukang results in decreased expression of ATG4A mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of ATG4A mRNA21678067
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of ATG4A mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATG4A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ATG4A mRNA22079256
D015474IsotretinoinIsotretinoin results in decreased expression of ATG4A mRNA20436886
D020123SirolimusSirolimus results in increased expression of ATG4A mRNA21681844
D018038Sodium SeleniteSodium Selenite results in increased expression of ATG4A mRNA18175754
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATG4A mRNA25613284
C057693troglitazonetroglitazone results in increased expression of ATG4A mRNA19140230
D014520UrethaneUrethane results in increased expression of ATG4A mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATG4A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ATG4A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATG4A mRNA23179753|2438349
C111237vorinostatvorinostat results in increased expression of ATG4A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0008234cysteine-type peptidase activity-IDA12473658  15169837  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0006501C-terminal protein lipidation-IBA21873635  
GO:0006508proteolysis-IDA12473658  15169837  
GO:0006612protein targeting to membrane-IBA21873635  
GO:0044804autophagy of nucleus-IBA21873635  
GO:0051697protein delipidation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS12446702  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26061994An intron SNP rs807185 in ATG4A decreases the risk of lung cancer in a southwest Chinese population. (2016 Jul)He QEur J Cancer Prev