Gene: FCRL3

115352
CD307c|FCRH3|IFGP3|IRTA3|SPAP2
Fc receptor like 3
protein-coding
1q23.1
Ensembl:ENSG00000160856 MIM:606510 Vega:OTTHUMG00000019400 UniprotKB:Q96P31
NG_023241.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.216e-1 (AD)  3.170e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL2RB0.896
KLRF10.877
TBX210.863
DPPA40.854
MROH50.85
GADL10.845
GZMA0.838
CD3G0.836
LY90.831
KIR2DS40.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST1-0.457
ADCY2-0.457
CYP46A1-0.456
LGI1-0.455
TMEM56-0.454
GDF10-0.454
CDS1-0.452
FUT9-0.45
C1orf53-0.443
C11orf49-0.439

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FCRL3 mRNA"18648102
D000638AmiodaroneAmiodarone results in increased expression of FCRL3 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FCRL3 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of FCRL3 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of FCRL3 mRNA27523638
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FCRL3 mRNA25613284
D009532NickelNickel results in increased expression of FCRL3 mRNA24768652|2558310
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FCRL3 mRNA25613284
D014635Valproic AcidValproic Acid results in decreased methylation of FCRL3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FCRL3 gene25487561
C088658zoledronic acidzoledronic acid results in increased expression of FCRL3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0019900kinase binding-IPI19843936  
GO:0019902phosphatase binding-IPI19843936  
GO:0019903protein phosphatase binding-IPI12051764  
GO:1990782protein tyrosine kinase binding-IPI12051764  
GO ID GO Term Qualifier Evidence PubMed
GO:0002638negative regulation of immunoglobulin production-IDA23857366  
GO:0030890positive regulation of B cell proliferation-IDA23857366  
GO:0034163regulation of toll-like receptor 9 signaling pathway-IDA23857366  
GO:0043410positive regulation of MAPK cascade-IDA23857366  
GO:0045577regulation of B cell differentiation-IDA23857366  
GO:0050859negative regulation of B cell receptor signaling pathway-IDA19843936  
GO:0050864regulation of B cell activation-IDA23857366  
GO:0090279regulation of calcium ion import-IDA19843936  
GO:1905184positive regulation of protein serine/threonine phosphatase activity-IDA12051764  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0009986cell surface-IDA16849395  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20234359Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis. (2010 May)Kochi YNat Rev Rheumatol
20453439Genetic background of tolerance breakdown in rheumatoid arthritis. (2010)Kochi YNihon Rinsho Meneki Gakkai Kaishi
25421156Role of genetic and non-genetic factors in the etiology of Graves' disease. (2015 Mar)Marino MJ Endocrinol Invest
25231450Thyroid autoimmunity. (2014)Wiersinga WMEndocr Dev