Gene: CISH

1154
BACTS2|CIS|CIS-1|G18|SOCS
cytokine inducible SH2 containing protein
protein-coding
3p21.2
Ensembl:ENSG00000114737 MIM:602441 Vega:OTTHUMG00000156853 UniprotKB:Q9NSE2
NG_023194.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.254e-1 (AD)  8.685e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27589809chr3:50650410CISH1.100e-11Smoking27651444
cg21585138chr3:50645106CISH1.500e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCL20.815
IRF10.79
MYC0.779
ITPKC0.767
SBNO20.763
ARID5A0.752
SOCS30.751
IL15RA0.75
BCL30.746
CDK20.743

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.338
TMEM179-0.331
RERGL-0.318
ACY3-0.312
CASC15-0.303
DLK2-0.297
NEUROD6-0.297
GPR17-0.292
MYADML2-0.291
SNX22-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of CISH mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CISH mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CISH mRNA"21354444|2269881
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CISH mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of CISH mRNA"21920950
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of CISH mRNA15618236
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CISH mRNA"28973690
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of CISH mRNA24140754
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of CISH mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CISH mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CISH mRNA19191707
C0175724-nitrotoluene4-nitrotoluene results in decreased expression of CISH mRNA15618236
D000082AcetaminophenAcetaminophen results in decreased expression of CISH mRNA15618236
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CISH mRNA22129741
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of CISH mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CISH mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CISH mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CISH mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA19737545
C102351apicidinapicidin inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CISH mRNA26377693
D001554BenzeneBenzene results in increased expression of CISH mRNA15929907
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CISH mRNA26377693
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CISH mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CISH mRNA27195522
D004958EstradiolEstradiol results in increased expression of CISH mRNA23019147
D004958EstradiolEstradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]12072388
D004958EstradiolEstradiol results in decreased expression of CISH mRNA19484750
D004958EstradiolEstradiol promotes the reaction [Sulpiride results in increased expression of CISH mRNA]18162529
D004958EstradiolEstradiol results in increased expression of CISH mRNA18162529
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of CISH mRNA18192240
C006780bisphenol Abisphenol A affects the expression of CISH mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CISH mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of CISH mRNA20678512|2301914
C006780bisphenol Abisphenol A affects the expression of CISH mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CISH mRNA28472532
C031180chrysenechrysene results in decreased expression of CISH mRNA26377693
D002922CiguatoxinsCiguatoxins affects the expression of CISH mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of CISH mRNA19549813
D003513CycloheximideCycloheximide results in increased expression of CISH mRNA23237828
D016572CyclosporineCyclosporine affects the expression of CISH mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CISH mRNA23640034|2391405
C007262deoxynivalenoldeoxynivalenol results in increased expression of CISH mRNA19625342
D003907DexamethasoneDexamethasone results in increased expression of CISH mRNA22733784
D002945CisplatinCisplatin results in decreased expression of CISH mRNA22023808
D004041Dietary FatsDietary Fats affects the expression of CISH mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of CISH mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CISH mRNA21318169
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CISH mRNA21318169
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CISH mRNA22129741
D004317DoxorubicinCISH mRNA affects the susceptibility to Doxorubicin16044152
C118739entinostatentinostat inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of CISH mRNA]21233418
D004967EstrogensEstrogens results in increased expression of CISH mRNA21233418
D004967EstrogensEstrogens inhibits the reaction [PRL protein results in increased expression of CISH mRNA]18325991
D004967EstrogensEstrogens results in increased expression of CISH mRNA18325991
D004967EstrogensProgesterone inhibits the reaction [Estrogens results in increased expression of CISH mRNA]18325991
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CISH mRNA18936297
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]12072388
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]12072388
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CISH mRNA17942748
D005054EugenolEugenol results in decreased expression of CISH mRNA15618236
D011345FenofibrateFenofibrate results in decreased expression of CISH mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in decreased expression of CISH mRNA]21318169
C039281furanfuran results in decreased expression of CISH mRNA25539665
D019833GenisteinGenistein results in increased expression of CISH mRNA23019147
D019833GenisteinGenistein inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]12072388
C004312glycidolglycidol results in decreased expression of CISH mRNA24915197
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CISH mRNA15159207
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CISH mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CISH mRNA22129741
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CISH mRNA24435449
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CISH protein24435449
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C045463leflunomideleflunomide results in increased expression of CISH mRNA28988120
D001556LindaneLindane results in decreased expression of CISH mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CISH mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CISH mRNA"19910459
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA21461237
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CISH mRNA21461237
D008070LipopolysaccharidesMelatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]21461237
D008550Melatonin[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA21461237
D008550MelatoninMelatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]21461237
D008550MelatoninMelatonin results in decreased expression of CISH mRNA21461237
D008727MethotrexateMethotrexate results in decreased expression of CISH mRNA24449571
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CISH mRNA22978700
C005223methyleugenolmethyleugenol results in decreased expression of CISH mRNA15618236
C002950methylformamidemethylformamide analog results in decreased expression of CISH mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of CISH mRNA17040096
C030957methylmercury IImethylmercury II results in increased expression of CISH mRNA17905399
D009151Mustard GasMustard Gas results in increased expression of CISH mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CISH mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CISH mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CISH mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CISH mRNA19812364
D009532NickelNickel results in increased expression of CISH mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of CISH mRNA24612858
D009966OrphenadrineOrphenadrine affects the expression of CISH mRNA23665939
D010076OxazepamOxazepam results in decreased expression of CISH mRNA15618236
D000073878Palm OilPalm Oil affects the expression of CISH mRNA19680557
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CISH mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of CISH mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CISH mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of CISH mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CISH mRNA18445702|2081375
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of CISH mRNA]21318169
D059808PolyphenolsPolyphenols results in decreased expression of CISH mRNA16293270
D011374ProgesteroneProgesterone inhibits the reaction [Estrogens results in increased expression of CISH mRNA]18325991
D011374ProgesteroneProgesterone inhibits the reaction [PRL protein results in increased expression of CISH mRNA]18325991
D011441PropylthiouracilPropylthiouracil results in decreased expression of CISH mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]12072388
C488333Ro 65-7199Ro 65-7199 affects the expression of CISH mRNA14610520
D012906SmokeSmoke results in increased expression of CISH mRNA23693141
C017947sodium arsenitesodium arsenite inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]15116095
C016104sodium bichromatesodium bichromate results in increased expression of CISH mRNA24612858
C016104sodium bichromatesodium bichromate results in decreased expression of CISH mRNA25993096
D012999SomanSoman results in increased expression of CISH mRNA19281266
D053260SootSoot results in increased expression of CISH mRNA26551751
C517409statticstattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]26297436
D013469SulpirideEstradiol promotes the reaction [Sulpiride results in increased expression of CISH mRNA]18162529
D013469SulpirideSulpiride results in increased expression of CISH mRNA18162529
C013698tallowtallow affects the expression of CISH mRNA19680557
D013739TestosteroneTestosterone results in decreased expression of CISH mRNA15788153
D013739TestosteroneTestosterone results in increased expression of CISH mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CISH mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CISH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CISH gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CISH mRNA19770486|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CISH mRNA19933214|2597527
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CISH mRNA28065790
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C012589trichostatin Atrichostatin A inhibits the reaction [STAT5A gene mutant form results in increased expression of CISH mRNA]25769527
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CISH mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of CISH mRNA29154799
D014635Valproic AcidValproic Acid inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CISH gene25487561
C025643vinclozolinvinclozolin affects the methylation of CISH gene15933200

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI16273093  24658140  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-NAS9465889  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0035556intracellular signal transduction-NAS10902923  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0046627negative regulation of insulin receptor signaling pathway-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-982772Growth hormone receptor signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18243402Gefitinib (ZD1839): therapy in selected patients with non-small cell lung cancer (NSCLC)? (2008 Jul)Dongiovanni DLung Cancer
21221634The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases. (2011 Feb)Laco JVirchows Arch
27602338Analysis of Epstein Barr Virus Encoded RNA Expression in Nasopharyngeal Carcinoma in North-Eastern India: A Chromogenic in Situ Hybridization Based Study. (2016 Jul)Saikia AIran J Otorhinolaryngol
23672832Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer. (2013 Mar 19)Lin RJJ Otolaryngol Head Neck Surg