Gene: UHRF2

115426
NIRF|RNF107|TDRD23|URF2
ubiquitin like with PHD and ring finger domains 2
protein-coding
9p24.1
Ensembl:ENSG00000147854 MIM:615211 Vega:OTTHUMG00000019521 UniprotKB:Q96PU4
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.991e-1 (AD)  5.830e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNOT20.904
TIAL10.893
TXLNG0.874
PDS5A0.872
RIOK30.865
SMNDC10.862
DHX150.861
TLK20.852
AP4E10.851
MSH60.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.49
OR4F29-0.472
HES5-0.399
NXNL1-0.389
PLA2G5-0.366
RLBP1-0.353
C16orf74-0.35
KCNJ16-0.347
ZNF98-0.343
BTBD17-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of UHRF2 mRNA"19095052
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of UHRF2 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of UHRF2 mRNA"18648102
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of UHRF2 mRNA26424790
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UHRF2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UHRF2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UHRF2 mRNA"20382639
D004958EstradiolEstradiol affects the expression of UHRF2 mRNA22574217
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of UHRF2 mRNA26424790
C006780bisphenol Abisphenol A results in decreased expression of UHRF2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of UHRF2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of UHRF2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of UHRF2 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of UHRF2 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of UHRF2 mRNA20106945|2556210
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of UHRF2 mRNA26424790
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of UHRF2 mRNA28628672
D005839GentamicinsGentamicins results in increased expression of UHRF2 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of UHRF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of UHRF2 mRNA28628672
C045463leflunomideleflunomide results in increased expression of UHRF2 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UHRF2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of UHRF2 mRNA"25620056
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of UHRF2 mRNA19095052
D010936Plant ExtractsPlant Extracts results in increased expression of UHRF2 mRNA23557933
D012293RifampinRifampin results in decreased expression of UHRF2 mRNA24552687
D012715Sesame OilSesame Oil results in increased expression of UHRF2 mRNA29191790
D012834SilverSilver results in increased expression of UHRF2 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UHRF2 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in decreased expression of UHRF2 mRNA27618143
D014241TrichloroethyleneTrichloroethylene results in increased methylation of UHRF2 promoter27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UHRF2 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of UHRF2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of UHRF2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of UHRF2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004842ubiquitin-protein transferase activity-IDA14741369  
GO:0005515protein binding-IPI12176013  15178429  21952639  
GO:0042393histone binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IDA14741369  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0008283cell proliferation-IEP12176013  
GO:0010216maintenance of DNA methylation-IBA21873635  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA14741369  
GO:0030154cell differentiation-IEP12176013  
GO:0051726regulation of cell cycle-TAS14741369  
GO:0051865protein autoubiquitination-IDA14741369  
GO:0071158positive regulation of cell cycle arrest-IDA15178429  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12176013  
GO:0005654nucleoplasm-IDA-  
GO:0005720nuclear heterochromatin-IBA21873635  
GO:0005720nuclear heterochromatin-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23598597The dormant and the fully competent oocyte: comparing the transcriptome of human oocytes from primordial follicles and in metaphase II. (2013 Sep)Grondahl MLMol Hum Reprod