Gene: ALPK2

115701
HAK
alpha kinase 2
protein-coding
18q21.31-q21.32
Ensembl:ENSG00000198796 Vega:OTTHUMG00000132755 UniprotKB:Q86TB3
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.678e-1 (AD)  2.486e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7240666chr18:58481867 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACTC10.562
NRAP0.543
TECRL0.54
XIRP10.53
C10orf1130.519
CTHRC10.518
STEAP40.517
ANKRD10.504
INHBA0.502
LDHAL6B0.498

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
E2F1-0.361
FCHO1-0.331
MYH7B-0.323
SAC3D1-0.322
PPP2R3B-0.321
TMEM121-0.313
TEX29-0.311
ZNF775-0.311
C21orf58-0.31
LRRC45-0.306

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALPK2 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALPK2 mRNA"27291303
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ALPK2 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ALPK2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ALPK2 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ALPK2 gene25435355
D004958EstradiolEstradiol results in decreased expression of ALPK2 mRNA21632981
D004958EstradiolEstradiol results in increased expression of ALPK2 mRNA20106945
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ALPK2 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ALPK2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ALPK2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ALPK2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ALPK2 mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ALPK2 mRNA24374135
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of ALPK2 mRNA18078969
D019327Copper SulfateCopper Sulfate results in increased expression of ALPK2 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of ALPK2 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of ALPK2 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of ALPK2 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased methylation of ALPK2 promoter27989131
D003561CytarabineCytarabine results in decreased expression of ALPK2 mRNA21198554
D000069439DasatinibDasatinib results in increased expression of ALPK2 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ALPK2 mRNA24317228
D003703DemecolcineDemecolcine results in increased expression of ALPK2 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of ALPK2 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ALPK2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ALPK2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ALPK2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ALPK2 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of ALPK2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ALPK2 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ALPK2 mRNA22079256
D011345FenofibrateFenofibrate results in increased expression of ALPK2 mRNA25572481
D005557FormaldehydeFormaldehyde results in increased expression of ALPK2 mRNA23649840
D007545IsoproterenolIsoproterenol results in increased expression of ALPK2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ALPK2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ALPK2 mRNA27392435
C042720mercuric bromidemercuric bromide results in increased expression of ALPK2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ALPK2 mRNA28001369
C029938nickel sulfatenickel sulfate results in decreased expression of ALPK2 mRNA22714537
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of ALPK2 mRNA19074003
C016340o,p'-DDT"o,p'-DDT results in decreased expression of ALPK2 mRNA"18204070
D000073878Palm OilPalm Oil results in decreased expression of ALPK2 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ALPK2 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ALPK2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ALPK2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ALPK2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ALPK2 mRNA23608068
D011794QuercetinQuercetin results in decreased expression of ALPK2 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of ALPK2 mRNA22714537
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ALPK2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ALPK2 mRNA21592394
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of ALPK2 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of ALPK2 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALPK2 mRNA20106945|2163298
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALPK2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of ALPK2 mRNA21934132
C032910triadimefontriadimefon results in decreased expression of ALPK2 mRNA26705709
C012589trichostatin Atrichostatin A results in increased expression of ALPK2 mRNA24935251|2670570
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALPK2 mRNA"26179874
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of ALPK2 mRNA18078969
D014520UrethaneUrethane results in decreased expression of ALPK2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALPK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ALPK2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ALPK2 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of ALPK2 mRNA23034163
D014750VincristineVincristine results in increased expression of ALPK2 mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of ALPK2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal