Gene: CKM

1158
CKMM|CPK-M|M-CK
creatine kinase, M-type
protein-coding
19q13.32
Ensembl:ENSG00000104879 MIM:123310 Vega:OTTHUMG00000181782 UniprotKB:P06732
NC_000019.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.733e-2 (AD)  6.642e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MB0.922
ACTA10.899
TNNI10.882
TNNC10.877
MYL10.877
MYL20.851
TNNI20.809
MYLPF0.792
LMOD20.767
MYH10.763

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FTCD-0.273
HIST1H1A-0.258
CCL27-0.25
TEX29-0.245
ZNF575-0.244
SAC3D1-0.235
PNPLA7-0.227
ZNF835-0.225
UCN-0.225
AOC1-0.224

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00148CreatineSmall Molecule57-00-1Approved|Investigational|NutraceuticalTarget
DB02490(Diaminomethyl-Methyl-Amino)-Acetic AcidSmall MoleculeExperimentalTarget
DB04027D-ArginineSmall Molecule157-06-2ExperimentalTarget
DB13191PhosphocreatineSmall Molecule67-07-2NutraceuticalTarget
ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]"9689591
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of CKM mRNA"28940058
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CKM mRNA"15059925
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CKM mRNA"15215175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CKM mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of CKM mRNA22230336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]9689591
D000111AcetylcysteineAcetylcysteine results in decreased secretion of CKM protein21912612
D020106AcrylamideAcrylamide results in decreased expression of CKM mRNA28606764
D000420AlbuterolAlbuterol results in increased secretion of CKM protein8970440
D000493AllopurinolAllopurinol results in decreased secretion of CKM protein21912612
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CKM mRNA16483693
D047310ApigeninApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein]25557508
C006632arsenic trioxidearsenic trioxide results in increased secretion of CKM protein28054265
C006632arsenic trioxidearsenic trioxide results in increased secretion of [CKM protein binds to CKB protein]28054265
C006632arsenic trioxidearsenic trioxide results in increased expression of CKM mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CKM mRNA22228805
D004958EstradiolEstradiol results in decreased expression of CKM mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of CKM mRNA24465770
C006780bisphenol Abisphenol A results in decreased expression of CKM mRNA18180321|2518105
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA12634122
D002231CarbimazoleCarbimazole results in increased expression of CKM protein2565460
D002330CarmustineCarmustine results in decreased expression of CKM mRNA15980968
D017332Cetirizine[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein25020133
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of CKM mRNA18353800
D017291Clarithromycin[Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein19252767
D002994ClofibrateClofibrate results in decreased expression of CKM mRNA22300585
D003042CocaineCocaine results in increased secretion of [CKB protein binds to CKM protein]12359538
D003300CopperCopper results in increased expression of CKM mRNA18522721
D003300CopperCopper deficiency results in decreased expression of CKM protein18993053
D019327Copper SulfateCopper Sulfate results in decreased expression of CKM mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of CKM mRNA18579281
C029036crocincrocin inhibits the reaction [Diazinon results in increased activity of CKM protein]23523949
C029892cupric chloridecupric chloride results in decreased folding of and results in decreased activity of CKM protein18255152
C029892cupric chlorideDithiothreitol inhibits the reaction [cupric chloride results in decreased folding of and results in decreased activity of CKM protein]18255152
D003474CurcuminCurcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]21378372
D003630DaunorubicinDaunorubicin results in decreased expression of CKM mRNA26537877|2894005
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CKM mRNA23914054
D003907Dexamethasone[Dexamethasone co-treated with IGF1 protein] results in decreased expression of CKM protein22936724
D003907DexamethasoneDexamethasone promotes the reaction [IGF1 protein results in increased expression of CKM mRNA]22936724
D003907DexamethasoneDexamethasone results in decreased expression of CKM protein22936724
D003907DexamethasoneDexamethasone results in increased expression of CKM mRNA22936724
D003976Diazinoncrocin inhibits the reaction [Diazinon results in increased activity of CKM protein]23523949
D003976DiazinonDiazinon results in increased activity of CKM protein23523949
D003976DiazinonVitamin E inhibits the reaction [Diazinon results in increased activity of CKM protein]23523949
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CKM mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CKM mRNA26924002
D004041Dietary Fats[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein25020133
D004041Dietary Fats[fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein25020133
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CKM mRNA28085963
C024629dimethyl phthalatedimethyl phthalate affects the expression of CKM mRNA26924002
D004229DithiothreitolDithiothreitol inhibits the reaction [cupric chloride results in decreased folding of and results in decreased activity of CKM protein]18255152
D004237DiuronDiuron results in decreased expression of CKM mRNA25152437
C067311docetaxel[docetaxel co-treated with Doxorubicin] results in increased expression of CKM protein20457137
D004317DoxorubicinDoxorubicin results in decreased expression of CKM mRNA26537877|2894005
D004317Doxorubicin[docetaxel co-treated with Doxorubicin] results in increased expression of CKM protein20457137
D004317DoxorubicinDoxorubicin results in increased expression of CKM protein16242529
D004317Doxorubicintetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein]16242529
D004317DoxorubicinDoxorubicin results in decreased expression of CKM mRNA9689591
D004317DoxorubicinDoxorubicin results in decreased expression of CKM protein15764680
D000431EthanolEthanol results in increased secretion of CKM protein24296114
D000431EthanolPlant Extracts inhibits the reaction [Ethanol results in increased secretion of CKM protein]24296114
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CKM mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CKM mRNA17942748
C093230fexofenadine[fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein25020133
C069837fullerene C60fullerene C60 affects the expression of CKM mRNA19167457
C039281furanfuran results in decreased expression of CKM mRNA25539665
D005707Gallic AcidGallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]19146839
D019833Genistein[Genistein co-treated with vinclozolin] results in increased expression of CKM mRNA23160963
D005839GentamicinsGentamicins affects the expression of CKM protein18694830
D006108GraphiteGraphite results in increased expression of CKM mRNA27440207
C029424hydrazinehydrazine results in decreased expression of CKM mRNA15282401
D006861Hydrogen Peroxide"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]"9689591
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]9689591
D006861Hydrogen PeroxideCAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]9689591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CKM mRNA9689591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CKM mRNA25613284
D007545IsoproterenolGallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]19146839
D007545IsoproterenolIsoproterenol results in increased expression of [CKM protein binds to CKB protein]22391854
D007545IsoproterenolIsoproterenol results in increased secretion of CKM protein27527349
D007545IsoproterenolIsoproterenol results in increased secretion of [CKM protein binds to CKB protein]19146839
D007545IsoproterenolQuercetin inhibits the reaction [Isoproterenol results in increased secretion of CKM protein]27527349
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA12634122
C008261lead acetateCurcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]21378372
C008261lead acetatelead acetate results in increased expression of CKM mRNA11578147
C008261lead acetatelead acetate results in increased secretion of [CKM protein binds to CKB protein]21378372
D008070LipopolysaccharidesApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein]25557508
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CKM protein25557508
D018021Lithium ChlorideLithium Chloride results in increased expression of CKM mRNA20694829
D008942MitoxantroneMitoxantrone results in decreased expression of CKM mRNA26537877|2894005
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CKM mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CKM mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CKM mRNA"25620056
D009532NickelNickel analog results in increased expression of CKM protein25144474
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CKM mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of CKM protein22363556
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of CKM protein]22363556
D010126OzoneOzone results in decreased expression of CKM mRNA12763052
D052638Particulate MatterParticulate Matter results in increased expression of CKM protein25144474
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CKM mRNA22237054
D010578PetroleumPetroleum affects the expression of CKM mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of CKM mRNA23091169
D010672PhenytoinPhenytoin results in increased expression of CKM protein6682525
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CKM mRNA27935865
D010936Plant ExtractsPlant Extracts affects the expression of [CKM protein binds to CKB protein]21378374
D010936Plant ExtractsPlant Extracts inhibits the reaction [Ethanol results in increased secretion of CKM protein]24296114
D011374ProgesteroneProgesterone results in decreased expression of CKM mRNA19690047
D011374ProgesteroneProgesterone results in increased expression of CKM mRNA20726854
D011794QuercetinQuercetin inhibits the reaction [Isoproterenol results in increased secretion of CKM protein]27527349
D015474IsotretinoinIsotretinoin results in increased expression of CKM protein9747221
D012428RutheniumRuthenium results in decreased activity of CKM protein17109965
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CKM mRNA23806026
D019821Simvastatin[Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein19252767
D019821SimvastatinSimvastatin results in decreased expression of CKM protein8611662
C009277sodium arsenatesodium arsenate results in decreased expression of CKM mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of CKM mRNA16356559
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA12634122
C017947sodium arsenitesodium arsenite affects the expression of CKM mRNA17450228
D012969Sodium FluorideSodium Fluoride affects the expression of CKM mRNA28918527
D053260SootSoot results in increased expression of CKM mRNA26551751
D013096SpermineSpermine results in increased expression of CKM mRNA18673383
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA"18579281
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CKM mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CKM mRNA25613284
C020809tetrathiomolybdatetetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein]16242529
C009495titanium dioxidetitanium dioxide results in decreased expression of CKM mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of CKM mRNA"19682533
D014415TunicamycinTunicamycin results in increased expression of CKM mRNA17127020
C025643vinclozolin[Genistein co-treated with vinclozolin] results in increased expression of CKM mRNA23160963
C025643vinclozolinvinclozolin results in increased expression of CKM mRNA23160963
D014810Vitamin EVitamin E inhibits the reaction [Diazinon results in increased activity of CKM protein]23523949
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CKM mRNA"25208076
D019820Xanthine[Xanthine co-treated with XDH protein] results in decreased expression of CKM protein19464573
D015032ZincZinc results in decreased folding of CKM protein18255152
D015032ZincZinc deficiency results in decreased expression of CKM mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004111creatine kinase activity-TAS-  
GO:0005515protein binding-IPI12972258  21516116  25416956  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006600creatine metabolic process-TAS-  
GO:0016310phosphorylation-IEA-  
GO:0046314phosphocreatine biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71288Creatine metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25555412Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. (2015 Sep)Weng JTComput Biol Med