Gene: DHRS1

115817
SDR19C1
dehydrogenase/reductase 1
protein-coding
14q12
Ensembl:ENSG00000157379 MIM:610410 Vega:OTTHUMG00000029333 UniprotKB:Q96LJ7
NC_000014.9
SNP Mapped
2   ANCO-SNPs
AD
0   
1.901e-1 (AD)  5.829e-1 (ND)   (Frontal_Cortex)
7.698e-2 (AD)  2.883e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2295310chr14:24291049 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4568chr14:24290803 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LEMD20.805
LMF20.795
DUS1L0.787
HDAC60.786
ZFAND2B0.786
RING10.785
DRG20.783
UNC45A0.781
XAB20.781
UCKL10.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.558
MTRNR2L6-0.245
MTRNR2L9-0.239
MTRNR2L10-0.199
KCNK5-0.188
TTLL10-0.188
OR4F16-0.187
TBX4-0.18
MOGAT2-0.173

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DHRS1 mRNA19933214
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to DHRS1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DHRS1 protein]26598702
C0293704-toluidine4-toluidine results in increased expression of DHRS1 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of DHRS1 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen results in increased expression of DHRS1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of DHRS1 mRNA17562736
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DHRS1 protein]26598702
D001280AtrazineAtrazine results in increased expression of DHRS1 mRNA26518232
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DHRS1 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of DHRS1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of DHRS1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DHRS1 mRNA26496021
D002220CarbamazepineCarbamazepine affects the expression of DHRS1 mRNA25979313
D002994ClofibrateClofibrate results in decreased expression of DHRS1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of DHRS1 mRNA19320972|1937684
D009249NADPNADP binds to and results in increased activity of DHRS1 protein25526675
D003474CurcuminCurcumin results in decreased expression of DHRS1 mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of DHRS1 mRNA20106945|2556210
D003976DiazinonDiazinon results in increased methylation of DHRS1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DHRS1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DHRS1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of DHRS1 mRNA27392435
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of DHRS1 mRNA27638505
D004237DiuronDiuron results in increased expression of DHRS1 mRNA21551480
C492448ICG 001ICG 001 results in decreased expression of DHRS1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHRS1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DHRS1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of DHRS1 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of DHRS1 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DHRS1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DHRS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DHRS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DHRS1 mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DHRS1 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DHRS1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DHRS1 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of DHRS1 mRNA21278054
C059514resveratrolresveratrol results in increased expression of DHRS1 protein25505154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHRS1 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHRS1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHRS1 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHRS1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of DHRS1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DHRS1 mRNA22363418
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DHRS1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of DHRS1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of DHRS1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of DHRS1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DHRS1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of DHRS1 mRNA23034163
D014810Vitamin EVitamin E results in increased expression of DHRS1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal