Gene: ADCYAP1

116
PACAP
adenylate cyclase activating polypeptide 1
protein-coding
18p11.32
Ensembl:ENSG00000141433 MIM:102980 Vega:OTTHUMG00000131479 UniprotKB:P18509
NC_000018.10
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.531e-1 (AD)  7.476e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14908653chr18:911900ADCYAP13'UTR7.013e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBLN40.791
PCSK10.789
BDNF0.783
CDH130.777
LINGO20.777
GRIA40.771
PCDH80.77
SERTM10.768
FFAR40.76
NAP1L50.759

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARD8-0.495
REST-0.493
CSAG1-0.491
NFE2-0.489
FAM114A1-0.489
CDA-0.487
CCDC102A-0.48
CLEC2B-0.479
IL3RA-0.475
FAM167B-0.474

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB039882,6-Diamino-Hexanoic Acid AmideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]"18198219
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of ADCYAP1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C0159524-iodo-2,5-dimethoxyphenylisopropylamine"ADCYAP1 gene mutant form promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]"24586556
C0159524-iodo-2,5-dimethoxyphenylisopropylamine"ADCYAP1 gene mutant form results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine"24586556
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ADCYAP1 mRNA17562736
D000143Acids1-Methyl-3-isobutylxanthine promotes the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
D000143AcidsADCYAP1 protein affects the secretion of Acids20388963
D000143AcidsFamotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
D000143AcidsRolipram promotes the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
D000242Cyclic AMP[ADCYAP1 protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMP7733904
D000255Adenosine TriphosphateADCYAP1 protein results in increased secretion of Adenosine Triphosphate18563302
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADCYAP1 mRNA22100608
D019386AlendronateAlendronate affects the expression of ADCYAP1 mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADCYAP1 mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of ADCYAP1 mRNA18585445
D001151ArsenicArsenic affects the methylation of ADCYAP1 gene25304211
C015001arsenitearsenite results in increased methylation of ADCYAP1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of ADCYAP1 mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of ADCYAP1 mRNA18585445
C487081belinostatbelinostat results in increased expression of ADCYAP1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C006780bisphenol Abisphenol A results in decreased expression of ADCYAP1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADCYAP1 mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ADCYAP1 promoter22457795
D002118CalciumCalcium deficiency inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D002118CalciumADCYAP1 protein affects the abundance of Calcium21039959
D002118CalciumADCYAP1 protein results in increased abundance of Calcium18198219
D002118CalciumCalcium affects the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]18198219
D002118CalciumSELENOT protein affects the reaction [ADCYAP1 protein results in increased abundance of Calcium]18198219
D002211Capsaicin"Capsaicin inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
D002245Carbon Dioxide[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein28506824
D002245Carbon DioxideNicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]28506824
D002330CarmustineCarmustine results in decreased expression of ADCYAP1 mRNA15980968
D002395Catecholamines1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D002395CatecholaminesADCYAP1 protein modified form results in increased secretion of Catecholamines12183654
D002395CatecholaminesCalcium deficiency inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D002395CatecholaminesEconazole inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D002395CatecholaminesNicardipine inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D002395CatecholaminesNifedipine inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
D004390ChlorpyrifosChlorpyrifos results in increased expression of ADCYAP1 mRNA17452286
D002994ClofibrateClofibrate results in increased expression of ADCYAP1 mRNA17585979
D005576ColforsinColforsin results in decreased activity of ADCYAP1 protein alternative form16847435
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of ADCYAP1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of ADCYAP1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of ADCYAP1 mRNA26577399
D003520CyclophosphamideCyclophosphamide affects the expression of ADCYAP1 mRNA18563302
D003520CyclophosphamideCyclophosphamide results in increased expression of ADCYAP1 protein10754506|9776515
D016572CyclosporineCyclosporine results in decreased methylation of ADCYAP1 promoter27989131
D003976DiazinonDiazinon results in increased expression of ADCYAP1 mRNA17452286
D004041Dietary FatsDietary Fats results in increased expression of ADCYAP1 mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of ADCYAP1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of ADCYAP1 mRNA26033743
D004464EconazoleEconazole inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
C118739entinostatentinostat results in decreased expression of ADCYAP1 mRNA27188386
C007366erythritol anhydrideerythritol anhydride results in decreased expression of ADCYAP1 mRNA12242682
D000431EthanolEthanol results in decreased expression of ADCYAP1 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of ADCYAP1 mRNA]"20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ADCYAP1 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADCYAP1 mRNA17108234
D015738FamotidineFamotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
C039281furanfuran results in decreased expression of ADCYAP1 mRNA25539665
C039281furanfuran results in increased expression of ADCYAP1 mRNA25539665
D019004GalaninGalanin inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineADCYAP1 protein results in increased secretion of Histamine11164953
D006632HistamineDinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineGalanin inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineIL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineMisoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineSST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D006632HistamineTNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
C029424hydrazinehydrazine results in decreased expression of ADCYAP1 mRNA15282401
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"14662737
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"Capsaicin inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine promotes the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
D007649KetamineKetamine results in decreased expression of ADCYAP1 mRNA20080153
D007854LeadLead affects the expression of ADCYAP1 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of ADCYAP1 mRNA22613225
D008727MethotrexateMethotrexate affects the expression of ADCYAP1 mRNA18502557
D0156551-Methyl-4-phenylpyridiniumADCYAP1 protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D016595MisoprostolMisoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]18198219
D009529NicardipineNicardipine inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
C022838nickel chloridenickel chloride results in decreased activity of ADCYAP1 protein22009744
C022838nickel chloridenickel chloride inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]18198219
D009538NicotineNicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]28506824
D009543NifedipineNifedipine inhibits the reaction [ADCYAP1 protein modified form results in increased secretion of Catecholamines]12183654
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of ADCYAP1 mRNA]"20655511
D016627OxidopamineADCYAP1 protein results in decreased susceptibility to Oxidopamine23500093
D020866omega-Conotoxin GVIA"omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]"14662737
D010100Oxygen[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein28506824
D010100OxygenNicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]28506824
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ADCYAP1 mRNA26272509
D010269ParaquatADCYAP1 protein results in decreased susceptibility to Paraquat23500093
D015232DinoprostoneDinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]11164953
D010634PhenobarbitalPhenobarbital affects the expression of ADCYAP1 mRNA19136022
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ADCYAP1 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of ADCYAP1 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of ADCYAP1 mRNA17950772
D059808PolyphenolsPolyphenols results in decreased expression of ADCYAP1 mRNA16293270
D011374ProgesteroneADCYAP1 protein results in increased abundance of Progesterone19926922
C428725pyridabenpyridaben results in increased expression of ADCYAP1 mRNA22563483
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ADCYAP1 mRNA16079270
D020889RolipramRolipram promotes the reaction [ADCYAP1 protein affects the secretion of Acids]20388963
D020889RolipramRolipram results in decreased activity of ADCYAP1 protein alternative form16847435
D012402RotenoneADCYAP1 protein modified form inhibits the reaction [Rotenone results in increased activity of CASP3 protein]16004991
D012402RotenoneRotenone results in decreased expression of ADCYAP1 mRNA19013527
D043343Testosterone PropionateTestosterone Propionate results in increased expression of ADCYAP1 mRNA19427307
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of ADCYAP1 mRNA19465110
D014635Valproic AcidValproic Acid affects the expression of ADCYAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ADCYAP1 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of ADCYAP1 mRNA24383497
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADCYAP1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCYAP1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of ADCYAP1 mRNA27188386
C111237vorinostatvorinostat results in increased expression of ADCYAP1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI7680413  
GO:0005184neuropeptide hormone activity-IBA21873635  
GO:0005184neuropeptide hormone activity-IDA23800469  
GO:0005515protein binding-IPI17470806  25451228  
GO:0016521pituitary adenylate cyclase activating polypeptide activity-IBA21873635  
GO:0016521pituitary adenylate cyclase activating polypeptide activity-IDA9603988  
GO:0031858pituitary adenylate cyclase-activating polypeptide receptor binding-IBA21873635  
GO:0031858pituitary adenylate cyclase-activating polypeptide receptor binding-IEA-  
GO:0051428peptide hormone receptor binding-IBA21873635  
GO:0051428peptide hormone receptor binding-IDA11175907  
GO:0051428peptide hormone receptor binding-IPI17470806  
GO ID GO Term Qualifier Evidence PubMed
GO:0001541ovarian follicle development-IBA21873635  
GO:0001541ovarian follicle development-IEA-  
GO:0001662behavioral fear response-IBA21873635  
GO:0001662behavioral fear response-IEA-  
GO:0001821histamine secretion-IBA21873635  
GO:0001821histamine secretion-IEA-  
GO:0002865negative regulation of acute inflammatory response to antigenic stimulus-IBA21873635  
GO:0002865negative regulation of acute inflammatory response to antigenic stimulus-IEA-  
GO:0002878negative regulation of acute inflammatory response to non-antigenic stimulus-IBA21873635  
GO:0002878negative regulation of acute inflammatory response to non-antigenic stimulus-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA9603988  
GO:0007190activation of adenylate cyclase activity-TAS1730060  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IDA23800469  
GO:0007267cell-cell signaling-TAS2302217  
GO:0007420brain development-IBA21873635  
GO:0007565female pregnancy-TAS10698193  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IBA21873635  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IDA11175907  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010656negative regulation of muscle cell apoptotic process-IBA21873635  
GO:0010656negative regulation of muscle cell apoptotic process-IEA-  
GO:0010976positive regulation of neuron projection development-IBA21873635  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0019233sensory perception of pain-IBA21873635  
GO:0019233sensory perception of pain-IEA-  
GO:0019933cAMP-mediated signaling-IMP23800469  
GO:0021983pituitary gland development-IBA21873635  
GO:0021983pituitary gland development-IEA-  
GO:0030073insulin secretion-IBA21873635  
GO:0030073insulin secretion-ISS-  
GO:0031175neuron projection development-IBA21873635  
GO:0031175neuron projection development-IDA23800469  
GO:0032755positive regulation of interleukin-6 production-IBA21873635  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0032880regulation of protein localization-IBA21873635  
GO:0032880regulation of protein localization-IDA9603988  
GO:0034260negative regulation of GTPase activity-IBA21873635  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0042594response to starvation-IBA21873635  
GO:0042594response to starvation-IEA-  
GO:0043010camera-type eye development-IBA21873635  
GO:0043267negative regulation of potassium ion transport-IBA21873635  
GO:0043267negative regulation of potassium ion transport-IEA-  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0043547positive regulation of GTPase activity-IDA23800469  
GO:0043950positive regulation of cAMP-mediated signaling-IBA21873635  
GO:0043950positive regulation of cAMP-mediated signaling-IEA-  
GO:0045471response to ethanol-IBA21873635  
GO:0045471response to ethanol-IEA-  
GO:0045786negative regulation of cell cycle-IBA21873635  
GO:0045786negative regulation of cell cycle-IEA-  
GO:0045860positive regulation of protein kinase activity-IBA21873635  
GO:0045860positive regulation of protein kinase activity-IDA23800469  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA23800469  
GO:0046034ATP metabolic process-IBA21873635  
GO:0046034ATP metabolic process-IEA-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0051968positive regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060078regulation of postsynaptic membrane potential-IBA21873635  
GO:0060078regulation of postsynaptic membrane potential-IEA-  
GO:0060124positive regulation of growth hormone secretion-IBA21873635  
GO:0060124positive regulation of growth hormone secretion-ISS-  
GO:0060253negative regulation of glial cell proliferation-IBA21873635  
GO:0060253negative regulation of glial cell proliferation-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA23800469  
GO:0070445regulation of oligodendrocyte progenitor proliferation-IBA21873635  
GO:0070445regulation of oligodendrocyte progenitor proliferation-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IBA21873635  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:0071651positive regulation of chemokine (C-C motif) ligand 5 production-IBA21873635  
GO:0071651positive regulation of chemokine (C-C motif) ligand 5 production-IDA24696163  
GO:0090274positive regulation of somatostatin secretion-IBA21873635  
GO:0090274positive regulation of somatostatin secretion-IEA-  
GO:0097755positive regulation of blood vessel diameter-IBA21873635  
GO:0097755positive regulation of blood vessel diameter-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IEA-  
GO:0005622intracellular-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043195terminal bouton-IBA21873635  
GO:0043195terminal bouton-IEA-  
GO:0043204perikaryon-IBA21873635  
GO:0070852cell body fiber-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-187015Activation of TRKA receptorsIEA
R-HSA-187024NGF-independant TRKA activationIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20554694Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)Kovanen LAlcohol Alcohol
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
28506824Hypoxia and nicotine effects on Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the developing piglet brainstem. (2017 Sep)Huang JNeurotoxicology
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum