Gene: SLC22A12

116085
OAT4L|RST|URAT1
solute carrier family 22 member 12
protein-coding
11q13.1
Ensembl:ENSG00000197891 MIM:607096 Vega:OTTHUMG00000045213 UniprotKB:Q96S37
NG_008110.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.381e-1 (AD)  6.970e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOP30.545
MUC170.528
FAM83C0.514
OR7C20.508
C8B0.501
OTOR0.497
TBATA0.485
PLA2G2E0.476
PTH20.474
ASMT0.47

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL13-0.236
C8orf37-0.221
ANKRD45-0.219
ZNF514-0.218
ASAP2-0.208
PRM1-0.204
TRIQK-0.201
DCHS2-0.196
ZNF33B-0.19
RAD21L1-0.188

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00678LosartanSmall Molecule114798-26-4ApprovedTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedTarget
DB11560LesinuradSmall Molecule878672-00-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0642974-hydroxystilbene4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C0859236-hydroxybenzbromarone6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
C0859236-hydroxybenzbromarone6-hydroxybenzbromarone results in decreased activity of SLC22A12 protein21449597
D020106AcrylamideAcrylamide results in decreased expression of SLC22A12 mRNA28959563
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]21909718|2286564
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
D010130p-Aminohippuric AcidBarium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D010130p-Aminohippuric AcidDiethyl Pyrocarbonate inhibits the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D010130p-Aminohippuric AcidOuabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D010130p-Aminohippuric AcidPotassium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D010130p-Aminohippuric AcidSLC22A12 protein results in increased uptake of p-Aminohippuric Acid15284287
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A12 mRNA16483693
D001151ArsenicArsenic affects the methylation of SLC22A12 gene25304211
D001464BariumBarium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
C004528benzaronebenzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D001553BenzbromaroneBenzbromarone affects the activity of SLC22A12 protein14694169
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]16135657
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D001553BenzbromaroneBenzbromarone results in decreased activity of SLC22A12 protein20486468|2144959
D001553BenzbromaroneSLC22A12 protein affects the susceptibility to Benzbromarone18670416
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SLC22A12 promoter]19654925
D004958EstradiolEstradiol results in decreased expression of SLC22A12 protein21360409
C006780bisphenol Abisphenol A results in decreased methylation of SLC22A12 promoter24433282
C006780bisphenol Abisphenol A results in decreased expression of SLC22A12 mRNA25181051
D002104CadmiumCadmium results in increased expression of SLC22A12 mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC22A12 mRNA17327699
D002712ChloridesChlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D002713Chlorine[Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D002713Chlorine[Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D002713Chlorine[Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D002713Chlorine[Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D002713ChlorineChlorine inhibits the reaction [SLC22A12 protein results in increased import of perfluorooctanoic acid]20639259
D002713ChlorineChlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D0150842,4-Dichlorophenoxyacetic Acid"Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]"15284287
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SLC22A12 mRNA23914054
D019314Dehydroepiandrosterone SulfatePotassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate]15284287
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC22A12 mRNA28962523
D004047Diethyl PyrocarbonateDiethyl Pyrocarbonate inhibits the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]"22967667
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]"22967667
C095803E 3040E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D004656EnalaprilEnalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D005363FicusinFicusin results in decreased expression of SLC22A12 protein22173200
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
D005632FructoseFructose results in increased expression of SLC22A12 mRNA19605544
D005632FructoseFructose results in increased expression of SLC22A12 protein19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
C030691gluconic acidgluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
C031534imperatorinimperatorin results in decreased expression of SLC22A12 mRNA22173200
C031534imperatorinimperatorin results in increased expression of SLC22A12 protein22173200
D007213IndomethacinIndomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
C055542isoimperatorinisoimperatorin results in decreased expression of SLC22A12 mRNA22173200
C055542isoimperatorinisoimperatorin results in increased expression of SLC22A12 protein22173200
D019344Lactic AcidLactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D019344Lactic AcidLactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D019808LosartanLosartan results in decreased activity of SLC22A12 protein20486468
D019808Losartan[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid18670416
D019808LosartanLosartan results in decreased expression of SLC22A12 mRNA20486468
D019808LosartanSLC22A12 protein affects the susceptibility to Losartan18670416
C013592mangiferinmangiferin results in decreased expression of SLC22A12 mRNA21348301
C013592mangiferinmangiferin results in decreased expression of SLC22A12 protein21348301
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC22A12 mRNA19465457
C030589methylmercury cysteinemethylmercury cysteine affects the expression of SLC22A12 mRNA19465457
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC22A12 mRNA"20188158
C420606mulberroside Amulberroside A inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C025589ochratoxin Aochratoxin A results in decreased expression of SLC22A12 mRNA18417182
D010117OxypurinolBenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]16135657
D010117OxypurinolSLC22A12 protein results in increased uptake of Oxypurinol16135657
D010117OxypurinolUric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]16135657
D010400Penicillin GPotassium promotes the reaction [SLC22A12 protein results in increased uptake of Penicillin G]15284287
C036567perfluorodecanoic acid[Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
C101815perfluoro-n-heptanoic acid[Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
C101816perfluoro-n-nonanoic acid[Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
C023036perfluorooctanoic acid[Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
C023036perfluorooctanoic acidChlorine inhibits the reaction [SLC22A12 protein results in increased import of perfluorooctanoic acid]20639259
C023036perfluorooctanoic acidSLC22A12 protein results in increased import of perfluorooctanoic acid20639259
D010634PhenobarbitalPhenobarbital affects the expression of SLC22A12 mRNA19136022
D010653PhenylbutazonePhenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
C006253pirinixic acidpirinixic acid affects the expression of SLC22A12 mRNA19136022
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]22967667
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22967667
C058229polydatinpolydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
D011188Potassium"Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]"15284287
D011188PotassiumPotassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate]15284287
D011188PotassiumPotassium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D011188PotassiumPotassium promotes the reaction [SLC22A12 protein results in increased uptake of Penicillin G]15284287
C489337potassium oxonate4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]21909718|2286564
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]"22967667
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]"22967667
C489337potassium oxonatemulberroside A inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]22967667
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22967667
C489337potassium oxonatepolydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C489337potassium oxonatepotassium oxonate results in increased expression of SLC22A12 mRNA21909718|2296766
C489337potassium oxonatepotassium oxonate results in increased expression of SLC22A12 protein21909718|2286564
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]22967667
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646|2296766
C489337potassium oxonatepterostilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]21909718
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]21909718
D011339ProbenecidProbenecid affects the activity of SLC22A12 protein14694169
D011339ProbenecidProbenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]22967667
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646|2296766
D011339ProbenecidProbenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC22A12 mRNA24780913
C107773pterostilbenepterostilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]22865646
D011718PyrazinamidePyrazinamide affects the activity of SLC22A12 protein14694169
C005296pyrazinoic acidpyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
C005296pyrazinoic acidpyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]21909718
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]21909718
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]19605544
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]19605544
D012459SalicylatesSalicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D010042OuabainOuabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]15284287
D013442SulfinpyrazoneSulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A12 mRNA26377647
D014527Uric Acid6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric Acidbenzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidBenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric Acid[Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D014527Uric Acid[Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D014527Uric Acid[Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D014527Uric Acid[Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D014527Uric AcidChlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]20639259
D014527Uric AcidE 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidEnalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidIndomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric Acid[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid18670416
D014527Uric AcidPhenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidProbenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidSalicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidSLC22A12 protein results in increased import of Uric Acid20639259
D014527Uric AcidSLC22A12 protein results in increased uptake of Uric Acid14694169|2127212
D014527Uric AcidSulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]21272127
D014527Uric AcidUric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]16135657
D014527Uric AcidBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D014527Uric Acidgluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D014527Uric AcidLactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D014527Uric AcidProbenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D014527Uric Acidpyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]14747372
D014527Uric AcidSLC22A12 protein affects the transport of Uric Acid14747372
D014527Uric AcidSLC22A12 protein results in increased export of Uric Acid15284287
D014527Uric AcidBenzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D014527Uric AcidChlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D014527Uric AcidLactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D014527Uric Acidpyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]21074513
D014527Uric AcidSLC22A12 protein affects the transport of Uric Acid21074513
D014635Valproic AcidValproic Acid results in increased methylation of SLC22A12 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SLC22A12 mRNA17292431
D014640VancomycinVancomycin results in increased expression of SLC22A12 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC22A12 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A12 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015143urate transmembrane transporter activity-IDA12024214  
GO:0015143urate transmembrane transporter activity-TAS-  
GO:0030165PDZ domain binding-IPI15304510  
GO ID GO Term Qualifier Evidence PubMed
GO:0015698inorganic anion transport-IEA-  
GO:0015747urate transport-IDA12024214  16775029  
GO:0019725cellular homeostasis-NAS15772301  
GO:0042493response to drug-IDA12024214  
GO:0046415urate metabolic process-IMP19503597  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA14694169  16775029  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA12024214  
GO:0016324apical plasma membrane-IDA12024214  
GO:0031526brush border membrane-ISS-  
GO:0031526brush border membrane-NAS12024214  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS
R-HSA-561048Organic anion transportTAS
R-HSA-5619071Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28575117Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. (2017)Miller MAPLoS One