Gene: NUS1

116150
C6orf68|CDG1AA|MGC:7199|MRD55|NgBR|TANGO14
NUS1, dehydrodolichyl diphosphate synthase subunit
protein-coding
6q22.1
Ensembl:ENSG00000153989 MIM:610463 Vega:OTTHUMG00000015458 UniprotKB:Q96E22
NG_054913.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.643e-1 (AD)  3.329e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM180.955
SHOC20.943
CGGBP10.942
YTHDF30.94
FBXO280.94
CNOT70.94
ATF20.938
BTF3L40.937
KPNA40.935
NAA300.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.602
OR4F29-0.552
CSAG1-0.327
VNN3-0.289
NXNL1-0.288
S100A1-0.288
ASB4-0.277
ANPEP-0.269
MYOM1-0.266
MTRNR2L10-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NUS1 mRNA"25614096
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NUS1 mRNA"18648102
C0138134-anisidine4-anisidine results in decreased expression of NUS1 mRNA12929121
D000082AcetaminophenAcetaminophen affects the expression of NUS1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of NUS1 mRNA19420014
C016601afimoxifeneafimoxifene results in decreased expression of NUS1 mRNA16514628
D001372Aza CompoundsAza Compounds results in decreased expression of NUS1 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of NUS1 mRNA20521778
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NUS1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NUS1 mRNA19770486|2222880
D004958EstradiolEstradiol results in increased expression of NUS1 mRNA16514628
C006780bisphenol Abisphenol A affects the expression of NUS1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NUS1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NUS1 mRNA27339419
C018021cobaltous chloridecobaltous chloride results in increased expression of NUS1 mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of NUS1 mRNA19770486
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of NUS1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NUS1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of NUS1 mRNA27594783
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NUS1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NUS1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of NUS1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NUS1 mRNA24136188
C070081fulvestrantfulvestrant results in decreased expression of NUS1 mRNA16514628
D005839GentamicinsGentamicins results in increased expression of NUS1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of NUS1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of NUS1 mRNA28973697
D006918HydroxyureaHydroxyurea results in decreased expression of NUS1 mRNA12929121
D007211IndolesIndoles results in decreased expression of NUS1 mRNA20521778
D007211IndolesIndoles results in increased expression of NUS1 mRNA20521778
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NUS1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of NUS1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NUS1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NUS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NUS1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of NUS1 mRNA24136188
C012655nimesulidenimesulide results in increased expression of NUS1 mRNA24136188
D017239PaclitaxelPaclitaxel results in decreased expression of NUS1 mRNA12929121
D010634PhenobarbitalPhenobarbital results in increased expression of NUS1 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of NUS1 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of NUS1 mRNA23370395
C045950propiconazolepropiconazole results in increased expression of NUS1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of NUS1 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of NUS1 mRNA16514628
D012999SomanSoman results in increased expression of NUS1 mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of NUS1 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of NUS1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUS1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NUS1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NUS1 mRNA23409001|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NUS1 mRNA28065790
D014635Valproic AcidValproic Acid results in decreased methylation of NUS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NUS1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of NUS1 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0004659prenyltransferase activitycontributes_toIDA25066056  
GO:0005515protein binding-IPI21572394  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0019408dolichol biosynthetic process-IMP25066056  
GO:0030154cell differentiation-IEA-  
GO:0032383regulation of intracellular cholesterol transport-IGI19723497  
GO:0035268protein mannosylation-IEA-  
GO:0038084vascular endothelial growth factor signaling pathway-IMP28602162  
GO:0042632cholesterol homeostasis-IEA-  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP28602162  
GO:0051000positive regulation of nitric-oxide synthase activity-IMP28602162  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IDA19723497  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:1904423dehydrodolichyl diphosphate synthase complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446199Synthesis of Dolichyl-phosphateTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29638194The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease. (2018 Apr 1)Ozkaramanli Gur DVasc Med