Gene: PHACTR3

116154
C20orf101|H17739|PPP1R123|SCAPIN1|SCAPININ
phosphatase and actin regulator 3
protein-coding
20q13.32-q13.33
Ensembl:ENSG00000087495 MIM:608725 Vega:OTTHUMG00000032869 UniprotKB:Q96KR7
NG_029537.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.752e-1 (AD)  7.982e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6070956chr20:59809755 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6027132chr20:59809396 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIRT20.884
ZBTB470.858
FEZ10.857
SEPT80.85
SEPT70.846
SAP180.846
FBXW40.846
CASC30.844
MAP40.843
MARCKSL10.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.763
OR4F5-0.71
MUC15-0.235
UPK1B-0.216
DMBX1-0.215
PIWIL3-0.214
DMP1-0.209
DSG2-0.205
SULT1E1-0.201
FER1L6-0.201

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR3 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of PHACTR3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PHACTR3 gene27153756
D001280AtrazineAtrazine results in decreased expression of PHACTR3 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of PHACTR3 mRNA22323515
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PHACTR3 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of PHACTR3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of PHACTR3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PHACTR3 mRNA22079614
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PHACTR3 mRNA20971185
D003976DiazinonDiazinon results in decreased methylation of PHACTR3 gene22964155
D005557FormaldehydeFormaldehyde results in decreased expression of PHACTR3 mRNA20655997
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PHACTR3 mRNA26752646
D007649KetamineKetamine results in decreased expression of PHACTR3 mRNA20080153
C045463leflunomideleflunomide results in increased expression of PHACTR3 mRNA28988120
D015122MercaptopurineMercaptopurine results in increased expression of PHACTR3 mRNA23358152
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PHACTR3 mRNA20971185
C558013NSC 689534NSC 689534 results in decreased expression of PHACTR3 mRNA20971185
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PHACTR3 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of PHACTR3 mRNA19690047
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PHACTR3 mRNA21427059
C017947sodium arsenitesodium arsenite affects the methylation of PHACTR3 gene28589171
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PHACTR3 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of PHACTR3 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PHACTR3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PHACTR3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PHACTR3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PHACTR3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of PHACTR3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PHACTR3 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0004864protein phosphatase inhibitor activity-IEA-  
GO:0008157protein phosphatase 1 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0016363nuclear matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal