Gene: GRIN3A

116443
GluN3A|NMDAR-L|NR3A
glutamate ionotropic receptor NMDA type subunit 3A
protein-coding
9q31.1
Ensembl:ENSG00000198785 MIM:606650 Vega:OTTHUMG00000020387 UniprotKB:Q8TCU5
NC_000009.12
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.970e-1 (AD)  7.209e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR40.922
ROBO20.921
EPHA50.919
SPHKAP0.908
KCNA60.892
NXPH20.889
RAB27B0.887
PGM2L10.887
MYO160.884
NBEA0.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.626
TGIF1-0.608
RNF135-0.605
AGTRAP-0.597
HEBP2-0.594
ROM1-0.593
HVCN1-0.589
HEY2-0.588
CHST14-0.588
GNG5-0.588

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalTarget
DB00333MethadoneSmall Molecule76-99-3ApprovedTarget
DB00392EthopropazineSmall Molecule522-00-9ApprovedTarget
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00915AmantadineSmall Molecule768-94-5ApprovedTarget
DB00949FelbamateSmall Molecule25451-15-4ApprovedTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01161ChloroprocaineSmall Molecule133-16-4ApprovedTarget
DB01173OrphenadrineSmall Molecule83-98-7ApprovedTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB01520TenocyclidineSmall Molecule21500-98-1Experimental|Illicit|InvestigationalTarget
DB01549RolicyclidineSmall Molecule2201-39-0Experimental|IllicitTarget
DB03575PhencyclidineSmall Molecule77-10-1IllicitTarget
DB04926NeramexaneSmall Molecule219810-59-0InvestigationalTarget
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTarget
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB06741GavestinelSmall Molecule153436-22-7InvestigationalTarget
DB09409Magnesium acetate tetrahydrateSmall Molecule16674-78-5ApprovedTarget
DB09481Magnesium carbonateSmall Molecule546-93-0Approved|InvestigationalTarget
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTarget
DB00289AtomoxetineSmall Molecule83015-26-3ApprovedTarget
DB00312PentobarbitalSmall Molecule76-74-4Approved|InvestigationalTarget
DB00418SecobarbitalSmall Molecule76-73-3ApprovedTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01174PhenobarbitalSmall Molecule50-06-6Approved|InvestigationalTarget
DB01708PrasteroneSmall Molecule53-43-0Approved|Investigational|NutraceuticalTarget
DB04896MilnacipranSmall Molecule92623-85-3Approved|InvestigationalTarget
DB06738KetobemidoneSmall Molecule469-79-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of GRIN3A mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIN3A mRNA"19114083
D020106AcrylamideAcrylamide affects the expression of GRIN3A mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of GRIN3A protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIN3A mRNA16483693
C015001arsenitearsenite results in increased methylation of GRIN3A promoter23974009
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN3A mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of GRIN3A mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of GRIN3A mRNA22079614
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN3A mRNA25607892
D000068579CelecoxibCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]21589914
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRIN3A mRNA19440498
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRIN3A mRNA17452286|1944049
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIN3A gene20938992
D015283CitalopramGRIN3A polymorphism affects the susceptibility to Citalopram19295509
D003042CocaineCocaine affects the expression of GRIN3A protein15140200
D003300CopperCopper deficiency results in increased expression of GRIN3A mRNA26033743
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GRIN3A mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of GRIN3A mRNA26033743
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN3A mRNA25607892
D000431EthanolEthanol results in decreased expression of GRIN3A mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRIN3A mRNA29097150
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in decreased expression of GRIN3A protein17550430
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIN3A gene20938992
D007608Kainic AcidCelecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]21589914
D007608Kainic AcidKainic Acid results in decreased expression of GRIN3A mRNA21589914
D007608Kainic AcidPTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]21589914
C008261lead acetatelead acetate results in increased expression of GRIN3A mRNA24260418
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GRIN3A gene20938992
D008727MethotrexateMethotrexate results in increased expression of GRIN3A mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRIN3A mRNA"20188158
D009532NickelNickel results in decreased expression of GRIN3A mRNA24768652
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN3A mRNA25607892
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GRIN3A mRNA26705709
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GRIN3A mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of GRIN3A mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GRIN3A mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of GRIN3A mRNA29319823
C009495titanium dioxidetitanium dioxide results in decreased expression of GRIN3A mRNA23409001
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GRIN3A mRNA19042947
C111237vorinostatvorinostat results in decreased expression of GRIN3A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004972NMDA glutamate receptor activity-IDA17502428  
GO:0004972NMDA glutamate receptor activitycontributes_toISS-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0005262calcium channel activity-IEA-  
GO:0005515protein binding-IPI17658481  17997397  
GO:0016594glycine binding-IDA17320117  
GO:0042802identical protein binding-IPI17997397  
GO:0051721protein phosphatase 2A binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-ISS-  
GO:0016358dendrite development-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0045471response to ethanol-IDA17502428  18445116  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060134prepulse inhibition-IEA-  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-IDA17997397  
GO:0016021integral component of membrane-NAS11880201  
GO:0017146NMDA selective glutamate receptor complex-IDA17997397  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IDA17658481  
GO:0043025neuronal cell body-IDA17658481  
GO:0045202synapse-IDA17658481  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20084518Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. (2010 Mar)Ma JZHum Genet
20813242Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. (2010)Bjork KInt Rev Neurobiol