Gene info: ID 116444

Gene: GRIN3B

GENE ID: 116444

Synonyms: GluN3B|NR3B

Description: glutamate ionotropic receptor NMDA type subunit 3B

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000116032 MIM:606651 Vega:OTTHUMG00000181904 UniprotKB:O60391

RefSeq: NC_000019.10

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.497e-1 (AD) 5.664e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4807395	chr19:1002848 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLEKHG4	0.629
UVSSA	0.596
MSH5	0.566
FCHSD1	0.564
RHBDF1	0.56
MYO15B	0.551
NEK8	0.534
MBD6	0.531
POFUT2	0.528
ARHGEF1	0.528

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MUC12	-0.205
PPIAL4D	-0.193
GRHL2	-0.19
IQCJ	-0.188
NANOS3	-0.188
HNF1A	-0.184
EGFL6	-0.184
SMIM18	-0.182
CBLN1	-0.18
CCDC73	-0.177

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00145	Glycine	Small Molecule	56-40-6	Approved\|Nutraceutical	Target
DB01159	Halothane	Small Molecule	151-67-7	Approved	Target
DB01173	Orphenadrine	Small Molecule	83-98-7	Approved	Target
DB01520	Tenocyclidine	Small Molecule	21500-98-1	Experimental\|Illicit\|Investigational	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB06741	Gavestinel	Small Molecule	153436-22-7	Investigational	Target
DB09409	Magnesium acetate tetrahydrate	Small Molecule	16674-78-5	Approved	Target
DB09481	Magnesium carbonate	Small Molecule	546-93-0	Approved\|Investigational	Target
DB13146	Fluciclovine (18F)	Small Molecule	222727-39-1	Approved	Target
DB00289	Atomoxetine	Small Molecule	83015-26-3	Approved	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00418	Secobarbital	Small Molecule	76-73-3	Approved	Target
DB00996	Gabapentin	Small Molecule	60142-96-3	Approved\|Investigational	Target
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB04896	Milnacipran	Small Molecule	92623-85-3	Approved\|Investigational	Target
DB06738	Ketobemidone	Small Molecule	469-79-4	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of GRIN3B mRNA"	19114083
D000082	Acetaminophen	Acetaminophen affects the expression of GRIN3B mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRIN3B mRNA	16483693
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to GRIN3B promoter]	19654925
D004958	Estradiol	Estradiol affects the expression of GRIN3B mRNA	22574217
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN3B mRNA	25270620
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN3B mRNA	25181051
C584509	C646 compound	C646 compound results in increased expression of GRIN3B mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of GRIN3B promoter	22457795
D000068579	Celecoxib	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]	21589914
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GRIN3B mRNA	19440498
D003042	Cocaine	Cocaine affects the expression of GRIN3B protein	15140200
D003471	Cuprizone	Cuprizone results in decreased expression of GRIN3B mRNA	26577399
D003907	Dexamethasone	Dexamethasone results in decreased expression of GRIN3B mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRIN3B mRNA]	20032058
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GRIN3B mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GRIN3B mRNA	27392435
D004026	Dieldrin	Dieldrin affects the expression of GRIN3B mRNA	19440498
D000431	Ethanol	Ethanol results in decreased expression of GRIN3B mRNA	20655511
D006220	Haloperidol	Haloperidol results in increased expression of GRIN3B mRNA	15860345
C492448	ICG 001	ICG 001 results in increased expression of GRIN3B mRNA	26191083
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GRIN3B mRNA	27392435
D007608	Kainic Acid	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]	21589914
D007608	Kainic Acid	Kainic Acid results in decreased expression of GRIN3B mRNA	21589914
C008261	lead acetate	lead acetate results in increased expression of GRIN3B mRNA	24260418
C008261	lead acetate	lead acetate results in increased expression of GRIN3B mRNA	22160880
D008727	Methotrexate	GRIN3B protein affects the susceptibility to Methotrexate	16217747
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of GRIN3B mRNA	22401849
D009532	Nickel	Nickel results in increased expression of GRIN3B mRNA	19440498
D010100	Oxygen	Oxygen deficiency results in increased expression of GRIN3B mRNA	26516004
C005556	propionaldehyde	propionaldehyde results in increased expression of GRIN3B mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GRIN3B mRNA	24780913
D013629	Tamoxifen	Tamoxifen results in decreased expression of GRIN3B mRNA	25123088
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRIN3B mRNA]	20032058
D014635	Valproic Acid	Valproic Acid results in increased methylation of GRIN3B gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004970	ionotropic glutamate receptor activity	-	IEA	-
GO:0005234	extracellularly glutamate-gated ion channel activity	-	IEA	-
GO:0005261	cation channel activity	-	ISS	-
GO:0005262	calcium channel activity	contributes_to	ISS	11735224
GO:0016594	glycine binding	-	ISS	-
GO:0030594	neurotransmitter receptor activity	-	ISS	-
GO:0042165	neurotransmitter binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0035235	ionotropic glutamate receptor signaling pathway	-	ISS	-
GO:0051205	protein insertion into membrane	-	ISS	11735224
GO:0051924	regulation of calcium ion transport	-	ISS	11735224
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0070588	calcium ion transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IBA	21873635
GO:0017146	NMDA selective glutamate receptor complex	-	ISS	11735224
GO:0017146	NMDA selective glutamate receptor complex	-	NAS	11735224
GO:0030054	cell junction	-	IEA	-
GO:0043025	neuronal cell body	-	ISS	11735224
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal