Gene: TOP1MT

116447
-
DNA topoisomerase I mitochondrial
protein-coding
8q24.3
Ensembl:ENSG00000184428 MIM:606387 Vega:OTTHUMG00000164979 UniprotKB:Q969P6
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.781e-1 (AD)  5.049e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08597832chr8:144416327TOP1MT6.120e-11Alcohol consumption der day27843151
cg12188860chr8:144416485TOP1MT6.170e-9Alcohol consumption der day27843151
cg23629150chr8:144416404TOP1MT1.670e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SURF60.736
FLII0.734
STX40.733
PRMT20.733
RILPL10.733
CYTH10.729
SAFB0.728
HDLBP0.728
PWP20.727
PAF10.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.47
OR4F5-0.469
MTRNR2L9-0.356
MTRNR2L10-0.35
MTRNR2L6-0.33
ANKRD18B-0.327
TTLL10-0.295
P2RY14-0.288
OR4F16-0.279
MTRNR2L2-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TOP1MT mRNA"21346803
D000638AmiodaroneAmiodarone results in increased expression of TOP1MT mRNA24489787
D001280AtrazineAtrazine results in increased expression of TOP1MT mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TOP1MT mRNA22228805
C006780bisphenol Abisphenol A affects the expression of TOP1MT mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TOP1MT mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of TOP1MT gene22576693
C006780bisphenol Abisphenol A results in increased expression of TOP1MT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TOP1MT gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TOP1MT mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of TOP1MT mRNA25979313
D000068579CelecoxibCelecoxib results in decreased expression of TOP1MT mRNA28201806
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TOP1MT mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TOP1MT mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of TOP1MT mRNA18042831
D018120FinasterideFinasteride results in increased expression of TOP1MT mRNA24136188
C039281furanfuran results in increased methylation of TOP1MT gene22079235
D005897GlafenineGlafenine results in decreased expression of TOP1MT mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TOP1MT mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TOP1MT mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TOP1MT mRNA27392435
C544151jinfukangjinfukang results in increased expression of TOP1MT mRNA27392435
D000073878Palm OilPalm Oil results in decreased expression of TOP1MT mRNA18042831
D018038Sodium SeleniteSodium Selenite results in increased expression of TOP1MT mRNA18175754
D012999SomanSoman results in decreased expression of TOP1MT mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of TOP1MT mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOP1MT mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of TOP1MT mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of TOP1MT mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of TOP1MT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TOP1MT mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of TOP1MT gene29154799
C025643vinclozolinvinclozolin results in increased expression of TOP1MT mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003917DNA topoisomerase type I activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-IBA21873635  
GO:0006265DNA topological change-IBA21873635  
GO:0006338chromatin remodeling-IBA21873635  
GO:0007059chromosome segregation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0031298replication fork protection complex-IBA21873635  
GO:0042645mitochondrial nucleoid-IBA21873635  
GO:0042645mitochondrial nucleoid-IDA18063578  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355294Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter. (2017)Hou GXPLoS One