Gene: LRG1

116844
HMFT1766|LRG
leucine rich alpha-2-glycoprotein 1
protein-coding
19p13.3
Ensembl:ENSG00000171236 MIM:611289 Vega:OTTHUMG00000182010 UniprotKB:P02750
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.549e-1 (AD)  4.194e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD930.863
PDLIM10.813
CASP40.812
ADAMTS90.802
PSTPIP20.79
GPR840.786
RAC20.784
CSF2RB0.784
FPR20.779
KIAA00400.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.487
EXTL1-0.469
KIT-0.461
VWC2-0.46
KCNIP3-0.459
TMEM179-0.459
MARCH4-0.458
GAD2-0.457
SLC32A1-0.455
F7-0.454

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of LRG1 mRNA"28903501
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of LRG1 mRNA28522335
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in decreased expression of LRG1 mRNA25716159
C496492abrineabrine results in increased expression of LRG1 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of LRG1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of LRG1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRG1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRG1 mRNA19770486
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LRG1 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LRG1 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of LRG1 mRNA"23917077
D001280AtrazineAtrazine results in increased expression of LRG1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRG1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRG1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRG1 mRNA21839799
D004958EstradiolEstradiol affects the expression of LRG1 mRNA15598610
D004958EstradiolEstradiol results in increased expression of LRG1 mRNA15289156|1948475
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of LRG1 mRNA17630414
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LRG1 promoter23359474
C006780bisphenol Abisphenol A results in increased expression of LRG1 mRNA25181051
D002104CadmiumLRG1 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LRG1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LRG1 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LRG1 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of LRG1 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of LRG1 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRG1 gene20938992
D002994ClofibrateClofibrate results in decreased expression of LRG1 mRNA17585979
D003300CopperLRG1 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of LRG1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of LRG1 mRNA20106945|2556210
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
C017180decamethrindecamethrin results in increased expression of LRG1 mRNA19017407
D016264Dextran SulfateDextran Sulfate results in increased expression of LRG1 mRNA23894361
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LRG1 promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of LRG1 mRNA28962523
D002945CisplatinCisplatin results in increased expression of LRG1 mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of LRG1 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of LRG1 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of LRG1 mRNA18042831
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LRG1 promoter23359474
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LRG1 mRNA15289156
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRG1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRG1 mRNA17942748
D005473FluoxetineFluoxetine results in increased expression of LRG1 mRNA17033635
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRG1 gene20938992
C546771gardiquimodgardiquimod results in increased expression of LRG1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LRG1 mRNA]28003376
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
D019833GenisteinGenistein results in decreased expression of LRG1 mRNA21048042
D019833GenisteinGenistein results in increased expression of LRG1 mRNA15289156
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
D005897GlafenineGlafenine results in increased expression of LRG1 mRNA24136188
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA27424125
D007545IsoproterenolIsoproterenol results in increased expression of LRG1 mRNA20003209
C410337K 7174K 7174 results in decreased expression of LRG1 mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LRG1 mRNA25890327|2733941
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRG1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRG1 mRNA23103053
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LRG1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LRG1 mRNA"25554681|2562005
C031721naphthalenenaphthalene results in increased expression of LRG1 mRNA18978301
D019829NevirapineNevirapine metabolite results in increased expression of LRG1 mRNA23947594
D009532NickelLRG1 protein binds to Nickel23896426
D009532NickelNickel results in increased expression of LRG1 mRNA12540486
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LRG1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LRG1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LRG1 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in decreased expression of LRG1 mRNA25658374
D010126OzoneOzone results in increased expression of LRG1 mRNA12763052
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of LRG1 mRNA]19555225
D000073878Palm OilPalm Oil results in decreased expression of LRG1 mRNA18042831
C016030pantogabpantogab results in increased expression of LRG1 mRNA17379144
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of LRG1 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LRG1 mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of LRG1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of LRG1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of LRG1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of LRG1 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of LRG1 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of LRG1 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of LRG1 mRNA19690047
D015742PropofolPropofol results in increased expression of LRG1 mRNA21786383
D011441PropylthiouracilPropylthiouracil results in decreased expression of LRG1 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LRG1 mRNA]28003376
D011794QuercetinQuercetin results in decreased expression of LRG1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LRG1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of LRG1 mRNA23221170
C017947sodium arsenitesodium arsenite affects the expression of LRG1 mRNA17450228
C016104sodium bichromatesodium bichromate results in increased expression of LRG1 mRNA27859739
D012969Sodium FluorideSodium Fluoride results in increased expression of LRG1 protein28918527
D012999SomanSoman results in increased expression of LRG1 mRNA19281266
C016766sulforafansulforafan results in increased expression of LRG1 mRNA26833863
C013698tallowtallow affects the expression of LRG1 mRNA19680557
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of LRG1 mRNA17630414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRG1 mRNA21632981
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRG1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRG1 mRNA19770486
C009495titanium dioxidetitanium dioxide affects the expression of LRG1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of LRG1 mRNA23409001|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LRG1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LRG1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of LRG1 mRNA23830798
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LRG1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of LRG1 mRNA17982090
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LRG1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of LRG1 mRNA29154799
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LRG1 mRNA27935865
C088658zoledronic acidzoledronic acid results in increased expression of LRG1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005160transforming growth factor beta receptor binding-IEA-  
GO:0005515protein binding-IPI23868260  
GO ID GO Term Qualifier Evidence PubMed
GO:0001938positive regulation of endothelial cell proliferation-IEA-  
GO:0008150biological_process-ND-  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0050873brown fat cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS12223515  14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA20363744  
GO:0016020membrane-NAS3856868  
GO:0035580specific granule lumen-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA23533145  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28434814Novel protein biomarkers associated with coronary artery disease in statin-treated patients with familial hypercholesterolemia. (2017 May - Jun)Bos SJ Clin Lipidol