Gene: AGAP1

116987
AGAP-1|CENTG2|GGAP1|cnt-g2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
protein-coding
2q37.2
Ensembl:ENSG00000157985 MIM:608651 Vega:OTTHUMG00000133293 UniprotKB:Q9UPQ3
NG_030314.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.791e-1 (AD)  8.054e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11688841chr2:235887157 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04048740chr2:236442999AGAP1Gene body6.869e-4Alcohol use disorders26763658
cg05779786chr2:237028849AGAP15.670e-9Maternal smoking in pregnancy27040690
cg03451670chr2:236579469AGAP17.500e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SBF10.905
KLF130.886
PPP1R16B0.877
TPPP0.876
TULP40.863
ZBTB40.862
RALBP10.859
ZC3H7B0.852
CDC42BPB0.851
B3GAT10.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.6
OR4F5-0.591
PDZK1IP1-0.395
PRRX2-0.354
AHSP-0.347
GAST-0.337
EGFLAM-0.321
HORMAD2-0.318
S100A14-0.316
TSLP-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AGAP1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AGAP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AGAP1 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AGAP1 mRNA24449571
D001151ArsenicArsenic affects the methylation of AGAP1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGAP1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGAP1 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGAP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGAP1 mRNA"19150397|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of AGAP1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of AGAP1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of AGAP1 mRNA25181051|2909715
C006780bisphenol Abisphenol A results in increased methylation of AGAP1 gene28505145
C054133casticincasticin results in decreased expression of AGAP1 mRNA28444820
D002922CiguatoxinsCiguatoxins affects the expression of AGAP1 mRNA18353800
D003375CoumestrolCoumestrol results in decreased expression of AGAP1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of AGAP1 mRNA27989131
C014347decitabinedecitabine affects the expression of AGAP1 mRNA23300844
D002945CisplatinCisplatin affects the expression of AGAP1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of AGAP1 mRNA22023808
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGAP1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AGAP1 mRNA23550701
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of AGAP1 mRNA27776689
D004397FonofosFonofos results in decreased methylation of AGAP1 promoter22847954
C069837fullerene C60fullerene C60 results in increased expression of AGAP1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of AGAP1 mRNA22061828
D007854LeadLead affects the expression of AGAP1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of AGAP1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of AGAP1 mRNA26378955
C030272maleic acidmaleic acid results in increased expression of AGAP1 mRNA28392987
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AGAP1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AGAP1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AGAP1 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AGAP1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AGAP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AGAP1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of AGAP1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of AGAP1 mRNA25729387
D010278ParathionParathion results in decreased methylation of AGAP1 promoter22847954
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGAP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AGAP1 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of AGAP1 mRNA21278054
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of AGAP1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of AGAP1 mRNA26378955
C012568terbufosterbufos results in decreased methylation of AGAP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGAP1 mRNA21570461
C009495titanium dioxidetitanium dioxide affects the expression of AGAP1 mRNA17656681
C009495titanium dioxidetitanium dioxide analog results in increased expression of AGAP1 mRNA25111187
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of AGAP1 mRNA25729387
D014415TunicamycinTunicamycin results in decreased expression of AGAP1 mRNA22378314
D014520UrethaneUrethane results in increased expression of AGAP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AGAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AGAP1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of AGAP1 gene29154799
C025643vinclozolinvinclozolin affects the expression of AGAP1 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of AGAP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005096GTPase activator activity-IEA-  
GO:0005525GTP binding-IEA-  
GO:0005543phospholipid binding-IDA18954304  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal