Gene info: ID 117159

Gene: DCD

GENE ID: 117159

Synonyms: AIDD|DCD-1|DSEP|HCAP|PIF

Description: dermcidin

Gene type: protein-coding

Location: 12q13.2

dbXrefs: Ensembl:ENSG00000161634 MIM:606634 Vega:OTTHUMG00000169937 UniprotKB:P81605

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.831e-1 (AD) 9.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KRT2	0.701
KRT1	0.649
KRT14	0.626
SCGB2A2	0.555
C1orf68	0.553
MB	0.552
SERPINA12	0.551
CKM	0.544
ACTA1	0.527
CALML5	0.522

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HIST1H4J	-0.24
GSX2	-0.203
CCDC54	-0.199
GP5	-0.198
CRABP1	-0.195
VSX2	-0.192
DOK7	-0.187
PCDHB11	-0.186
CYP4A11	-0.184
SLC7A3	-0.182

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of DCD protein"	25670856
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]	17532611
D001241	Aspirin	Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of DCD protein]	17303692
D001241	Aspirin	Aspirin results in decreased secretion of DCD protein	17303692
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]	17532611
D002104	Cadmium	Cadmium results in decreased expression of DCD mRNA	24376830
D002104	Cadmium	DCD protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of DCD mRNA	23828170
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DCD mRNA	16239168
C067513	CV 6504	CV 6504 inhibits the reaction [DCD protein results in increased expression of PSMA2 mRNA]	15451026
C067513	CV 6504	CV 6504 inhibits the reaction [DCD protein results in increased expression of PSMB5 mRNA]	15451026
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid inhibits the reaction [DCD protein results in increased expression of PSMA2 mRNA]	15451026
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid inhibits the reaction [DCD protein results in increased expression of PSMB5 mRNA]	15451026
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DCD protein	23301498
D007854	Lead	DCD protein binds to Lead	23896426
D009532	Nickel	Nickel results in decreased expression of DCD mRNA	24768652\|2558310
C119536	nickel acetate	nickel acetate affects the expression of DCD mRNA	23828170
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of DCD protein	19716841
D010936	Plant Extracts	Plant Extracts results in decreased expression of DCD mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of DCD protein	23718831
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of DCD protein]	17303692
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of DCD protein	17303692
D015032	Zinc	DCD protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0005515	protein binding	-	IPI	25416956
GO:0008233	peptidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IEA	-
GO:0019730	antimicrobial humoral response	-	TAS	-
GO:0031640	killing of cells of other organism	-	IEA	-
GO:0042742	defense response to bacterium	-	IEA	-
GO:0050832	defense response to fungus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IBA	21873635
GO:0005576	extracellular region	-	IDA	9736629
GO:0005576	extracellular region	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6803157	Antimicrobial peptides	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27707662	Dietary predictors of urinary cadmium among pregnant women and children. (2017 Jan 1)	Moynihan M	Sci Total Environ
26015077	Urinary cadmium and estimated dietary cadmium in the Women's Health Initiative. (2016 May-Jun)	Quraishi SM	J Expo Sci Environ Epidemiol