Gene: AP2M1

1173
AP50|CLAPM1|mu2
adaptor related protein complex 2 subunit mu 1
protein-coding
3q27.1
Ensembl:ENSG00000161203 MIM:601024 Vega:OTTHUMG00000156822 UniprotKB:Q96CW1
NC_000003.12
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.155e-1 (AD)  4.736e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13262chr3:184183601 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05573306chr3:183894763AP2M1Promoter7.019e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDH20.98
OTUB10.98
ATP6V1E10.978
UCHL10.977
SAE10.975
PPP1R110.975
DCTN20.975
GOT20.975
USP50.974
RNF1870.973

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.755
OR4F29-0.721
KCNJ15-0.346
CXCR2-0.341
MTRNR2L6-0.337
TFPI2-0.335
IL18RAP-0.335
REST-0.332
CSAG1-0.332
MTRNR2L10-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of AP2M1 mRNA12958071
C4988264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide[arsenic trioxide co-treated with 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide] affects the expression of AP2M1 mRNA28786057
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AP2M1 gene27153756
D000638AmiodaroneAmiodarone affects the expression of AP2M1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AP2M1 mRNA16483693
C006632arsenic trioxide[arsenic trioxide co-treated with 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide] affects the expression of AP2M1 mRNA28786057
D001280AtrazineAtrazine results in increased expression of AP2M1 mRNA22378314
D001553BenzbromaroneBenzbromarone affects the expression of AP2M1 mRNA19483382
C006780bisphenol Abisphenol A affects the expression of AP2M1 mRNA25181051
C099555CD 437CD 437 results in decreased expression of AP2M1 mRNA12958071
D002994ClofibrateClofibrate affects the expression of AP2M1 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of AP2M1 mRNA19376846
D003042CocaineCocaine results in increased expression of AP2M1 protein25100957
D016572CyclosporineCyclosporine results in decreased expression of AP2M1 mRNA25562108|2798913
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP2M1 mRNA17942748
D005001EthionineEthionine affects the expression of AP2M1 mRNA19483382
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of AP2M1 gene27776689
D005485FlutamideFlutamide results in decreased expression of AP2M1 mRNA24793618
D005978GlutathioneGlutathione deficiency results in increased expression of AP2M1 mRNA15345336
D007657Ketone BodiesKetone Bodies results in increased expression of AP2M1 mRNA16807920
D007854LeadLead results in decreased expression of AP2M1 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of AP2M1 mRNA21891863
D008731MethoxychlorMethoxychlor results in increased methylation of AP2M1 gene23303685
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AP2M1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of AP2M1 protein26558463
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein]17220478
C523184mocetinostatmocetinostat results in decreased expression of AP2M1 mRNA27255383
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AP2M1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AP2M1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of AP2M1 mRNA24136188
D005996NitroglycerinNitroglycerin results in increased expression of AP2M1 mRNA12102619
D009853OmeprazoleOmeprazole affects the expression of AP2M1 mRNA19483382
D010634PhenobarbitalPhenobarbital affects the expression of AP2M1 mRNA19159669
C014153pirimiphos methylpirimiphos methyl results in decreased expression of AP2M1 mRNA27845199
C006253pirinixic acidpirinixic acid affects the expression of AP2M1 mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of AP2M1 mRNA19483382
D012524SarinSarin results in increased expression of AP2M1 protein25842371
D012643SeleniumSelenium results in increased expression of AP2M1 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of AP2M1 mRNA20308225
D013629TamoxifenTamoxifen results in increased expression of AP2M1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AP2M1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AP2M1 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of AP2M1 protein24648495
D013853ThioacetamideThioacetamide affects the expression of AP2M1 mRNA19483382
D014050TolueneToluene affects the expression of AP2M1 mRNA21827849
D014118Toxins, Biological"Toxins, Biological affects the expression of AP2M1 mRNA"19682533
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of AP2M1 mRNA18422935
C406224valdecoxibvaldecoxib results in increased expression of AP2M1 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of AP2M1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of AP2M1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AP2M1 gene25560391
D014810Vitamin EVitamin E results in increased expression of AP2M1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005048signal sequence binding-IDA8918456  9171339  
GO:0005215transporter activity-TAS7989329  8595912  
GO:0005515protein binding-IPI10910768  12032142  16189514  19419997  20029029  22916011  
24189400  24603492  25107275  
GO:0008289lipid binding-IEA-  
GO:0035615clathrin adaptor activitycontributes_toTAS12121421  
GO:0044325ion channel binding-IPI23529131  
GO:0050750low-density lipoprotein particle receptor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0016050vesicle organization-IMP25898166  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0031623receptor internalization-IMP25898166  
GO:0032802low-density lipoprotein particle receptor catabolic process-TAS-  
GO:0034383low-density lipoprotein particle clearance-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0061024membrane organization-TAS-  
GO:0072583clathrin-dependent endocytosis-TAS12121421  
GO:0097494regulation of vesicle size-IMP25898166  
GO:1903077negative regulation of protein localization to plasma membrane-IMP19581412  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0030122AP-2 adaptor complex-TAS12121421  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0036020endolysosome membrane-TAS-  
GO:0045334clathrin-coated endocytic vesicle-NAS25898166  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersTAS
R-HSA-164939Nef mediated downregulation of CD28 cell surface expressionTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167590Nef Mediated CD4 Down-regulationTAS
R-HSA-168256Immune SystemTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-177504Retrograde neurotrophin signallingIEA
R-HSA-177504Retrograde neurotrophin signallingTAS
R-HSA-182218Nef Mediated CD8 Down-regulationTAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-190828Gap junction traffickingTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5140745WNT5A-dependent internalization of FZD2, FZD5 and ROR2TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8866427VLDLR internalisation and degradationTAS
R-HSA-8964038LDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal