Gene: RLN3

117579
H3|RXN3|ZINS4|insl7
relaxin 3
protein-coding
19p13.12
Ensembl:ENSG00000171136 MIM:606855 Vega:OTTHUMG00000181986 UniprotKB:Q8WXF3
NC_000019.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.882e-2 (AD)  5.566e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7249702chr19:14027400 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7247578chr19:14027335 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM400.567
DUXA0.529
C18orf630.525
FGF190.52
OR7C20.516
CNGA20.512
ODF40.51
TAAR10.509
MUC170.508
SPO110.507

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HYKK-0.228
GPR17-0.227
OTC-0.226
TOMM20L-0.219
CHRFAM7A-0.209
MDH1B-0.198
HIST1H4K-0.195
IQCA1-0.188
PDZD2-0.182
DSC1-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RLN3 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of RLN3 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of RLN3 mRNA25181051
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RLN3 mRNA23914054
D004041Dietary FatsDietary Fats results in increased expression of RLN3 mRNA25016146
C039281furanfuran results in decreased expression of RLN3 mRNA25539665
D007545IsoproterenolIsoproterenol results in increased expression of RLN3 mRNA16112403
D007545IsoproterenolIsoproterenol results in increased expression of RLN3 protein16112403
D010936Plant ExtractsPlant Extracts results in decreased expression of RLN3 mRNA23557933
D013853ThioacetamideThioacetamide results in increased methylation of RLN3 promoter27914986

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0005515protein binding-IPI24802387  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-444821Relaxin receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal