Gene: TWIST2

117581
AMS|BBRSAY|DERMO1|FFDD3|SETLSS|bHLHa39
twist family bHLH transcription factor 2
protein-coding
2q37.3
Ensembl:ENSG00000233608 MIM:607556 Vega:OTTHUMG00000152836 UniprotKB:Q8WVJ9
NG_032754.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.471e-1 (AD)  6.192e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR260.691
SSTR10.679
HS6ST30.653
C9orf1290.645
TMEM200A0.639
SLIT10.639
FAM78B0.633
C8orf340.633
OTUB20.632
GALNTL60.631

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTUD7B-0.489
STON2-0.471
NFIA-0.465
CYP2J2-0.455
ARHGAP19-0.453
C1orf198-0.451
ZHX2-0.442
MTMR10-0.44
C19orf18-0.439
CPM-0.437

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of TWIST2 mRNA"20638727
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TWIST2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TWIST2 mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TWIST2 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of TWIST2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TWIST2 mRNA23656968
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TWIST2 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of TWIST2 mRNA25210133
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TWIST2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of TWIST2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TWIST2 mRNA12075121
C006780bisphenol Abisphenol A results in increased methylation of TWIST2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TWIST2 mRNA28628672
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TWIST2 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TWIST2 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TWIST2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TWIST2 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of TWIST2 mRNA18579281
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TWIST2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TWIST2 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of TWIST2 mRNA19561079
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TWIST2 mRNA26924002
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of TWIST2 mRNA17490981
D004041Dietary FatsDietary Fats results in decreased expression of TWIST2 mRNA25016146
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of TWIST2 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TWIST2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TWIST2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TWIST2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TWIST2 mRNA12075121|1735126
D005419FlavonoidsFlavonoids results in decreased expression of TWIST2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TWIST2 gene20938992
C039281furanfuran results in increased methylation of TWIST2 gene22079235
D019833GenisteinGenistein results in increased expression of TWIST2 mRNA12075121
C577920GSK126GSK126 results in decreased expression of TWIST2 mRNA26424790
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TWIST2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TWIST2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TWIST2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TWIST2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of TWIST2 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TWIST2 mRNA12057914
C042720mercuric bromidemercuric bromide results in decreased expression of TWIST2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TWIST2 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TWIST2 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TWIST2 mRNA26924002
C000621033napabucasinnapabucasin results in decreased expression of TWIST2 mRNA25605917
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TWIST2 mRNA27935865
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TWIST2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TWIST2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of TWIST2 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of TWIST2 mRNA]20059764
C059514resveratrolresveratrol results in decreased expression of TWIST2 protein25505154
D012906SmokeSmoke results in increased expression of TWIST2 mRNA21095227
D013629TamoxifenTamoxifen affects the expression of TWIST2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TWIST2 mRNA21998131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TWIST2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TWIST2 mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of TWIST2 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TWIST2 mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of TWIST2 mRNA28001369
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TWIST2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI18598946  25416956  25814554  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045668negative regulation of osteoblast differentiation-IDA11062344  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11062344  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA11062344  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26081431Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. (2015 Jun 18)Nishioka MRespir Res