Gene: CLCA1

1179
CACC|CACC1|CLCRG1|CaCC-1|GOB5|hCLCA1|hCaCC-1
chloride channel accessory 1
protein-coding
1p22.3
Ensembl:ENSG00000016490 MIM:603906 Vega:OTTHUMG00000010254 UniprotKB:A8K7I4
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.232e-1 (AD)  4.325e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR51A40.578
OR5M90.523
OR6C60.509
TRIM64C0.507
OR4L10.506
OR51G10.505
KRT200.5
REG40.491
DEFB1100.488
RETNLB0.488

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM86B1-0.363
TENM2-0.358
ADRA1B-0.338
CDS1-0.331
MARCH4-0.331
SLITRK5-0.33
RAB36-0.33
DAPK1-0.328
CYP46A1-0.327
ST6GALNAC5-0.327

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CLCA1 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CLCA1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CLCA1 mRNA"25614096
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of CLCA1 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLCA1 mRNA19770486
D047310ApigeninApigenin results in decreased expression of CLCA1 mRNA22359648
D001151ArsenicArsenic results in decreased expression of CLCA1 mRNA19654921
D001151ArsenicArsenic results in increased expression of CLCA1 mRNA23221970
D001151ArsenicArsenic results in increased expression of CLCA1 protein22552367|2322197
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of CLCA1 mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLCA1 mRNA22228805
C075388beta-damascenonebeta-damascenone results in increased expression of CLCA1 mRNA22982537
D004958EstradiolEstradiol affects the expression of CLCA1 mRNA15598610
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CLCA1 mRNA26496021
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of CLCA1 mRNA26945725
D004958EstradiolEstradiol results in increased expression of CLCA1 mRNA26945725
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CLCA1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CLCA1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLCA1 mRNA23741332
D002136Calcium, Dietary"Calcium, Dietary results in increased expression of CLCA1 mRNA"15539406
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CLCA1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CLCA1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of CLCA1 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CLCA1 protein22552367
D002922CiguatoxinsCiguatoxins affects the expression of CLCA1 mRNA18353800
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CLCA1 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of CLCA1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLCA1 mRNA21266533
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CLCA1 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CLCA1 mRNA17394237
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CLCA1 mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CLCA1 mRNA"19480007
D004317DoxorubicinDoxorubicin results in increased expression of CLCA1 mRNA21040762
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of CLCA1 mRNA21040762
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CLCA1 mRNA17557909
D005557FormaldehydeFormaldehyde results in decreased expression of CLCA1 mRNA24304932
C039281furanfuran results in increased expression of CLCA1 mRNA27387713
C039281furanfuran results in increased methylation of CLCA1 gene22079235
D019833GenisteinGenistein results in increased expression of CLCA1 mRNA17341692
D006418HemeHeme results in decreased expression of CLCA1 mRNA15539406
D006632HistamineHistamine results in increased expression of CLCA1 mRNA17622767
D007545IsoproterenolIsoproterenol results in increased expression of CLCA1 mRNA20003209
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA]23963992
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CLCA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CLCA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLCA1 mRNA"25620056
C031721naphthalenenaphthalene analog results in increased expression of CLCA1 mRNA24976557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CLCA1 mRNA19812364
C016030pantogabpantogab results in increased expression of CLCA1 mRNA17379144
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA]23963992
D052638Particulate MatterParticulate Matter results in decreased expression of CLCA1 mRNA28655636
D052638Particulate MatterParticulate Matter results in increased expression of CLCA1 protein17520064
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CLCA1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CLCA1 mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of CLCA1 mRNA18445702
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of CLCA1 mRNA26945725
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CLCA1 mRNA23608068
D011374ProgesteroneProgesterone affects the expression of CLCA1 mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of CLCA1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of CLCA1 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of CLCA126549244
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CLCA1 mRNA"16251409
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CLCA1 protein"16251409
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA]23963992
C017947sodium arsenitesodium arsenite results in increased expression of CLCA1 mRNA17350061
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of CLCA1 mRNA21632023
D053260SootSoot results in increased expression of CLCA1 mRNA22461453|2655175
D013629TamoxifenTamoxifen affects the expression of CLCA1 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLCA1 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLCA1 mRNA19933214
C009495titanium dioxidetitanium dioxide results in decreased expression of CLCA1 mRNA23131501|2355797
C009495titanium dioxidetitanium dioxide results in increased expression of CLCA1 mRNA27760801
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CLCA1 mRNA16141432
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of CLCA1 mRNA17982090
D014640VancomycinVancomycin results in decreased expression of CLCA1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CLCA1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CLCA1 protein17520064

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005229intracellular calcium activated chloride channel activity-IBA21873635  
GO:0005254chloride channel activity-TAS9828122  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006816calcium ion transport-IEA-  
GO:0034220ion transmembrane transport-TAS-  
GO:0071456cellular response to hypoxia-IEA-  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005902microvillus-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0042589zymogen granule membrane-IEA-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22731784Increased human Ca(2)(+)-activated Cl(-) channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. (2012 Jun 25)Iwashita HRespir Res