Gene info: ID 118

Gene: ADD1

GENE ID: 118

Synonyms: ADDA

Description: adducin 1

Gene type: protein-coding

Location: 4p16.3

dbXrefs: Ensembl:ENSG00000087274 MIM:102680 Vega:OTTHUMG00000122080 UniprotKB:P35611

RefSeq: NG_012037.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.923e-1 (AD) 3.389e-3 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10488838	chr4:2879608 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PSAP	0.957
RAB1B	0.953
OSBPL2	0.945
GNAO1	0.94
GRINA	0.938
CSNK1E	0.938
FAM168A	0.937
VPS4A	0.933
AMFR	0.932
TSPAN7	0.928

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.872
OR4F29	-0.849
GZMK	-0.272
TFPI2	-0.269
CD48	-0.264
SLAMF6	-0.26
CD8B	-0.259
KLRB1	-0.257
CD3G	-0.254
C2orf83	-0.251

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ADD1 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in increased expression of ADD1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in decreased expression of ADD1 mRNA	11264010
D000638	Amiodarone	Amiodarone affects the expression of ADD1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADD1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of ADD1 mRNA	24449571
D001194	Asbestos	Asbestos affects the expression of ADD1 mRNA	17297452
D001553	Benzbromarone	Benzbromarone affects the expression of ADD1 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ADD1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADD1 mRNA	19770486
C006780	bisphenol A	bisphenol A affects the expression of ADD1 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased expression of ADD1 protein	28903499
D002994	Clofibrate	Clofibrate affects the expression of ADD1 mRNA	19483382
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ADD1 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADD1 mRNA	20106945
C000944	dicrotophos	dicrotophos results in increased expression of ADD1 mRNA	28302478
D004221	Disulfiram	Disulfiram results in decreased expression of ADD1 mRNA	20530235
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ADD1 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ADD1 mRNA	17475347
D005001	Ethionine	Ethionine affects the expression of ADD1 mRNA	19483382
D018120	Finasteride	Finasteride results in increased expression of ADD1 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of ADD1 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in decreased expression of ADD1 mRNA	19167457
D005839	Gentamicins	Gentamicins results in decreased expression of ADD1 mRNA	22061828
C492448	ICG 001	ICG 001 results in decreased expression of ADD1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADD1 mRNA	25613284
D007854	Lead	Lead affects the splicing of ADD1 mRNA	28903495
D007854	Lead	Lead results in decreased expression of ADD1 mRNA	19921347
C015329	lycopene	lycopene results in decreased expression of ADD1 mRNA	16886892
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of ADD1 mRNA	20353558
D008727	Methotrexate	Methotrexate results in increased expression of ADD1 mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of ADD1 protein	27012723
C030957	methylmercury II	methylmercury II results in increased expression of ADD1 mRNA	17905399
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ADD1 mRNA"	26251327
C051752	nefazodone	nefazodone results in increased expression of ADD1 mRNA	24136188
C028007	nickel monoxide	nickel monoxide results in decreased expression of ADD1 mRNA	19167457
C012655	nimesulide	nimesulide results in increased expression of ADD1 mRNA	24136188
D009853	Omeprazole	Omeprazole affects the expression of ADD1 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in decreased expression of ADD1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of ADD1 mRNA	23811191
C006253	pirinixic acid	pirinixic acid affects the expression of ADD1 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of ADD1 mRNA	19162173
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ADD1 mRNA	19162173
C045950	propiconazole	propiconazole results in decreased expression of ADD1 mRNA	19363144\|2127805
D011441	Propylthiouracil	Propylthiouracil affects the expression of ADD1 mRNA	19483382
D011748	Pyrogallol	Pyrogallol results in increased expression of ADD1 mRNA	20362636
C106263	rostafuroxin	[LSS gene polymorphism co-treated with HSD3B1 gene polymorphism co-treated with ABCB1 gene polymorphism co-treated with ADD1 gene polymorphism co-treated with ADD3 gene polymorphism] affects the susceptibility to rostafuroxin	21106941
D012524	Sarin	Sarin results in decreased expression of ADD1 mRNA	19522546
D012643	Selenium	Selenium results in increased expression of ADD1 mRNA	19244175
D018038	Sodium Selenite	Sodium Selenite results in increased expression of ADD1 mRNA	18175754
D013467	Sulindac	Sulindac results in increased expression of ADD1 mRNA	24136188
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ADD1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADD1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADD1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of ADD1 mRNA	19483382
D013893	Thiram	Thiram results in decreased expression of ADD1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of ADD1 mRNA	16604517
D014635	Valproic Acid	Valproic Acid affects the expression of ADD1 mRNA	25979313
C025643	vinclozolin	vinclozolin affects the expression of ADD1 mRNA	19015723
D014810	Vitamin E	Vitamin E results in increased expression of ADD1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0003779	actin binding	-	TAS	1840603
GO:0005198	structural molecule activity	-	IBA	21873635
GO:0005198	structural molecule activity	-	IEA	-
GO:0005515	protein binding	-	IPI	16289097
GO:0005516	calmodulin binding	-	IEA	-
GO:0008134	transcription factor binding	-	IPI	16289097
GO:0030507	spectrin binding	-	IBA	21873635
GO:0030507	spectrin binding	-	IDA	7642559
GO:0042803	protein homodimerization activity	-	IPI	7642559
GO:0045296	cadherin binding	-	HDA	25468996
GO:0046982	protein heterodimerization activity	-	IPI	7642559
GO:0051015	actin filament binding	-	IBA	21873635
GO:0051015	actin filament binding	-	IDA	7642559

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0006884	cell volume homeostasis	-	IEA	-
GO:0020027	hemoglobin metabolic process	-	IEA	-
GO:0030036	actin cytoskeleton organization	-	IC	3693401
GO:0030218	erythrocyte differentiation	-	IEA	-
GO:0032092	positive regulation of protein binding	-	IDA	3693401 7642559
GO:0035264	multicellular organism growth	-	IEA	-
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	-
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-
GO:0051016	barbed-end actin filament capping	-	IBA	21873635
GO:0051016	barbed-end actin filament capping	-	IDA	8626479
GO:0051017	actin filament bundle assembly	-	IBA	21873635
GO:0051017	actin filament bundle assembly	-	IDA	3693401
GO:0055085	transmembrane transport	-	TAS	-
GO:0071277	cellular response to calcium ion	-	IDA	25978380
GO:1903142	positive regulation of establishment of endothelial barrier	-	IBA	21873635
GO:1903142	positive regulation of establishment of endothelial barrier	-	IDA	25978380
GO:1903393	positive regulation of adherens junction organization	-	IBA	21873635
GO:1903393	positive regulation of adherens junction organization	-	IDA	25978380

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	16289097
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IDA	25978380
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	colocalizes_with	IDA	25978380
GO:0005913	cell-cell adherens junction	-	IBA	21873635
GO:0005913	cell-cell adherens junction	-	IDA	25978380
GO:0005925	focal adhesion	-	HDA	21423176
GO:0008290	F-actin capping protein complex	-	IDA	8626479
GO:0014069	postsynaptic density	-	IBA	21873635
GO:0016604	nuclear body	-	IDA	-
GO:0044853	plasma membrane raft	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	TAS
R-HSA-381038	XBP1(S) activates chaperone genes	TAS
R-HSA-381070	IRE1alpha activates chaperones	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5223345	Miscellaneous transport and binding events	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-75153	Apoptotic execution phase	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17051589	Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis. (2006 Oct)	Torfs CP	Birth Defects Res A Clin Mol Teratol
21532846	Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular geometry in Caucasians and African Americans: The HyperGEN Study. (2010 Feb 26)	Chauhan K	Int J Mol Epidemiol Genet
27110136	Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. (2016)	Harada M	Int J Gen Med
25816007	A phosphorylation-related variant ADD1-rs4963 modifies the risk of colorectal cancer. (2015)	Shen N	PLoS One
16100725	Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. (2005 Sep 15)	Shaw GM	Am J Med Genet A
23509723	Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population. (2013)	Zhang LN	Biomed Res Int
27616475	Gene variants as risk factors for gastroschisis. (2016 Nov)	Padula AM	Am J Med Genet A