Gene: OLFM3

118427
NOE3|NOELIN3|OPTIMEDIN
olfactomedin 3
protein-coding
1p21.1
Ensembl:ENSG00000118733 MIM:607567 Vega:OTTHUMG00000010941 UniprotKB:Q96PB7
NC_000001.11
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.956e-4 (AD)  7.918e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12731963chr1:101916848 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs1336798chr1:101886314 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs4907956chr1:101847147 (GRCh38.p7)G>Talcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A100.973
C11orf870.972
HCN10.972
GABRG20.971
FRMPD40.971
SCN2A0.97
C3orf800.969
DLGAP10.967
STXBP5L0.967
GABRB20.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.609
CSAG1-0.609
RAB13-0.594
RNF135-0.587
YES1-0.584
MYL3-0.584
REST-0.572
CNN2-0.572
ROM1-0.569
CHST14-0.564

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OLFM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OLFM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of OLFM3 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of OLFM3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OLFM3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OLFM3 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of OLFM3 mRNA22378314
C487081belinostatbelinostat results in increased expression of OLFM3 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of OLFM3 mRNA22316170
C006780bisphenol Abisphenol A affects the expression of OLFM3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of OLFM3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of OLFM3 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of OLFM3 mRNA25979313
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of OLFM3 mRNA26272509
D003300CopperCopper deficiency results in increased expression of OLFM3 mRNA26033743
C118739entinostatentinostat results in increased expression of OLFM3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
D007854LeadLead affects the expression of OLFM3 mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of OLFM3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OLFM3 mRNA26272509|2800136
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of OLFM3 mRNA"29244179
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of OLFM3 mRNA17616710
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of OLFM3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of OLFM3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OLFM3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of OLFM3 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of OLFM3 mRNA24780913
D013629TamoxifenTamoxifen results in decreased expression of OLFM3 mRNA25123088
D014212TretinoinTretinoin results in decreased expression of OLFM3 mRNA21934132
D014212TretinoinTretinoin results in increased expression of OLFM3 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of OLFM3 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of OLFM3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OLFM3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of OLFM3 mRNA24383497|2493525
D014640VancomycinVancomycin results in increased expression of OLFM3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OLFM3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12019210  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0042462eye photoreceptor cell development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0030054cell junction-IEA-  
GO:0032281AMPA glutamate receptor complex-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal