Gene: CLCNKB

1188
CLCKB|ClC-K2|ClC-Kb
chloride voltage-gated channel Kb
protein-coding
1p36.13
Ensembl:ENSG00000184908 MIM:602023 Vega:OTTHUMG00000009530 UniprotKB:P51801
NG_013079.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.340e-1 (AD)  9.123e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRQ0.475
SYTL10.455
CDC42BPG0.453
ZDHHC190.449
CIB20.438
UBL4B0.436
GADL10.419
CH25H0.416
CD190.404
SLC15A10.402

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM229A-0.27
INSL5-0.253
TRPV3-0.232
FAM222A-0.229
LYG2-0.228
ZFHX2-0.223
OR9A2-0.222
OR13J1-0.21
ANKRD18A-0.207
TDRD6-0.201

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CLCNKB mRNA"18648102
C496492abrineabrine results in increased expression of CLCNKB mRNA22595364
D020106AcrylamideAcrylamide results in decreased expression of CLCNKB mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLCNKB mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of CLCNKB mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CLCNKB mRNA24763279
D003471CuprizoneCuprizone affects the expression of CLCNKB mRNA26577399
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid analog results in decreased activity of CLCNKB protein"15167890
C118739entinostatentinostat results in increased expression of CLCNKB mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CLCNKB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLCNKB mRNA17942748
C039281furanfuran results in increased expression of CLCNKB mRNA25539665|2619464
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CLCNKB mRNA24763279
D008694MethamphetamineMethamphetamine affects the methylation of CLCNKB promoter26307267
D008694MethamphetamineMethamphetamine results in decreased expression of CLCNKB mRNA26307267
D0084562-Methyl-4-chlorophenoxyacetic Acid2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein15167890
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CLCNKB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLCNKB mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CLCNKB mRNA18978301
D009532NickelNickel results in decreased expression of CLCNKB mRNA25583101
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CLCNKB mRNA"12756304
D010936Plant ExtractsPlant Extracts results in decreased expression of CLCNKB mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of CLCNKB mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of CLCNKB mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of CLCNKB gene28589171
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLCNKB mRNA17942748
D014635Valproic AcidValproic Acid results in increased methylation of CLCNKB gene29154799
D014635Valproic AcidValproic Acid affects the expression of CLCNKB mRNA17292431
D014640VancomycinVancomycin results in increased expression of CLCNKB mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of CLCNKB mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of CLCNKB mRNA26682919
D019287Zinc SulfateZinc Sulfate results in decreased expression of CLCNKB mRNA12756304
C088658zoledronic acidzoledronic acid results in decreased expression of CLCNKB mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005247voltage-gated chloride channel activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007588excretion-TAS9326936  
GO:0034220ion transmembrane transport-TAS-  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8041726  
GO:0034707chloride channel complex-IEA-  
KEGG ID KEGG Term
hsa04966Collecting duct acid secretion
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res