Gene: CLU

1191
AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
clusterin
protein-coding
8p21.1
Ensembl:ENSG00000120885 MIM:185430 Vega:OTTHUMG00000102114 UniprotKB:P10909
NG_027845.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.153e-2 (AD)  3.797e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18931633chr8:27470575CLU2.300e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD810.941
TMBIM60.934
FYN0.922
ITM2C0.92
HSPB80.895
TPP10.892
ENO10.887
ALDH20.887
CPE0.884
CYB5R30.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.804
OR4F29-0.79
FER1L6-0.255
CETP-0.249
GADL1-0.241
LY9-0.223
KRT72-0.215
DPPA4-0.214
OR52E4-0.214
SCARA5-0.209

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea affects the expression of CLU mRNA"7654323
C0326681-nitropyrene1-nitropyrene results in decreased expression of CLU mRNA19041380
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of CLU mRNA"11509743
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLU mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLU mRNA"17547211
C0005974662-(4-(3-(1-(4-(2-aminopyrimidin-5-yl)phenyl)-1-cyclopropylethyl)-(1,2,4)oxadiazol-5-yl)pyrazol-1-yl)-N,N-dimethylacetamide"2-(4-(3-(1-(4-(2-aminopyrimidin-5-yl)phenyl)-1-cyclopropylethyl)-(1,2,4)oxadiazol-5-yl)pyrazol-1-yl)-N,N-dimethylacetamide results in increased expression of CLU mRNA"28167222
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of CLU mRNA"22952946
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of CLU mRNA"27466211
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CLU mRNA"20206263
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CLU mRNA]"19467301
C5328893-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol results in increased secretion of CLU protein21258088
C0312853-xylene3-xylene results in increased expression of CLU mRNA12815608
C5562954-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CLU mRNA"18289764
C0047594,4'-dichlorobenzophenone"4,4'-dichlorobenzophenone inhibits the reaction [Dihydrotestosterone results in decreased expression of CLU mRNA]"21291947
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CLU mRNA"19561079
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of CLU mRNA10822019|1468916
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CLU mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of CLU mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of CLU mRNA20623750
D000082AcetaminophenAcetaminophen results in increased expression of CLU mRNA12883083|1752207
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CLU mRNA23630614
D013196Dihydrotestosterone"4,4'-dichlorobenzophenone inhibits the reaction [Dihydrotestosterone results in decreased expression of CLU mRNA]"21291947
D013196DihydrotestosteroneDichlorodiphenyl Dichloroethylene inhibits the reaction [Dihydrotestosterone results in decreased expression of CLU mRNA]21291947
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of CLU mRNA21291947
D000537Aluminum Oxide"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CLU protein"25598225
D000641AmmoniaAmmonia results in increased expression of CLU mRNA11592597
D000643Ammonium ChlorideAmmonium Chloride inhibits the reaction [CLU protein results in increased degradation of ATP7B protein modified form]21242307
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLU mRNA16483693
D000666Amphotericin BAmphotericin B affects the expression of CLU mRNA20623750
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CLU mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CLU mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CLU mRNA22521957|2782922
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CLU mRNA"23917077
D001205Ascorbic AcidAscorbic Acid results in increased expression of CLU mRNA15372504
C547126AZM551248AZM551248 results in increased expression of CLU mRNA22323515
D001414BacitracinBacitracin results in increased expression of CLU mRNA18289764
C028559bathocuproine sulfonate[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]21242307
C028559bathocuproine sulfonate[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]21242307
C487081belinostatbelinostat promotes the reaction [decitabine results in increased expression of CLU mRNA]19234609
C487081belinostatbelinostat promotes the reaction [decitabine results in increased expression of CLU protein]19234609
C487081belinostatbelinostat results in increased expression of CLU mRNA19606018
C487081belinostatbelinostat results in increased expression of CLU protein19234609
D001554BenzeneBenzene results in decreased expression of CLU mRNA19162166
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CLU mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLU mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLU mRNA15034205|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CLU mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CLU mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CLU mRNA19619570|2118537
D004958EstradiolEstradiol affects the expression of CLU mRNA15598610
D004958Estradiol"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of CLU mRNA"11509743
D004958Estradiol[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of CLU mRNA11509743
D004958EstradiolEstradiol results in decreased expression of CLU mRNA12370124
D004958EstradiolEstradiol results in increased expression of CLU mRNA11509743|1528915
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of CLU mRNA26945725
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of CLU mRNA11375906
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of CLU protein11375906
D004958EstradiolEstradiol results in decreased expression of CLU mRNA20381596|2694572
C053541bicalutamidebicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]17148459
C053541bicalutamidebicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]17148459|1732574
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of CLU mRNA15912405
C006780bisphenol A"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
C006780bisphenol A"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
C006780bisphenol Abisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]26320837
C006780bisphenol Abisphenol A results in increased expression of CLU mRNA29275510
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]26320837
C006780bisphenol Abisphenol A inhibits the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
C006780bisphenol Abisphenol A results in increased expression of CLU mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CLU protein21536718
D000069286BortezomibBortezomib results in increased expression of CLU mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CLU mRNA15963989
D002087ButyratesButyrates results in increased expression of CLU mRNA16042588
D002087ButyratesButyrates results in increased expression of CLU mRNA14674679
D002104CadmiumCLU protein binds to Cadmium23896426
D002104CadmiumCadmium results in increased expression of and results in increased secretion of CLU protein19288494
D002104CadmiumNimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]19288494
D002104CadmiumSLC30A1 inhibits the reaction [Cadmium results in increased expression of and results in increased secretion of CLU protein]19288494
D002104CadmiumCadmium results in increased expression of CLU mRNA12890491
D019256Cadmium ChlorideCadmium Chloride affects the expression of CLU mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CLU protein24200859
D019256Cadmium Chloridetetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein]24200859
C006698carbendazimcarbendazim results in decreased expression of CLU mRNA22952946
C006698carbendazimcarbendazim results in increased expression of CLU mRNA27466211
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CLU mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CLU mRNA17522070
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CLU mRNA18636392
D002725ChloroformChloroform results in increased expression of CLU mRNA17522070
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CLU mRNA26272509
D002738ChloroquineChloroquine affects the localization of CLU protein8616629
D002992ClofenapateClofenapate results in increased expression of CLU mRNA12971794
D002994ClofibrateClofibrate results in decreased expression of CLU mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of CLU mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of CLU protein16827160
D003042CocaineCocaine affects the expression of CLU protein11299316
D003042CocaineCocaine results in increased expression of CLU mRNA11299316
D003300CopperCLU protein binds to Copper23896426
D003300Copper[CLU protein co-treated with ATP7B protein] results in decreased export of Copper21242307
D003300CopperCLU protein results in decreased export of Copper21242307
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CLU mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CLU mRNA15467011
D019327Copper SulfateCopper Sulfate affects the expression of CLU mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLU mRNA"19167446
C015763cumenecumene results in increased expression of CLU mRNA18648096
C015763cumeneKRAS gene mutant form promotes the reaction [cumene results in increased expression of CLU mRNA]18648096
C029892cupric chloridecupric chloride promotes the reaction [CLU protein binds to ATP7A protein]21242307
C029892cupric chloridecupric chloride promotes the reaction [CLU protein binds to ATP7B protein]21242307
C029892cupric chloridecupric chloride results in increased expression of CLU mRNA17211630
C030973cupric oxidecupric oxide results in increased expression of CLU mRNA22077320
D003471CuprizoneCuprizone results in increased expression of CLU mRNA26577399
C004632cyanuric acid[cyanuric acid co-treated with melamine] results in increased expression of CLU mRNA21784140
C004632cyanuric acid[melamine co-treated with cyanuric acid] results in increased expression of CLU mRNA23022069
C004632cyanuric acid[melamine co-treated with cyanuric acid] results in increased expression of CLU protein22610612|2302206
D016572CyclosporineCyclosporine results in decreased expression of CLU mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CLU mRNA21865292
D015853Cysteine Proteinase InhibitorsCysteine Proteinase Inhibitors inhibits the reaction [Penicillins results in increased expression of CLU mRNA]23266720
D015853Cysteine Proteinase InhibitorsCysteine Proteinase Inhibitors inhibits the reaction [Penicillins results in increased expression of CLU protein]23266720
D003606DacarbazineCLU protein affects the susceptibility to Dacarbazine15955107
C004742daidzeindaidzein results in decreased expression of CLU mRNA10822019
C515055darinaparsindarinaparsin results in increased expression of CLU mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CLU mRNA]22535156
D000069439DasatinibDasatinib results in increased expression of CLU mRNA20579391
C014347decitabinebelinostat promotes the reaction [decitabine results in increased expression of CLU mRNA]19234609
C014347decitabinebelinostat promotes the reaction [decitabine results in increased expression of CLU protein]19234609
C014347decitabine[decitabine co-treated with Depsipeptides] results in increased expression of CLU mRNA17064661
C014347decitabinedecitabine results in decreased methylation of CLU promoter19234609
C014347decitabinedecitabine results in increased expression of CLU mRNA19234609
C014347decitabinedecitabine results in increased expression of CLU protein19234609
C415250deferasiroxdeferasirox results in increased expression of CLU protein21439361
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in increased expression of CLU mRNA17064661
D047630DepsipeptidesDepsipeptides results in increased expression of CLU mRNA17064661
D003907DexamethasoneDexamethasone results in decreased expression of CLU mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of CLU mRNA17522070|2003205
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CLU mRNA]20032058
D003958DiamideDiamide promotes the reaction [CLU protein binds to ATP7A protein]21242307
D003958DiamideDiamide promotes the reaction [CLU protein binds to ATP7B protein]21242307
D016190CarboplatinCarboplatin results in decreased expression of CLU mRNA18172885
C061481dibenzoylmethanedibenzoylmethane results in decreased expression of CLU mRNA17942926
C061481dibenzoylmethane[sulforafan co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA17942926
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLU mRNA21266533|2174549
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CLU protein21745491
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of CLU mRNA]27392435
D002945CisplatinCLU protein results in decreased susceptibility to Cisplatin15955107
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of CLU mRNA]27392435
D002945CisplatinCisplatin results in increased expression of CLU protein28904298|2905111
D002945CisplatinCisplatin results in increased expression of CLU mRNA21151649
D002945CisplatinCisplatin affects the expression of CLU mRNA20623750
D002945CisplatinCisplatin results in decreased expression of CLU mRNA18172885
D002945CisplatinCisplatin results in decreased expression of CLU protein22023808
D002945CisplatinCisplatin results in increased expression of CLU mRNA18289764
D002945CisplatinCisplatin results in increased expression of CLU protein15033597|2071678
D002945CisplatinCisplatin results in increased secretion of CLU protein28885000
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene inhibits the reaction [Dihydrotestosterone results in decreased expression of CLU mRNA]21291947
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of CLU mRNA9007049
D004008DiclofenacDiclofenac results in increased expression of CLU protein23506792
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein"25772430
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CLU mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of CLU mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of CLU mRNA19467301
D004041Dietary FatsDietary Fats results in increased expression of CLU mRNA21852083
D004041Dietary Fatsresveratrol promotes the reaction [Dietary Fats results in increased expression of CLU mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CLU mRNA17558187
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA16158176
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA14656948
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CLU mRNA18544905
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CLU mRNA15766595
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CLU mRNA12370124
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CLU mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CLU mRNA17558187|2165843
D002117CalcitriolCalcitriol results in increased expression of CLU8593782
D002117CalcitriolCalcitriol results in increased expression of CLU protein9528999
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of CLU mRNA27638505
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of CLU mRNA20886546|2387685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CLU mRNA"22485181
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of CLU mRNA"27840820
D004147DioxinsDioxins affects the expression of CLU mRNA20463971
D004280DobutamineDobutamine results in increased expression of CLU protein15052282
D004317Doxorubicin"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
D004317Doxorubicin"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]"26320837
D004317Doxorubicinbisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]26320837
D004317DoxorubicinCLU mRNA results in decreased susceptibility to Doxorubicin16322897
D004317DoxorubicinDoxorubicin results in increased expression of CLU mRNA26320837
D004317Doxorubicinfulvestrant inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]26320837
D004317Doxorubicin[Doxorubicin co-treated with Razoxane] results in decreased expression of CLU protein12714334
D004317DoxorubicinDoxorubicin results in decreased expression of CLU protein12714334
D004317DoxorubicinDoxorubicin results in increased expression of CLU mRNA15033991|2201664
D004317DoxorubicinDoxorubicin results in increased secretion of CLU protein28885000
D004656EnalaprilEnalapril results in decreased expression of CLU protein12193663
C118739entinostatentinostat results in increased expression of CLU mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C074283estradiol 3-benzoateestradiol 3-benzoate affects the expression of CLU mRNA15925091
C015854estradiol valerateestradiol valerate results in increased expression of CLU protein9037392
C015854estradiol valerateVitamin E inhibits the reaction [estradiol valerate results in increased expression of CLU protein]9037392
D000431EthanolEthanol results in increased expression of CLU mRNA15963989
D000431EthanolEthanol results in increased expression of CLU mRNA28069986
D004997Ethinyl Estradiolbisphenol A inhibits the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CLU mRNA11331651|1735126
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CLU mRNA10822019|1468916
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
D004997Ethinyl EstradiolGenistein promotes the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
C054207etomoxiretomoxir results in increased expression of CLU mRNA19234235
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA16158176
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA14656948
D005485FlutamideFlutamide affects the expression of CLU mRNA15519604
D005485FlutamideFlutamide inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]11376863
D005485FlutamideFlutamide results in decreased expression of CLU mRNA17558187
D005485FlutamideFlutamide results in increased expression of CLU mRNA15590119|1588526
D005492Folic AcidFolic Acid results in increased expression of CLU mRNA1482756
D005492Folic AcidFolic Acid results in increased expression of CLU mRNA1482756
D005557FormaldehydeFormaldehyde results in increased expression of CLU mRNA20655997
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CLU mRNA]]26320837
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
C056933fumonisin B1fumonisin B1 results in increased expression of CLU mRNA16221962
C039281furanfuran results in increased expression of CLU mRNA15120968
C056507gemcitabineCLU protein affects the susceptibility to gemcitabine19007378
C056507gemcitabinegemcitabine results in increased expression of CLU protein19007378
D019833GenisteinGenistein results in increased expression of CLU mRNA15289156
D019833GenisteinGenistein affects the expression of CLU mRNA11331651
D019833GenisteinGenistein promotes the reaction [Ethinyl Estradiol results in decreased expression of CLU mRNA]16639590
D019833GenisteinGenistein results in decreased expression of CLU mRNA14689164|2038159
D019833GenisteinIsoflavones inhibits the reaction [Genistein results in decreased expression of CLU mRNA]20381596
D005839GentamicinsGentamicins results in increased expression of CLU mRNA25034533
D005839GentamicinsGentamicins results in increased expression of CLU protein25034533
D005839GentamicinsGentamicins results in increased expression of CLU protein28904298
D005839GentamicinsGentamicins results in increased expression of CLU mRNA17636248|1828976
D005839GentamicinsGentamicins results in increased expression of CLU protein26779593
D005839GentamicinsGentamicins results in increased secretion of CLU protein20816719
D005839GentamicinsSodium Fluoride inhibits the reaction [Gentamicins results in increased expression of CLU mRNA]26779593
D005839GentamicinsSodium Fluoride inhibits the reaction [Gentamicins results in increased expression of CLU protein]26779593
C424943glutamyl-Se-methylselenocysteineglutamyl-Se-methylselenocysteine results in decreased expression of CLU mRNA11306469
D005978GlutathioneGlutathione deficiency results in increased expression of CLU mRNA15345336
C001335hexachlorobutadienehexachlorobutadiene results in increased expression of CLU protein21259293
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [CLU protein binds to ATP7A protein]21242307
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [CLU protein binds to ATP7B protein]21242307
D007052IbuprofenIbuprofen affects the expression of CLU mRNA17070997
D007529IsoflavonesIsoflavones inhibits the reaction [Genistein results in decreased expression of CLU mRNA]20381596
D007545IsoproterenolIsoproterenol results in increased expression of CLU mRNA20003209
D007545IsoproterenolIsoproterenol results in increased expression of CLU protein15052282
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of CLU mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of CLU mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CLU mRNA24796395|2675264
D007649KetamineKetamine results in increased expression of CLU mRNA20080153
D007654KetoconazoleKetoconazole affects the expression of CLU mRNA18289764
D007654KetoconazoleKetoconazole results in decreased expression of CLU mRNA17558187
D048628KetolidesKetolides analog affects the expression of CLU mRNA24967691
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CLU mRNA18544905
D007854LeadLead affects the expression of CLU mRNA28903495
C533894LG 100815LG 100815 results in increased expression of CLU mRNA16951191
D001556LindaneLindane results in increased expression of CLU protein17997001
C002385linsidominelinsidomine results in increased oxidation of CLU protein28086193
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein"25772430
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CLU mRNA"11578593
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CLU protein"25772430
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CLU mRNA12057914
C081064LY 231617LY 231617 affects the expression of CLU mRNA8915593
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CLU mRNA21641980
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA18386188
D008468MeclizineMeclizine affects the expression of CLU protein12388792
D008535MegestrolMegestrol affects the expression of CLU protein12388792
C011907melamine[cyanuric acid co-treated with melamine] results in increased expression of CLU mRNA21784140
C011907melamine[melamine co-treated with cyanuric acid] results in increased expression of CLU mRNA23022069
C011907melamine[melamine co-treated with cyanuric acid] results in increased expression of CLU protein22610612|2302206
C011907melaminemelamine results in increased expression of CLU23052191
D008627Mercuric ChlorideMercuric Chloride affects the expression of CLU mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CLU mRNA16507785
D017669Mercury CompoundsMercury Compounds results in increased expression of CLU protein22715704
D009921MetaproterenolMetaproterenol results in increased expression of CLU protein15052282
D008704MethazolamideMethazolamide affects the expression of CLU protein12388792
C013598methoxyacetic acidCLU protein affects the susceptibility to methoxyacetic acid11906924
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of and results in increased secretion of CLU protein15840169
C013598methoxyacetic acidomega-Agatoxin IVA inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]15840169
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of and results in increased secretion of CLU protein14656996
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of CLU mRNA9314588
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of CLU protein9314588
C013598methoxyacetic acidNifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]14656996
C013598methoxyacetic acidomega-Conotoxin GVIA inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]14656996
D008731Methoxychlor[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of CLU mRNA11509743
D008731MethoxychlorMethoxychlor results in increased expression of CLU protein19202561
C005219methyl cellosolvemethyl cellosolve results in increased expression of CLU mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLU mRNA23458150
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CLU mRNA17412507
C008493methylselenic acidmethylselenic acid affects the expression of CLU mRNA14617803
D015741Metribolonebicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]17148459
D015741Metribolonebicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]17148459|1732574
D015741MetriboloneMetribolone promotes the reaction [AR protein binds to CLU enhancer]17148459
D015741MetriboloneMetribolone results in decreased expression of CLU mRNA alternative form17148459
D015741MetriboloneMetribolone results in increased expression of CLU mRNA17010196|1714845
D015741MetriboloneMetribolone results in increased expression of CLU mRNA alternative form17148459
D015741MetriboloneMetribolone results in increased expression of CLU protein17148459|1732574
D008942MitoxantroneCLU protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CLU mRNA20886546|2387685
D009151Mustard GasMustard Gas results in increased expression of CLU mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CLU mRNA"25554681
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CLU protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLU mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CLU mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CLU mRNA17522070|1828976
D010866NatamycinNatamycin results in increased expression of CLU mRNA22863853
D009532NickelCLU protein binds to Nickel23896426
D009532NickelNickel affects the expression of CLU mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CLU mRNA]14575637
D009532NickelNickel analog results in decreased expression of CLU protein alternative form25144474
D009543NifedipineNifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]14656996
D009553NimodipineNimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]19288494
D009553NimodipineNimodipine inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D005996NitroglycerinNitroglycerin results in decreased expression of CLU mRNA12102619
C025256nonylphenolnonylphenol results in decreased expression of CLU mRNA17558187
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CLU mRNA20971185
D009761NystatinNystatin results in increased expression of CLU mRNA22863853
C025589ochratoxin Aochratoxin A results in increased expression of CLU mRNA12700408|1830870
C025589ochratoxin Aochratoxin A results in increased expression of CLU protein18308701
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of CLU mRNA"16951191
C474055octylphenoloctylphenol results in decreased expression of CLU mRNA17558187
D019319Okadaic AcidOkadaic Acid results in increased expression of CLU mRNA23561263
C076029olanzapineolanzapine affects the phosphorylation of CLU protein25821032
D020867omega-Agatoxin IVAomega-Agatoxin IVA inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]15840169
D020866omega-Conotoxin GVIAomega-Conotoxin GVIA inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein]14656996
C016340o,p'-DDT"o,p'-DDT results in decreased expression of CLU mRNA"10822019
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CLU mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CLU mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of CLU mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of CLU mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CLU mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CLU mRNA]17655762
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CLU mRNA]22535156
D010126OzoneOzone results in increased expression of CLU mRNA12763052
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CLU mRNA18636392
D017239PaclitaxelCLU protein results in decreased susceptibility to Paclitaxel15955107|1630873
D000073878Palm OilPalm Oil results in decreased expression of CLU mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CLU mRNA26272509
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA18386188
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of CLU mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of CLU mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CLU mRNA]17655762
D052638Particulate Matter[CLU gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of CLU mRNA21222557|2122255
D052638Particulate MatterParticulate Matter results in decreased expression of CLU protein alternative form25144474
D052638Particulate MatterParticulate Matter results in increased expression of CLU mRNA21708214
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CLU mRNA18593933
D010396Penicillamine[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]21242307
D010396Penicillamine[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]21242307
D010406PenicillinsCysteine Proteinase Inhibitors inhibits the reaction [Penicillins results in increased expression of CLU mRNA]23266720
D010406PenicillinsCysteine Proteinase Inhibitors inhibits the reaction [Penicillins results in increased expression of CLU protein]23266720
D010406PenicillinsPenicillins results in increased expression of CLU mRNA23266720
D010406PenicillinsPenicillins results in increased expression of CLU protein23266720
D010433PentylenetetrazolePentylenetetrazole affects the expression of CLU mRNA21503142
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CLU mRNA19162173|2131816
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CLU mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CLU protein26879310
D010578PetroleumPetroleum results in increased expression of CLU protein24106129
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of CLU mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of CLU mRNA9512930
D010656PhenylephrinePhenylephrine results in increased expression of CLU mRNA19443575
D010656PhenylephrinePhenylephrine results in increased expression of CLU protein19443575
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLU mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CLU mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of CLU mRNA16221962
C006253pirinixic acidpirinixic acid results in increased expression of CLU mRNA17426115
D010938Plant OilsPlant Oils results in increased expression of CLU mRNA23370395
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of CLU mRNA26945725
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased expression of CLU mRNA12370124
C019536potassium bromatepotassium bromate results in increased expression of CLU protein23159986|2358825
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CLU mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CLU mRNA18332044
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CLU mRNA28903501
C035988procymidoneprocymidone results in increased expression of CLU mRNA12563111|1559011
C035988procymidone[vinclozolin co-treated with procymidone] results in increased expression of CLU mRNA12563111
D011374ProgesteroneProgesterone results in increased expression of CLU mRNA20726854
D011441PropylthiouracilPropylthiouracil affects the expression of CLU mRNA7819453
D011441PropylthiouracilPropylthiouracil results in decreased expression of CLU mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CLU mRNA16202921
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CLU mRNA12370124
D011929Razoxane[Doxorubicin co-treated with Razoxane] results in decreased expression of CLU protein12714334
D011929RazoxaneRazoxane results in decreased expression of CLU protein12714334
C059514resveratrolMIR137 mRNA affects the reaction [resveratrol results in increased expression of CLU mRNA]25505154
C059514resveratrolresveratrol results in increased expression of CLU mRNA25505154
C059514resveratrolMIR137 mRNA affects the reaction [resveratrol results in increased expression of CLU mRNA]25505154
C059514resveratrolresveratrol results in increased expression of CLU mRNA25505154
C059514resveratrolresveratrol promotes the reaction [Dietary Fats results in increased expression of CLU mRNA]21852083
C116926rofecoxibrofecoxib results in increased expression of CLU mRNA17070997
C037663ropivacaineCLU protein inhibits the reaction [ropivacaine results in increased cleavage of PARP1 protein]15538973
C037663ropivacaineCLU protein inhibits the reaction [ropivacaine results in increased expression of CASP3 protein]15538973
C037663ropivacaineCLU protein results in decreased susceptibility to ropivacaine15538973
C037663ropivacaineropivacaine results in decreased expression of CLU protein15538973
C089730rosiglitazonerosiglitazone affects the expression of CLU mRNA20623750
D012402RotenoneRotenone results in increased expression of CLU mRNA22016648
C541923sandostatinLARsandostatinLAR results in decreased expression of CLU mRNA17210224
D012524SarinSarin results in decreased expression of CLU mRNA19522546
C066198SDZ 51641SDZ 51641 results in increased expression of CLU mRNA19234235
C110822SDZ CPI 975SDZ CPI 975 results in increased expression of CLU mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in increased expression of CLU mRNA19234235
D012643SeleniumSelenium results in increased expression of CLU mRNA19244175
C078903seocalcitolseocalcitol results in increased expression of CLU protein9528999
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of CLU protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CLU mRNA25351596
D012834SilverSilver results in increased expression of CLU mRNA26014281
D012834SilverSilver results in increased expression of CLU mRNA27131904
D012906SmokeSmoke analog results in increased expression of CLU mRNA23155386
D012906SmokeSmoke analog results in increased expression of CLU protein23155386
C017947sodium arsenitesodium arsenite results in increased expression of CLU mRNA12377979|1276083
D012969Sodium FluorideSodium Fluoride inhibits the reaction [Gentamicins results in increased expression of CLU mRNA]26779593
D012969Sodium FluorideSodium Fluoride inhibits the reaction [Gentamicins results in increased expression of CLU protein]26779593
D012969Sodium FluorideSodium Fluoride results in increased expression of CLU mRNA23933529
D012969Sodium FluorideSodium Fluoride results in increased expression of CLU protein23933529
D053260SootSoot results in increased expression of CLU mRNA22461453|2655175
D013311StreptozocinStreptozocin results in increased expression of CLU protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of CLU protein]19634143
D020058StyreneStyrene results in decreased expression of CLU mRNA17654243
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CLU mRNA21641980
D012460SulfasalazineSulfasalazine results in increased expression of CLU mRNA22016648
C016766sulforafan[sulforafan co-treated with dibenzoylmethane] results in decreased expression of CLU mRNA17942926
D013467SulindacSulindac affects the expression of CLU protein12388792
D014284TriiodothyronineTriiodothyronine results in increased expression of CLU mRNA7531505
D016559TacrolimusTacrolimus results in increased expression of CLU mRNA21865292
D013629TamoxifenTamoxifen results in decreased expression of CLU mRNA12370124
C021751tanshinonetanshinone results in increased expression of CLU mRNA15849732
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of CLU mRNA11375906
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of CLU protein11375906
D013739TestosteroneTestosterone affects the expression of CLU mRNA17558187
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CLU mRNA]20032058
D043343Testosterone PropionateFlutamide inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]11376863
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of CLU mRNA11376863
D043343Testosterone Propionatevinclozolin inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]11376863
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CLU mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLU mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLU mRNA15667827
D013752TetracyclineTetracycline results in increased expression of CLU mRNA17522070
C017953tetramethylpyrazinetetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein]24200859
D007978LevamisoleLevamisole results in decreased expression of CLU mRNA11139434
D013806TheophyllineTheophylline results in increased expression of CLU mRNA17522070
D013849ThimerosalThimerosal results in decreased expression of CLU mRNA27188386
D013849ThimerosalThimerosal results in increased expression of CLU mRNA16870260
C009495titanium dioxidetitanium dioxide results in increased expression of CLU mRNA19695317
C009495titanium dioxidetitanium dioxide results in increased expression of CLU mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLU mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CLU mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLU protein27818348
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CLU mRNA25729387
D014212TretinoinTretinoin results in increased expression of CLU mRNA18230668|2053023
D014212TretinoinTretinoin results in decreased expression of CLU mRNA21934132
D014212TretinoinTretinoin results in increased expression of CLU mRNA23724009
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CLU mRNA]27469509
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CLU mRNA]14575637
C012589trichostatin Atrichostatin A results in increased expression of CLU mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of CLU protein19234609
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of CLU protein]19634143
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CLU mRNA29024780
C057693troglitazonetroglitazone results in increased expression of CLU mRNA11854617
C113580U 0126U 0126 inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D014635Valproic AcidValproic Acid affects the expression of CLU mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CLU mRNA23179753|2718838
D014639VanadiumVanadium results in increased expression of CLU mRNA19000753
D014640VancomycinVancomycin results in decreased expression of CLU mRNA18930951
D014640VancomycinVancomycin results in increased expression of CLU mRNA18289764
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of CLU mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of CLU mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CLU mRNA]17655762
D001335Vehicle Emissions[CLU gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of CLU mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CLU mRNA19465080
D014700VerapamilVerapamil affects the expression of CLU protein12388792
C025643vinclozolin[vinclozolin co-treated with procymidone] results in increased expression of CLU mRNA12563111
C025643vinclozolinvinclozolin inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]11376863
C025643vinclozolinvinclozolin results in increased expression of CLU mRNA12563111|1559011
D014810Vitamin EVitamin E results in increased expression of CLU mRNA19244175
D014810Vitamin EVitamin E inhibits the reaction [estradiol valerate results in increased expression of CLU protein]9037392
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CLU protein"23811332
C009687wortmanninwortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D015032ZincCLU protein binds to Zinc23896426
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CLU mRNA18593933
D015032ZincNimodipine inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D015032ZincSLC30A1 inhibits the reaction [Zinc results in increased expression of and results in increased secretion of CLU protein]19288494
D015032ZincU 0126 inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D015032Zincwortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]19288494
D015032ZincZinc results in increased expression of and results in increased secretion of CLU protein19288494

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA22179788  
GO:0001540amyloid-beta binding-IPI9228033  23106396  
GO:0005515protein binding-IPI16113678  17043677  17170699  17567961  20195357  25051234  
25451228  26496610  
GO:0016887ATPase activityNOTIDA11123922  
GO:0031625ubiquitin protein ligase binding-IDA20068069  
GO:0044877protein-containing complex binding-IPI22179788  23106396  
GO:0048156tau protein binding-IPI25051234  
GO:0050750low-density lipoprotein particle receptor binding-IPI9228033  
GO:0051087chaperone binding-ISS-  
GO:0051787misfolded protein binding-IBA21873635  
GO:0051787misfolded protein binding-IDA11123922  
GO:0051787misfolded protein binding-IPI19996109  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IDA15857407  
GO:0001774microglial cell activation-IDA15857407  
GO:0001836release of cytochrome c from mitochondria-IC16113678  
GO:0002576platelet degranulation-TAS-  
GO:0006629lipid metabolic process-NAS2387851  
GO:0006956complement activation-TAS1585460  
GO:0006958complement activation, classical pathway-IEA-  
GO:0009615response to virus-IEP16548883  
GO:0010628positive regulation of gene expression-ISS-  
GO:0017038protein import-IDA24446231  
GO:0019730antimicrobial humoral response-TAS-  
GO:0030449regulation of complement activation-TAS-  
GO:0032286central nervous system myelin maintenance-IMP21543606  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP20068069  
GO:0032463negative regulation of protein homooligomerization-IBA21873635  
GO:0032463negative regulation of protein homooligomerization-IDA22179788  23106396  
GO:0032463negative regulation of protein homooligomerization-IMP16113678  
GO:0032464positive regulation of protein homooligomerization-IDA22179788  
GO:0032760positive regulation of tumor necrosis factor production-IDA15857407  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043691reverse cholesterol transport-TAS16682745  
GO:0045087innate immune response-IEA-  
GO:0045429positive regulation of nitric oxide biosynthetic process-IDA15857407  
GO:0048260positive regulation of receptor-mediated endocytosis-IGI9228033  
GO:0050821protein stabilization-IDA11123922  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP20068069  
GO:0051131chaperone-mediated protein complex assembly-IDA17412999  
GO:0051788response to misfolded protein-IDA19996109  
GO:0060548negative regulation of cell death-IMP21803450  
GO:0060548negative regulation of cell death-TAS23164821  
GO:0061077chaperone-mediated protein folding-IDA11123922  
GO:0061518microglial cell proliferation-IDA15857407  
GO:0061740protein targeting to lysosome involved in chaperone-mediated autophagy-IC9228033  
GO:0061741chaperone-mediated protein transport involved in chaperone-mediated autophagy-IC9228033  
GO:0090201negative regulation of release of cytochrome c from mitochondria-TAS21803450  
GO:1900221regulation of amyloid-beta clearance-IDA24446231  
GO:1901214regulation of neuron death-IDA17412999  
GO:1901214regulation of neuron death-IMP9560017  
GO:1901216positive regulation of neuron death-IDA15857407  
GO:1901216positive regulation of neuron death-IMP15897157  
GO:1901216positive regulation of neuron death-ISS-  
GO:1902004positive regulation of amyloid-beta formation-ISS-  
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage-IMP16113678  
GO:1902430negative regulation of amyloid-beta formation-IDA12047389  17412999  
GO:1902847regulation of neuronal signal transduction-IMP21397462  
GO:1902949positive regulation of tau-protein kinase activity-IMP15897157  
GO:1902998positive regulation of neurofibrillary tangle assembly-IMP15897157  
GO:1903573negative regulation of response to endoplasmic reticulum stress-IMP21803450  
GO:1905892negative regulation of cellular response to thapsigargin-IMP21803450  
GO:1905895negative regulation of cellular response to tunicamycin-IMP21803450  
GO:1905907negative regulation of amyloid fibril formation-IDA22179788  
GO:1905907negative regulation of amyloid fibril formation-TAS9228033  23106396  
GO:1905908positive regulation of amyloid fibril formation-TAS20005821  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-IBA21873635  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic process-IMP20068069  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS23164821  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11123922  16113678  17567961  19996109  
GO:0005622intracellular-TAS23164821  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA25051234  
GO:0005737cytoplasm-IDA9560017  25051234  
GO:0005739mitochondrion-IDA16113678  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-IEA-  
GO:0005856cytoskeletoncolocalizes_withIDA25051234  
GO:0009986cell surface-IDA17567961  
GO:0016020membranecolocalizes_withIDA25051234  
GO:0031012extracellular matrix-HDA23658023  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0031966mitochondrial membrane-IEA-  
GO:0032991protein-containing complex-IDA9228033  17567961  
GO:0034366spherical high-density lipoprotein particle-IDA16682745  
GO:0042583chromaffin granule-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA20068069  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0071944cell peripherycolocalizes_withIDA21803450  
GO:0072562blood microparticle-HDA22516433  
GO:0097418neurofibrillary tangle-IDA9560017  15897157  
GO:0097440apical dendrite-IDA9560017  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-166658Complement cascadeTAS
R-HSA-166665Terminal pathway of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
21912625An exploratory study on CLU, CR1 and PICALM and Parkinson disease. (2011)Gao JPLoS One
24758255Clusterin/Apolipoprotein J immunolocalization on carotid artery is affected by TNF-alpha, cigarette smoking and anti-platelet treatment. (2014 Apr 23)Yanni AELipids Health Dis