Gene: GSTO2

119391
GSTO 2-2|bA127L20.1
glutathione S-transferase omega 2
protein-coding
10q25.1
Ensembl:ENSG00000065621 MIM:612314 Vega:OTTHUMG00000019006 UniprotKB:Q9H4Y5
NG_023363.1
PubMed
0   ANCO-SNPs
ND
13   
8.163e-2 (AD)  8.678e-1 (ND)   (Frontal_Cortex)
6.685e-2 (AD)  9.650e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26589669chr10:106028206GSTO29.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAAF10.745
ZNF6670.745
ZNF5400.733
RABL2A0.731
HKR10.728
CAPRIN20.728
TCERG10.724
DZANK10.724
AGK0.724
IFT1220.721

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.359
OR4F29-0.328
EVC2-0.318
PGF-0.318
C4orf19-0.314
COPZ2-0.309
MTRNR2L9-0.308
MTRNR2L6-0.308
KLRC2-0.305
TMEM51-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of GSTO2 mRNA20932894
D000082AcetaminophenAcetaminophen affects the expression of GSTO2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GSTO2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GSTO2 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of GSTO2 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GSTO2 mRNA24449571
D001151ArsenicGSTO2 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicGSTO2 gene polymorphism affects the susceptibility to Arsenic20045512
D001151ArsenicGSTO2 gene SNP affects the metabolism of Arsenic21094982
D001151ArsenicGSTO2 gene SNP affects the susceptibility to Arsenic21094982
D001151ArsenicGSTO2 protein results in increased metabolism of Arsenic16638819|1841463
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO2 mRNA22120849
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO2 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTO2 mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GSTO2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of GSTO2 mRNA22261036
D004958EstradiolEstradiol affects the expression of GSTO2 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of GSTO2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of GSTO2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of GSTO2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of GSTO2 mRNA25979313
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GSTO2 mRNA19440498
C018021cobaltous chloridecobaltous chloride results in increased expression of GSTO2 mRNA24612858
D019327Copper SulfateCopper Sulfate results in decreased expression of GSTO2 mRNA19549813
C029892cupric chloridecupric chloride affects the expression of GSTO2 mRNA22261036
C014347decitabinedecitabine affects the expression of GSTO2 mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GSTO2 mRNA]27941970
D003976DiazinonDiazinon results in decreased expression of GSTO2 mRNA19440498
D002945CisplatinCisplatin affects the expression of GSTO2 mRNA23300844
D004026DieldrinDieldrin affects the expression of GSTO2 mRNA19440498
C118739entinostatentinostat results in increased expression of GSTO2 mRNA27188386
D004785Environmental PollutantsGSTO2 polymorphism affects the susceptibility to Environmental Pollutants19686770
C492448ICG 001ICG 001 results in increased expression of GSTO2 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of GSTO2 mRNA21396975
C544151jinfukangjinfukang results in increased expression of GSTO2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of GSTO2 mRNA24086573
D007649KetamineKetamine results in increased expression of GSTO2 mRNA20080153
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GSTO2 mRNA23458150
D052998MicrocystinsMicrocystins affects the expression of GSTO2 mRNA19790251
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSTO2 mRNA"25620056
D009532NickelNickel results in decreased expression of GSTO2 mRNA19440498
C022838nickel chloridenickel chloride results in increased expression of GSTO2 mRNA24612858
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSTO2 mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of GSTO2 mRNA26079696
D011794QuercetinQuercetin affects the expression of GSTO2 mRNA21632981
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO2 mRNA22120849
D012834SilverSilver results in increased expression of GSTO2 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of GSTO2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of GSTO2 mRNA29108910
C016104sodium bichromatesodium bichromate results in increased expression of GSTO2 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in increased expression of GSTO2 protein28918527
D012999SomanSoman results in increased expression of GSTO2 mRNA19281266
D013605T-2 ToxinT-2 Toxin results in increased expression of GSTO2 mRNA26141394
D013629TamoxifenTamoxifen results in decreased expression of GSTO2 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSTO2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTO2 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSTO2 mRNA21215274
D013853ThioacetamideThioacetamide results in increased expression of GSTO2 mRNA23411599
D014028Tobacco Smoke PollutionGSTO2 gene SNP affects the susceptibility to Tobacco Smoke Pollution23937118
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GSTO2 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GSTO2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of GSTO2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GSTO2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GSTO2 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-TAS-  
GO:0005515protein binding-IPI25416956  25910212  
GO:0016491oxidoreductase activity-IDA15970797  
GO:0042802identical protein binding-IPI25416956  
GO:0045174glutathione dehydrogenase (ascorbate) activity-IBA21873635  
GO:0045174glutathione dehydrogenase (ascorbate) activity-IDA15970797  
GO:0045174glutathione dehydrogenase (ascorbate) activity-TAS-  
GO:0050610methylarsonate reductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-IDA15970797  
GO:0019852L-ascorbic acid metabolic process-IDA15970797  
GO:0019852L-ascorbic acid metabolic process-TAS-  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IDA15970797  
GO:0071243cellular response to arsenic-containing substance-IDA15970797  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19686770A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma. (2009 Nov 15)Wang YHToxicol Appl Pharmacol
25716313GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder. (2015 Apr)Djukic TInt Urol Nephrol
20472488GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population. (2010 Aug)Kiyohara CParkinsonism Relat Disord
23086268Association of glutathione S-transferase omega gene polymorphisms with progression of head and neck cancer. (2012 Dec)Sanguansin SMol Biol Rep
22044695Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer. (2012 Mar)de Andrade MCancer Prev Res (Phila)
23937118GST-omega genes interact with environmental tobacco smoke on adult level of lung function. (2013 Aug 9)de Jong KRespir Res
23927022Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. (2014 Apr)Stamenkovic MClin Exp Ophthalmol
17194543Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. (2007 Feb 21)Wahner ADNeurosci Lett
19859803No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (2010 Jun)Andonova IEBreast Cancer Res Treat
25505599Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects. (2014 Aug)Berg TPharmacol Res Perspect
19513904Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease. (2009 Aug)Yanbaeva DGFree Radic Res
17903307Framingham Heart Study genome-wide association: results for pulmonary function measures. (2007 Sep 19)Wilk JBBMC Med Genet
25892883Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)Qu KWorld J Gastroenterol