Gene: SERPINA3

12
AACT|ACT|GIG24|GIG25
serpin family A member 3
protein-coding
14q32.13
Ensembl:ENSG00000196136 MIM:107280 Vega:OTTHUMG00000029851 UniprotKB:P01011
NG_012879.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.162e-1 (AD)  2.804e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHI3L10.886
CD440.869
IGFLR10.866
C1R0.861
OSMR0.851
LIMK20.849
TMBIM10.84
TNFRSF1A0.837
TIMP10.836
YBX30.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.557
F7-0.548
NEUROD6-0.548
KIT-0.543
MARCH4-0.533
C1QTNF2-0.529
ABCC12-0.529
SLC7A4-0.523
LHX6-0.52
ADRA1D-0.514

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SERPINA3 mRNA"17690111
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SERPINA3 mRNA17690111
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of SERPINA3 mRNA15982314
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of SERPINA3 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINA3 mRNA17175557|2669055
D000117AcetylglucosamineAcetylglucosamine results in decreased expression of SERPINA3 mRNA18047607
C103303alitretinoinalitretinoin results in increased expression of SERPINA3 mRNA15982314
D000639AmitriptylineAmitriptyline results in increased expression of SERPINA3 mRNA15342952|1717555
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SERPINA3 mRNA24449571
D001241AspirinAspirin results in decreased expression of SERPINA3 mRNA15456535
D001241AspirinAspirin results in increased expression of SERPINA3 mRNA11906190
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SERPINA3 mRNA17690111
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of SERPINA3 mRNA17175557
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SERPINA3 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SERPINA3 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SERPINA3 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SERPINA3 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SERPINA3 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERPINA3 mRNA22316170|2623829
D004958EstradiolEstradiol affects the expression of SERPINA3 mRNA22574217
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SERPINA3 mRNA10811566|1961957
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of SERPINA3 mRNA17404688
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINA3 mRNA]21185374
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SERPINA3 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SERPINA3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SERPINA3 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of SERPINA3 mRNA26191083
D002104CadmiumSERPINA3 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SERPINA3 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SERPINA3 mRNA12160620
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SERPINA3 mRNA24763279
C084597chlorcyclizinechlorcyclizine results in increased expression of SERPINA3 mRNA15342952
D002738ChloroquineChloroquine affects the localization of SERPINA3 protein8616629
D002746ChlorpromazineChlorpromazine results in increased expression of SERPINA3 mRNA15342952|1717555
D015283CitalopramCitalopram results in increased expression of SERPINA3 mRNA17567588
D002997ClomipramineClomipramine results in increased expression of SERPINA3 mRNA15342952|1717555
D003024ClozapineClozapine results in increased expression of SERPINA3 mRNA15342952|1717555
D003300CopperSERPINA3 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of SERPINA3 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of SERPINA3 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of SERPINA3 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SERPINA3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SERPINA3 mRNA28628672
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SERPINA3 mRNA"17690111
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SERPINA3 mRNA10811566
D002117CalcitriolCalcitriol results in increased expression of SERPINA3 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SERPINA3 mRNA21592394
D004316DoxepinDoxepin results in increased expression of SERPINA3 mRNA17567588
D005424FlecainideFlecainide results in increased expression of SERPINA3 mRNA15342952|1717555
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SERPINA3 mRNA17690111
D005473FluoxetineFluoxetine results in increased expression of SERPINA3 mRNA15342952|1717555
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SERPINA3 mRNA24763279
D006220HaloperidolHaloperidol results in increased expression of SERPINA3 mRNA17175557
D017313FenretinideFenretinide results in decreased expression of SERPINA3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SERPINA3 mRNA26339600
C492448ICG 001ICG 001 results in increased expression of SERPINA3 mRNA26191083
D007099ImipramineImipramine results in increased expression of SERPINA3 mRNA15342952|1756758
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SERPINA3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SERPINA3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SERPINA3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SERPINA3 mRNA28628672
D007654KetoconazoleKetoconazole results in increased expression of SERPINA3 mRNA15342952|1717555
D007854LeadLead affects the expression of SERPINA3 mRNA28903495
D007854LeadSERPINA3 protein binds to Lead23896426
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINA3 mRNA"18930950
D017336LoratadineLoratadine results in increased expression of SERPINA3 mRNA15342952
D008628MercuryMercury affects the expression of SERPINA3 protein22030286
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SERPINA3 mRNA23876855
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SERPINA3 mRNA17175557
C066471NCS 382NCS 382 results in decreased expression of SERPINA3 mRNA28119166
D009532NickelNickel results in increased expression of SERPINA3 mRNA24768652|2558310
D009532NickelSERPINA3 protein binds to Nickel23896426
C076029olanzapineolanzapine results in increased phosphorylation of SERPINA3 protein25821032
C016340o,p'-DDT"o,p'-DDT results in increased expression of SERPINA3 mRNA"22609851
C410127PCB 180PCB 180 affects the expression of SERPINA3 mRNA21703328
D010419PentamidinePentamidine results in increased expression of SERPINA3 mRNA15342952
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SERPINA3 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPINA3 protein26879310
D010480PerhexilinePerhexiline results in increased expression of SERPINA3 mRNA15342952|1717555
D028321Plant PreparationsPlant Preparations results in decreased expression of SERPINA3 protein28284660
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SERPINA3 mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of SERPINA3 mRNA17404688
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINA3 mRNA]21185374
D015474IsotretinoinIsotretinoin results in increased expression of SERPINA3 mRNA15982314
C116926rofecoxibrofecoxib results in increased expression of SERPINA3 mRNA17070997
D020280SertralineSertraline results in increased expression of SERPINA3 mRNA15342952|1756758
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SERPINA3 mRNA25895662
D012906SmokeSmoke results in decreased expression of SERPINA3 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of SERPINA3 gene28589171
D013015SotalolSotalol results in increased expression of SERPINA3 mRNA17175557
D013629TamoxifenTamoxifen results in decreased expression of SERPINA3 mRNA17175557
D013629TamoxifenTamoxifen results in increased expression of SERPINA3 mRNA15342952|1717555
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SERPINA3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SERPINA3 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of SERPINA3 mRNA17440010
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINA3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINA3 mRNA20106945|2163298
D013752TetracyclineTetracycline results in increased expression of SERPINA3 mRNA17175557
D013881ThioridazineThioridazine results in increased expression of SERPINA3 mRNA15342952|1717555
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of SERPINA3 mRNA"15342952|1717555
D014212TretinoinTretinoin metabolite results in increased expression of SERPINA3 mRNA15982314
D014212TretinoinTretinoin results in increased expression of SERPINA3 mRNA15982314|2383079
D014236TrichlorfonTrichlorfon results in decreased expression of SERPINA3 protein10599054
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SERPINA3 mRNA18200517
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SERPINA3 mRNA29024780
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINA3 mRNA"18930950
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SERPINA3 gene25487561
C029297vinylidene chloridevinylidene chloride results in increased expression of SERPINA3 mRNA26682919
D015029ZeranolZeranol results in increased expression of SERPINA3 mRNA10811566
D015031ZimeldineZimeldine results in increased expression of SERPINA3 mRNA15342952|1717555
D015032ZincSERPINA3 protein binds to Zinc23896426
C088658zoledronic acidzoledronic acid results in increased expression of SERPINA3 mRNA24714768
C088658zoledronic acidzoledronic acid results in increased secretion of SERPINA3 protein24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS14668352  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-TAS2404007  
GO:0005515protein binding-IPI12709365  14668352  14687906  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006953acute-phase response-IEA-  
GO:0006954inflammatory response-NAS12475184  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0019216regulation of lipid metabolic process-NAS11835318  
GO:0030277maintenance of gastrointestinal epithelium-NAS8647626  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS8647626  9880565  14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA25645918  
GO:0005622intracellular-NAS9880565  
GO:0005634nucleus-TAS14668352  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics
16278826Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. (2006 Jan)Chappell SHum Mutat
15718509Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. (2005 Apr)Slowik AStroke
29459363The Failing Heart Stimulates Tumor Growth by Circulating Factors. (2018 Feb 19)Meijers WCCirculation