Gene: ADD3

120
ADDL|CPSQ3
adducin 3
protein-coding
10q25.1-q25.2
Ensembl:ENSG00000148700 MIM:601568 Vega:OTTHUMG00000019032 UniprotKB:Q9UEY8
NG_051033.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.677e-1 (AD)  5.523e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05214460chr10:111766841ADD32.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KAT2B0.938
EFCAB140.91
ALDH9A10.906
GPM6B0.893
SASH10.892
IL6ST0.892
HSDL20.89
PON20.888
GOLIM40.887
PSAT10.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.566
OR4F5-0.546
RHO-0.434
LIPH-0.388
TRABD2A-0.374
CACNA1F-0.368
GPR68-0.366
NRG1-0.366
FAM160A1-0.362
CALHM1-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C00202917alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol"17alpha-ethynylestr-5(10)-ene-3alpha,17beta-diol results in increased expression of ADD3 mRNA"17275934
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ADD3 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADD3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of ADD3 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ADD3 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ADD3 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of ADD3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADD3 mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of ADD3 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADD3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADD3 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ADD3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ADD3 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADD3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADD3 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADD3 mRNA21802500
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADD3 mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ADD3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADD3 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADD3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADD3 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ADD3 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of ADD3 mRNA23019147
D004958EstradiolEstradiol results in increased expression of ADD3 mRNA19167446|2118537
C044887beta-methylcholinebeta-methylcholine affects the expression of ADD3 mRNA21179406
C095105bexarotenebexarotene results in increased expression of ADD3 mRNA17178900
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADD3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ADD3 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of ADD3 mRNA26794494
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of ADD3 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ADD3 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ADD3 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ADD3 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ADD3 mRNA18804290
D002737ChloropreneChloroprene results in increased expression of ADD3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADD3 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ADD3 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of ADD3 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ADD3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of ADD3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ADD3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ADD3 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ADD3 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of ADD3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ADD3 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of ADD3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADD3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADD3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ADD3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ADD3 mRNA27392435|2759478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ADD3 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ADD3 mRNA25380136
D004221DisulfiramDisulfiram results in decreased expression of ADD3 mRNA20530235
D004237DiuronDiuron results in decreased expression of ADD3 mRNA25152437
D004317DoxorubicinADD3 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADD3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADD3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ADD3 mRNA15576828|1755790
D005419FlavonoidsFlavonoids results in decreased expression of ADD3 mRNA18035473
D005472FluorouracilADD3 protein affects the susceptibility to Fluorouracil16217747
C061365flusilazoleflusilazole results in increased expression of ADD3 mRNA28263823
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADD3 gene20938992
C039281furanfuran results in increased expression of ADD3 mRNA27387713
D005839GentamicinsGentamicins results in increased expression of ADD3 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ADD3 mRNA18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADD3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADD3 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of ADD3 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of ADD3 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADD3 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of ADD3 mRNA21335049
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ADD3 mRNA27392435
D001556LindaneLindane affects the expression of ADD3 mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ADD3 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ADD3 mRNA21641980
D008294MalathionMalathion results in increased expression of ADD3 mRNA19784758
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADD3 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ADD3 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ADD3 promoter"26251327
D008743Methyl ParathionMethyl Parathion affects the expression of ADD3 mRNA19784758
D008743Methyl ParathionMethyl Parathion results in decreased expression of ADD3 mRNA19784758
D008743Methyl ParathionMethyl Parathion results in increased expression of ADD3 mRNA19784758
C008493methylselenic acidmethylselenic acid results in increased expression of ADD3 mRNA12517777
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADD3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADD3 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ADD3 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of ADD3 mRNA18651567
D017239PaclitaxelADD3 protein affects the susceptibility to Paclitaxel16217747
D010278ParathionParathion results in increased expression of ADD3 mRNA19784758
D010634PhenobarbitalPhenobarbital affects the expression of ADD3 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of ADD3 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADD3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ADD3 mRNA18301758|2381119
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADD3 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of ADD3 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADD3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ADD3 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ADD3 mRNA19167446
C106263rostafuroxin[LSS gene polymorphism co-treated with HSD3B1 gene polymorphism co-treated with ABCB1 gene polymorphism co-treated with ADD1 gene polymorphism co-treated with ADD3 gene polymorphism] affects the susceptibility to rostafuroxin21106941
D012643SeleniumSelenium results in decreased expression of ADD3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADD3 mRNA25895662
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ADD3 mRNA21641980
D013629TamoxifenTamoxifen results in increased expression of ADD3 protein modified form17901229
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADD3 mRNA21802500
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ADD3 mRNA]19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADD3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADD3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADD3 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADD3 mRNA25613284
D013893ThiramThiram results in decreased expression of ADD3 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ADD3 mRNA28065790
D019772TopotecanADD3 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of ADD3 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ADD3 mRNA16054129|1614095
C012589trichostatin Atrichostatin A results in increased expression of ADD3 mRNA12445420
D014635Valproic AcidValproic Acid affects the expression of ADD3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ADD3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ADD3 mRNA17963808
D014747VinblastineADD3 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of ADD3 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of ADD3 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of ADD3 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of ADD3 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005198structural molecule activity-IBA21873635  
GO:0005200structural constituent of cytoskeleton-TAS8893809  
GO:0005516calmodulin binding-IEA-  
GO:0030507spectrin binding-IBA21873635  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0051016barbed-end actin filament capping-IBA21873635  
GO:0051017actin filament bundle assembly-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005903brush border-IEA-  
GO:0005911cell-cell junction-IEA-  
GO:0005938cell cortex-IEA-  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-TAS8893809  
GO:0044853plasma membrane raft-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29780256The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients. (2018)Cao LOnco Targets Ther