Gene: TPP1

1200
CLN2|GIG1|LPIC|SCAR7|TPP-1
tripeptidyl peptidase 1
protein-coding
11p15.4
Ensembl:ENSG00000166340 MIM:607998 Vega:OTTHUMG00000133404 UniprotKB:O14773
NG_008653.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.656e-3 (AD)  6.726e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMBIM60.896
CLU0.892
SLC41A10.883
BBS20.88
ACOX10.88
UNG0.879
PRCP0.868
DAG10.862
MAP3K50.855
MTMR30.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.649
OR4F29-0.613
CETP-0.272
OR6C74-0.245
CHP2-0.239
CRH-0.236
SCARA5-0.23
HCRTR1-0.224
GZMK-0.22
ITIH6-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TPP1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of TPP1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of TPP1 mRNA17011747
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TPP1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of TPP1 mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TPP1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TPP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TPP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of TPP1 mRNA20458559
D001554BenzeneBenzene results in decreased expression of TPP1 mRNA20036648
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPP1 mRNA22228805
D001663BilirubinBilirubin results in decreased expression of TPP1 mRNA20196124
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TPP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TPP1 mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of TPP1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of TPP1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of TPP1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of TPP1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TPP1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TPP1 mRNA12419474|1533650
C018475butyraldehydebutyraldehyde results in decreased expression of TPP1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TPP1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TPP1 mRNA25270620
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
D002994ClofibrateClofibrate results in increased expression of TPP1 mRNA25270620
C018021cobaltous chloridecobaltous chloride results in decreased expression of TPP1 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TPP1 mRNA15467011
D003471CuprizoneCuprizone results in increased expression of TPP1 mRNA26577399
C014347decitabinedecitabine affects the expression of TPP1 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TPP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TPP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TPP1 mRNA21266533
D002945CisplatinCisplatin affects the expression of TPP1 mRNA23300844
D002945CisplatinCisplatin results in increased expression of TPP1 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of TPP1 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TPP1 mRNA17005392|1701174
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TPP1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TPP1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TPP1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TPP1 mRNA23649840
C540355fenamidonefenamidone results in increased expression of TPP1 mRNA27029645
D005419FlavonoidsFlavonoids results in increased expression of TPP1 mRNA18035473
D005472FluorouracilFluorouracil affects the expression of TPP1 mRNA16584549
D005485FlutamideFlutamide results in decreased expression of TPP1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of TPP1 mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of TPP1 mRNA16221962
D005839GentamicinsGentamicins results in increased expression of TPP1 protein mutant form11589009
D005839GentamicinsGentamicins results in increased expression of TPP1 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TPP1 mRNA12419474
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TPP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TPP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TPP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TPP1 mRNA28628672
D048628KetolidesKetolides analog results in increased expression of TPP1 mRNA24967691
D007854LeadLead affects the expression of TPP1 mRNA28903495
D007854LeadLead results in decreased expression of TPP1 mRNA19921347
D008627Mercuric ChlorideMercuric Chloride affects the expression of TPP1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TPP1 mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TPP1 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TPP1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TPP1 protein26558463
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TPP1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TPP1 protein"21135415
D009532NickelNickel results in increased expression of TPP1 mRNA24768652
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TPP1 protein19716841
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TPP1 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TPP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TPP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TPP1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TPP1 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of TPP1 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of TPP1 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TPP1 mRNA]17655762
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TPP1 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased activity of TPP1 protein9204212
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TPP1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TPP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TPP1 mRNA22079256
C015586propiverinepropiverine binds to TPP1 protein29273565
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TPP1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of TPP1 mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of TPP1 mRNA19244175
D012643SeleniumSelenium results in increased expression of TPP1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TPP1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of TPP1 mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of TPP1 mRNA20816728
D012969Sodium FluorideSodium Fluoride results in decreased expression of TPP1 protein28918527
D012999SomanSoman results in increased expression of TPP1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of TPP1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TPP1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPP1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of TPP1 mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of TPP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TPP1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of TPP1 gene29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of TPP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of TPP1 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of TPP1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TPP1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TPP1 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of TPP1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of TPP1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IBA21873635  
GO:0004175endopeptidase activity-IDA10965052  
GO:0004175endopeptidase activity-IMP10679303  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI12134079  19941651  21829167  25544563  
GO:0008233peptidase activity-IMP9295267  
GO:0008236serine-type peptidase activity-IMP11054422  
GO:0008240tripeptidyl-peptidase activity-IBA21873635  
GO:0008240tripeptidyl-peptidase activity-IDA10965052  11054422  12134079  
GO:0008240tripeptidyl-peptidase activity-IMP10617131  10679303  
GO:0042277peptide binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IMP9295267  10965052  
GO:0006629lipid metabolic process-TAS9295267  
GO:0007040lysosome organization-ISS-  
GO:0007399nervous system development-IMP9295267  
GO:0007417central nervous system development-IBA21873635  
GO:0030163protein catabolic process-NAS10740217  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0043171peptide catabolic process-IMP9989590  15158442  
GO:0045453bone resorption-IMP8215436  
GO:0050885neuromuscular process controlling balance-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA15317752  19941651  
GO:0005764lysosome-IMP9295267  
GO:0042470melanosome-IEA-  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27084846Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease. (2016 Jun 1)Ohlmeier SAm J Physiol Lung Cell Mol Physiol