Gene: NXPE2

120406
FAM55B
neurexophilin and PC-esterase domain family member 2
protein-coding
11q23.2-q23.3
Ensembl:ENSG00000204361 Vega:OTTHUMG00000168293 UniprotKB:Q96DL1
NC_000011.10
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.284e-1 (AD)  6.478e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBL20.442
QSER10.441
CEP3500.438
CEP780.429
CEP440.427
FER0.426
ALMS10.423
ANKAR0.423
ARAP20.42
ZNF4300.419

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHLDA2-0.29
ELFN1-0.29
CRH-0.265
OR4F16-0.261
ERAS-0.26
PNOC-0.244
GALR2-0.244
NPW-0.243
KCNG2-0.24
PHOX2A-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NXPE2 gene27153756
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NXPE2 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of NXPE2 mRNA20739668
C006780bisphenol Abisphenol A affects the expression of NXPE2 mRNA25181051
D002104CadmiumCadmium results in decreased expression of NXPE2 mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NXPE2 mRNA27339419
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NXPE2 mRNA24535843
C024565ethylene dichlorideethylene dichloride results in decreased expression of NXPE2 mRNA28189721
C039281furanfuran results in decreased expression of NXPE2 mRNA24183702
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NXPE2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NXPE2 mRNA"25620056
D010100OxygenOxygen deficiency results in increased expression of NXPE2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of NXPE2 mRNA]22629407
D052638Particulate MatterParticulate Matter results in decreased expression of NXPE2 mRNA27851901
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NXPE2 mRNA24535843
C006253pirinixic acidpirinixic acid results in decreased expression of NXPE2 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of NXPE2 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NXPE2 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of NXPE2 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NXPE2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NXPE2 mRNA25975270
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NXPE2 mRNA19042947
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NXPE2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24550280  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal