Gene: JAML

120425
AMICA|AMICA1|CREA7-1|CREA7-4|Gm638
junction adhesion molecule like
protein-coding
11q23.3
Ensembl:ENSG00000160593 MIM:609770 Vega:OTTHUMG00000166965 UniprotKB:Q86YT9
NC_000011.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.923e-1 (AD)  9.542e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of JAML mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of JAML gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of JAML mRNA"23195993
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of JAML mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of JAML mRNA24449571
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of JAML mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAML mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAML mRNA21569818|2222880
C006780bisphenol Abisphenol A results in decreased expression of JAML mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of JAML mRNA26079696
D002104CadmiumCadmium results in decreased expression of JAML mRNA24376830
D016572CyclosporineCyclosporine results in decreased expression of JAML mRNA25562108|2798913
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of JAML mRNA28962523
D002945CisplatinCisplatin results in increased expression of JAML mRNA27594783
C546771gardiquimodgardiquimod results in decreased expression of JAML mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of JAML mRNA]28003376
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of JAML mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAML mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of JAML mRNA23086925
C045463leflunomideleflunomide results in increased expression of JAML mRNA28988120
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of JAML mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of JAML mRNA19564919
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of JAML mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of JAML mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of JAML mRNA"25554681
D009532NickelNickel results in decreased expression of JAML mRNA23195993
D009532NickelNickel results in increased expression of JAML mRNA25583101
C006253pirinixic acidpirinixic acid results in decreased expression of JAML mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of JAML mRNA22698814
D011374ProgesteroneProgesterone results in increased expression of JAML mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of JAML mRNA26079696
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of JAML mRNA]28003376
C012526quercitrinquercitrin results in increased expression of JAML mRNA25193878
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of JAML mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of JAML mRNA19564919
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAML mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of JAML mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAML mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of JAML mRNA23557971
D014635Valproic AcidValproic Acid results in decreased expression of JAML mRNA29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of JAML mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IPI12869515  
GO:0042803protein homodimerization activity-IDA12869515  
GO:0050839cell adhesion molecule binding-IPI12869515  15800062  
GO ID GO Term Qualifier Evidence PubMed
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IDA12869515  15800062  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IMP18948633  
GO:0030593neutrophil chemotaxis-IMP15800062  
GO:0035696monocyte extravasation-IMP18948633  
GO:0046629gamma-delta T cell activation-ISS-  
GO:0050776regulation of immune response-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0060054positive regulation of epithelial cell proliferation involved in wound healing-ISS-  
GO:0072672neutrophil extravasation-IMP15800062  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12869515  
GO:0005886plasma membrane-TAS-  
GO:0005923bicellular tight junction-IDA15800062  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24512045Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin T cells. (2014 May)Parlet CPAlcohol Clin Exp Res