Gene: CLPS

1208
-
colipase
protein-coding
6p21.31
Ensembl:ENSG00000137392 MIM:120105 Vega:OTTHUMG00000014578 UniprotKB:P04118
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.923e-3 (AD)  1.486e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRSS10.969
CPA10.968
CELA3A0.968
PNLIP0.956
CTRB10.953
CPB10.922
CTRB20.92
PLA2G1B0.919
CELA3B0.918
GP20.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.233
FGF23-0.205
PSG11-0.199
CYP2A6-0.196
AGTR2-0.196
CCL16-0.196
CRLF2-0.195
HMGA2-0.191
IL4-0.19
NPVF-0.186

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04233(Hydroxyethyloxy)Tri(Ethyloxy)OctaneSmall MoleculeExperimentalTarget
DB08222METHOXYUNDECYLPHOSPHINIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CLPS mRNA"19114083
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLPS mRNA16483693
D001629BezafibrateBezafibrate results in increased expression of CLPS mRNA18787029
C006780bisphenol Abisphenol A results in decreased expression of CLPS mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CLPS promoter22457795
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CLPS mRNA17361019
D004041Dietary FatsDietary Fats results in increased expression of CLPS mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of CLPS mRNA18721800
D019422Dietary SucroseDietary Sucrose results in increased expression of CLPS mRNA26033743
C024565ethylene dichlorideethylene dichloride results in increased expression of CLPS mRNA28189721
D005419FlavonoidsFlavonoids results in increased expression of CLPS mRNA18035473
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CLPS mRNA21782745
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLPS mRNA25613284
C051890irinotecanirinotecan affects the expression of CLPS mRNA20097248
D007501IronIron deficiency results in increased expression of CLPS mRNA19821111
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CLPS mRNA21782745
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CLPS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLPS mRNA"25620056
D000069463Olive Oilorlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]15158758
D000069463Olive Oil[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil15158758
D000069463Olive OilOlive Oil analog affects the expression of CLPS mRNA17349074
D000069463Olive Oil[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil15158758
C055122orlistatorlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]15158758
D010634PhenobarbitalPhenobarbital affects the expression of CLPS mRNA23091169
C014794retinol palmitate[PNLIPRP2 protein co-treated with CLPS protein] results in increased hydrolysis of retinol palmitate16497549
D012834SilverSilver results in increased expression of CLPS mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of CLPS mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CLPS mRNA22539624
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLPS mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CLPS mRNA23409001
D014635Valproic AcidValproic Acid results in increased methylation of CLPS gene29154799
D015032ZincZinc deficiency results in decreased expression of CLPS mRNA15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008047enzyme activator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-NAS2045105  
GO:0007586digestion-IEA-  
GO:0016042lipid catabolic process-IEA-  
GO:0032094response to food-IBA21873635  
GO:0043085positive regulation of catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-192456Digestion of dietary lipidTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19039061Chlamydial LPS and high-sensitivity CRP levels in serum are associated with an elevated body mass index in patients with cardiovascular disease. (2008 Dec)Lajunen TInnate Immun