Gene: CLPTM1

1209
-
CLPTM1, transmembrane protein
protein-coding
19q13.32
Ensembl:ENSG00000104853 MIM:604783 Vega:OTTHUMG00000180849 UniprotKB:O96005
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.361e-1 (AD)  9.950e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRINA0.952
CDIPT0.943
AP3D10.942
OTUD50.941
SIRPA0.94
OGDH0.938
GNAO10.937
PPP2R1A0.937
RHBDD20.936
AGPAT10.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.798
OR4F29-0.74
TFPI2-0.39
CD48-0.39
SLAMF6-0.365
IL18RAP-0.354
VNN2-0.348
KCNJ15-0.344
CLEC6A-0.343
PROK2-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of CLPTM1 mRNA"22101062
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CLPTM1 mRNA"17547211
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLPTM1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of CLPTM1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CLPTM1 gene27153756
D000965AntimonyAntimony results in decreased expression of CLPTM1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of CLPTM1 mRNA17547211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLPTM1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of CLPTM1 mRNA16705744
D004958EstradiolEstradiol results in increased expression of CLPTM1 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of CLPTM1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CLPTM1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CLPTM1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of CLPTM1 mRNA20977926
C584509C646 compoundC646 compound results in decreased expression of CLPTM1 mRNA26191083
D002857ChromiumChromium results in decreased expression of CLPTM1 mRNA17547211
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CLPTM1 mRNA]27941970
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CLPTM1 mRNA17547211
D004221DisulfiramDisulfiram results in decreased expression of CLPTM1 mRNA20530235
D004317DoxorubicinCLPTM1 mRNA affects the susceptibility to Doxorubicin16243817
C069837fullerene C60fullerene C60 results in increased expression of CLPTM1 mRNA19167457
D019833GenisteinGenistein results in decreased expression of CLPTM1 mRNA16705744
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLPTM1 mRNA25613284
C045463leflunomideleflunomide results in decreased expression of CLPTM1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CLPTM1 mRNA"24972896
D008628MercuryMercury results in decreased expression of CLPTM1 mRNA17547211
D008628MercuryMercury results in increased expression of CLPTM1 mRNA16823088
D008727MethotrexateCLPTM1 protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in decreased expression of CLPTM1 mRNA17400583
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CLPTM1 mRNA"20188158
C022838nickel chloridenickel chloride results in decreased expression of CLPTM1 mRNA17547211
C028007nickel monoxidenickel monoxide results in increased expression of CLPTM1 mRNA19167457
D010416PentachlorophenolPentachlorophenol results in decreased expression of CLPTM1 mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CLPTM1 protein26879310
C014153pirimiphos methylpirimiphos methyl results in decreased expression of CLPTM1 mRNA27845199
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CLPTM1 mRNA17547211
D012643SeleniumSelenium results in increased expression of CLPTM1 mRNA19244175
D018038Sodium SeleniteSodium Selenite results in decreased expression of CLPTM1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLPTM1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CLPTM1 mRNA25613284
D013893ThiramThiram results in decreased expression of CLPTM1 mRNA20530235
D014520UrethaneUrethane results in increased expression of CLPTM1 mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of CLPTM1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21903422  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0033081regulation of T cell differentiation in thymus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS9828125  
GO:0009897external side of plasma membrane-ISS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20020508Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism. (2010 Mar)Baroni TJ Cell Physiol