Gene: CCDC38

120935
-
coiled-coil domain containing 38
protein-coding
12q23.1
Ensembl:ENSG00000165972 Vega:OTTHUMG00000170352 UniprotKB:Q502W7
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.350e-2 (AD)  1.496e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LINC004230.443
C3orf840.423
XAGE1A0.422
RSPH4A0.393
FANCD20.39
TMEM1590.388
KLF50.384
C20orf2020.383
LTB4R20.376
GPR1510.375

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD17-0.259
RAPSN-0.258
TMEM253-0.258
ASCL1-0.256
HPR-0.235
ARSE-0.232
S100A1-0.229
RLBP1-0.224
PLA2G5-0.223
REN-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CCDC38 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC38 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of CCDC38 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCDC38 mRNA24982889
D004397FonofosFonofos results in increased methylation of CCDC38 promoter22847954
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CCDC38 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC38 mRNA25613284
D010100OxygenOxygen deficiency results in decreased expression of CCDC38 mRNA24205000
D010278ParathionParathion results in increased methylation of CCDC38 promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCDC38 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of CCDC38 mRNA19690047
C012568terbufosterbufos results in increased methylation of CCDC38 promoter22847954
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC38 mRNA25613284

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IDA25074808  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24786987Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. (2014 May)Wain LVPLoS Genet