Gene: CLTB

1212
LCB
clathrin light chain B
protein-coding
5q35.2
Ensembl:ENSG00000175416 MIM:118970 Vega:OTTHUMG00000130662 UniprotKB:P09497
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.791e-1 (AD)  6.717e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MLF20.972
AP2S10.971
CLTA0.969
CUTA0.966
DYNLRB10.966
ATP6V1F0.964
MRPL280.962
COPRS0.961
CFL10.961
C12orf100.959

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.79
OR4F29-0.761
KCNJ15-0.319
CXCR2-0.315
MTRNR2L6-0.309
IL18RAP-0.308
EBF1-0.307
MTRNR2L9-0.303
FCGR3B-0.3
VNN2-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CLTB mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CLTB mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CLTB mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CLTB mRNA17562736
D020106AcrylamideAcrylamide affects the expression of CLTB mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLTB mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CLTB mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLTB mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CLTB mRNA17258074
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CLTB mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLTB mRNA20106945|2163298
D004958EstradiolEstradiol affects the expression of CLTB mRNA14699072
C006780bisphenol Abisphenol A results in decreased expression of CLTB mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CLTB mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of CLTB mRNA12628495
C515564bromovaninbromovanin results in decreased expression of CLTB protein21419150
D002065BuspironeBuspirone results in increased expression of CLTB mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of CLTB mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CLTB mRNA12832660|1664405
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA20938992
D003024ClozapineClozapine results in decreased expression of CLTB mRNA15860345
C018021cobaltous chloridecobaltous chloride results in increased expression of CLTB mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of CLTB mRNA24386269
D003042CocaineCocaine results in decreased expression of CLTB mRNA12629581|1500967
D019327Copper SulfateCopper Sulfate results in increased expression of CLTB mRNA19549813
D016578Crack CocaineCrack Cocaine results in increased expression of CLTB mRNA12629581
D016572CyclosporineCyclosporine results in decreased expression of CLTB mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of CLTB mRNA25562108
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CLTB mRNA28085963
D004317DoxorubicinDoxorubicin affects the expression of CLTB protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CLTB protein23301498
D018120FinasterideFinasteride results in increased expression of CLTB mRNA24136188
D005485FlutamideFlutamide results in increased expression of CLTB mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA20938992
C039281furanfuran results in increased methylation of CLTB gene22079235
D006220HaloperidolHaloperidol results in decreased expression of CLTB mRNA15860345
C544151jinfukangjinfukang results in decreased expression of CLTB mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CLTB protein17337753
D048628KetolidesKetolides analog results in decreased expression of CLTB mRNA24967691
C045463leflunomideleflunomide results in increased expression of CLTB mRNA24136188
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLTB gene21212295
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CLTB mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of CLTB mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLTB protein25809596
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CLTB mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CLTB mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of CLTB mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CLTB mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLTB mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of CLTB mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of CLTB mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of CLTB mRNA18651567
C012655nimesulidenimesulide results in increased expression of CLTB mRNA24136188
C016030pantogabpantogab results in increased expression of CLTB mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of CLTB mRNA23892564
D010634PhenobarbitalPhenobarbital results in increased expression of CLTB mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of CLTB mRNA22484513
C006253pirinixic acidpirinixic acid results in increased expression of CLTB mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CLTB mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CLTB mRNA19162173
C045950propiconazolepropiconazole results in increased expression of CLTB mRNA21278054
D011794QuercetinQuercetin results in increased expression of CLTB mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CLTB mRNA14699072
D012643SeleniumSelenium results in increased expression of CLTB mRNA19244175
C080703SK&F 83959SK&F 83959 results in increased expression of CLTB protein25852303
C061133tamibarotenetamibarotene results in increased expression of CLTB mRNA15498508
D013629TamoxifenTamoxifen affects the expression of CLTB mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLTB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLTB gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLTB protein16548065
C009495titanium dioxidetitanium dioxide results in increased expression of CLTB mRNA27760801
D014212TretinoinTretinoin results in increased expression of CLTB mRNA15498508|1605412
C406224valdecoxibvaldecoxib results in increased expression of CLTB mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLTB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CLTB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CLTB mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of CLTB mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of CLTB mRNA19136453
D014810Vitamin EVitamin E results in increased expression of CLTB mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11889126  25107275  
GO:0032050clathrin heavy chain binding-IBA21873635  
GO:0042277peptide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0048268clathrin coat assembly-IBA21873635  
GO:0061024membrane organization-TAS-  
GO:0072583clathrin-dependent endocytosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005802trans-Golgi network-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0030118clathrin coat-ISS-  
GO:0030118clathrin coat-NAS3267234  
GO:0030125clathrin vesicle coat-IBA21873635  
GO:0030130clathrin coat of trans-Golgi network vesicle-IEA-  
GO:0030132clathrin coat of coated pit-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045334clathrin-coated endocytic vesicle-NAS25898166  
GO:0060170ciliary membrane-IEA-  
GO:0099631postsynaptic endocytic zone cytoplasmic component-IBA21873635  
KEGG ID KEGG Term
hsa04142Lysosome
hsa04144Endocytosis
hsa05016Huntington's disease
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-190828Gap junction traffickingTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-422475Axon guidanceTAS
R-HSA-432720Lysosome Vesicle BiogenesisTAS
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5140745WNT5A-dependent internalization of FZD2, FZD5 and ROR2TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2865110Influence of cimetidine, sulfinpyrazone, and cigarette smoking on theobromine metabolism in man. (1985 Sep-Oct)Miners JODrug Metab Dispos