Gene: LRIG3

121227
LIG3
leucine rich repeats and immunoglobulin like domains 3
protein-coding
12q14.1
Ensembl:ENSG00000139263 MIM:608870 Vega:OTTHUMG00000169940 UniprotKB:Q6UXM1
NC_000012.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.357e-2 (AD)  3.115e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CREB3L20.762
SHROOM40.752
CERS20.739
MTUS10.738
TRMT130.733
TJP20.733
TANC10.732
IQGAP10.728
ARHGAP170.728
LBR0.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSG1-0.365
PRSS56-0.33
KCNG1-0.329
HYAL3-0.326
CRH-0.32
CDH22-0.317
PHOSPHO1-0.316
HNF1A-0.314
GGN-0.309
KCNK12-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of LRIG3 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of LRIG3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LRIG3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of LRIG3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRIG3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRIG3 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LRIG3 mRNA21298039
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of LRIG3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRIG3 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRIG3 mRNA19770486
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of LRIG3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LRIG3 mRNA25047013
C006780bisphenol Abisphenol A results in decreased methylation of LRIG3 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of LRIG3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of LRIG3 mRNA25181051
D002104CadmiumCadmium results in decreased expression of LRIG3 mRNA24084258
D002994ClofibrateClofibrate results in decreased expression of LRIG3 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRIG3 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of LRIG3 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LRIG3 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of LRIG3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of LRIG3 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LRIG3 mRNA23914054
D004041Dietary FatsDietary Fats results in decreased expression of LRIG3 mRNA21852083
C014476diethyl maleatediethyl maleate results in decreased expression of LRIG3 mRNA21161181
D002117CalcitriolCalcitriol results in decreased expression of LRIG3 mRNA16002434
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of LRIG3 mRNA27638505
D004397FonofosFonofos results in increased methylation of LRIG3 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of LRIG3 mRNA20655997
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of LRIG3 mRNA22467014
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRIG3 mRNA25613284
D007854LeadLead affects the expression of LRIG3 mRNA28903495
C031895lead chromatelead chromate results in decreased expression of LRIG3 mRNA23584427
C045463leflunomideleflunomide results in increased expression of LRIG3 mRNA28988120
D008558MelphalanMelphalan results in decreased expression of LRIG3 mRNA22363485
D008694MethamphetamineMethamphetamine results in increased expression of LRIG3 mRNA19564919
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LRIG3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LRIG3 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of LRIG3 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LRIG3 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LRIG3 mRNA25729387
D010278ParathionParathion results in increased methylation of LRIG3 promoter22847954
C006253pirinixic acidpirinixic acid results in decreased expression of LRIG3 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LRIG3 mRNA22714537
D011794QuercetinQuercetin results in decreased expression of LRIG3 mRNA21632981
C031389resorcinolresorcinol results in decreased expression of LRIG3 mRNA22623647
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of LRIG3 mRNA22467014
C012568terbufosterbufos results in increased methylation of LRIG3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRIG3 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRIG3 mRNA21570461
D013752TetracyclineTetracycline results in increased expression of LRIG3 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRIG3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of LRIG3 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LRIG3 mRNA25729387
D014112ToxapheneToxaphene results in increased expression of LRIG3 mRNA23153324
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LRIG3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of LRIG3 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of LRIG3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of LRIG3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LRIG3 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LRIG3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0032474otolith morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21170350Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. (2010 Dec 7)Ostroff RMPLoS One
24998916Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. (2014 Apr 15)Lindstrom AKEur J Histochem
25813475LRIG1 is a prognostic biomarker in non-small cell lung cancer. (2015)Kvarnbrink SActa Oncol