Gene info: ID 121278

Gene: TPH2

GENE ID: 121278

Synonyms: ADHD7|NTPH

Description: tryptophan hydroxylase 2

Gene type: protein-coding

Location: 12q21.1

dbXrefs: Ensembl:ENSG00000139287 MIM:607478 Vega:OTTHUMG00000169677 UniprotKB:Q8IWU9

RefSeq: NG_008279.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.866e-1 (AD) 3.227e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNH1	0.78
PPM1E	0.778
TRPC5	0.773
PCDHAC2	0.772
ARHGAP20	0.77
SCN8A	0.769
KCNH5	0.766
DCC	0.765
CDH7	0.762
SLC4A8	0.761

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ACOX2	-0.502
STON2	-0.502
S100A1	-0.495
NFIA	-0.493
EYA2	-0.482
AKR1C3	-0.481
BBOX1	-0.469
CARHSP1	-0.466
NHSL1	-0.463
CYP2J2	-0.463

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB12095	Telotristat ethyl	Small Molecule	1033805-22-9	Approved\|Investigational	Target
DB00150	L-Tryptophan	Small Molecule	73-22-3	Approved\|Nutraceutical\|Withdrawn	Enzyme

ID	Drug Name	Action	PubMed
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TPH2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TPH2 mRNA	16483693
D000929	Antidepressive Agents, Tricyclic	"Antidepressive Agents, Tricyclic results in increased expression of TPH2 mRNA"	20374287
D001280	Atrazine	Atrazine results in decreased expression of TPH2 mRNA	25929836
D004958	Estradiol	[Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA	21382399
D004958	Estradiol	Estradiol results in increased expression of TPH2 mRNA	21382399
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of TPH2 mRNA	26186136
C006780	bisphenol A	bisphenol A results in increased expression of TPH2 mRNA	23567477
C006780	bisphenol A	bisphenol A results in decreased expression of TPH2 mRNA	25181051\|2614162
C006780	bisphenol A	bisphenol A results in increased expression of TPH2 mRNA	24066056
C006780	bisphenol A	bisphenol A results in increased expression of TPH2 protein	24066056
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TPH2 mRNA	22079614
D002110	Caffeine	Caffeine results in increased expression of TPH2 mRNA	22449533
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA]"	20230807
D004026	Dieldrin	Dieldrin results in decreased expression of TPH2 mRNA	23041725
D000431	Ethanol	Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein]	26747301
D000431	Ethanol	Ethanol results in decreased expression of TPH2 protein	26747301
D005473	Fluoxetine	TPH2 protein affects the susceptibility to Fluoxetine	16982082
D005473	Fluoxetine	Fluoxetine affects the expression of TPH2 mRNA	17321503
D005473	Fluoxetine	Fluoxetine results in increased expression of TPH2 mRNA	20374287
D005473	Fluoxetine	[Estradiol co-treated with Fluoxetine] results in increased expression of TPH2 mRNA	21382399
D005473	Fluoxetine	Fluoxetine affects the expression of TPH2 mRNA	17950541
D005473	Fluoxetine	Fluoxetine results in decreased expression of TPH2 mRNA	16982082\|2174092
D005473	Fluoxetine	Fluoxetine results in increased expression of TPH2 mRNA	11901216
D005473	Fluoxetine	TPH2 results in increased susceptibility to Fluoxetine	17950541
D005492	Folic Acid	Folic Acid results in increased expression of TPH2 mRNA	25006883
D012701	Serotonin	TPH2 protein affects the abundance of Serotonin	20722968
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of TPH2 mRNA	19840776
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of TPH2 protein	19840776
D008550	Melatonin	TPH2 protein affects the chemical synthesis of Melatonin	15281067
C548233	mephedrone	Ethanol promotes the reaction [mephedrone results in decreased expression of TPH2 protein]	26747301
C548233	mephedrone	mephedrone results in decreased expression of TPH2 protein	26747301
C548233	mephedrone	mephedrone results in decreased expression of TPH2 protein	25817894
D008694	Methamphetamine	TPH2 protein affects the susceptibility to Methamphetamine	20722968
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TPH2 mRNA	26011545
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA]"	20230807
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]	11901216
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA]"	20230807
C025589	ochratoxin A	ochratoxin A results in increased expression of TPH2 mRNA	27346841
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TPH2 mRNA	27001416
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TPH2 mRNA	24780913
D020280	Sertraline	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]	11901216
D020280	Sertraline	Sertraline results in increased activity of TPH2 protein	11901216
D020280	Sertraline	Sertraline results in increased expression of TPH2 mRNA	11901216
D020280	Sertraline	Sertraline results in increased expression of TPH2 protein	11901216
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TPH2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004510	tryptophan 5-monooxygenase activity	-	IEA	-
GO:0005506	iron ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007623	circadian rhythm	-	IEA	-
GO:0009072	aromatic amino acid family metabolic process	-	IEA	-
GO:0014823	response to activity	-	IEA	-
GO:0031667	response to nutrient levels	-	IEA	-
GO:0042427	serotonin biosynthetic process	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051592	response to calcium ion	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0071285	cellular response to lithium ion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0043005	neuron projection	-	IEA	-

KEGG ID	KEGG Term
hsa00380	Tryptophan metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-209776	Amine-derived hormones	TAS
R-HSA-209931	Serotonin and melatonin biosynthesis	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16759340	Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. (2006 Mar)	Dahl JP	Addict Biol
19734157	Clinical and genetic risk factors for suicide under the influence of alcohol in a Polish sample. (2009 Sep-Oct)	Fudalej S	Alcohol Alcohol
22925276	Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. (2012 Nov)	Nielsen DA	Genes Brain Behav
18826444	Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. (2008 Nov)	Lee BT	Genes Brain Behav
18405071	Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (2008 Jan)	Mokrovic G	Coll Antropol
23995203	Tryptophan hydroxylase 2 (TPH 2) single nucleotide polymorphisms, suicide, and alcohol-related suicide. (2013 Sep)	Zupanc T	Psychiatr Danub
19742166	Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. (2009 Jul)	Drago A	Int J Environ Res Public Health
19170664	Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. (2009 Apr)	Wojnar M	Alcohol Clin Exp Res
26232682	Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms. (2015 Sep 14)	Plemenitas A	Neurosci Lett
21797889	The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. (2012 Jan)	Kristjansson SD	Alcohol Clin Exp Res
24067926	Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. (2014 Feb)	Sachs BD	Neuropharmacology
21182896	TPH2 polymorphisms and alcohol-related suicide. (2011 Feb 18)	Zupanc T	Neurosci Lett
26954509	Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides. (2016 Jul 2)	Bach H	Arch Suicide Res
26073764	Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine. (2015 Dec 15)	Vasudeva RK	Behav Brain Res
21621273	Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. (2011 Nov 30)	Wrzosek M	Psychiatry Res
17251907	SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. (2007 Aug)	Zill P	Neuropsychopharmacology
17986837	The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. (2007)	Reuter M	Neuropsychobiology
26013962	Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. (2015 Dec)	Havranek MM	Neuropsychopharmacology
19361870	TPH2 gene variants and anxiety during alcohol detoxification outcome. (2009 May 15)	Serretti A	Psychiatry Res