Gene info: ID 1213

Gene: CLTC

GENE ID: 1213

Synonyms: CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56

Description: clathrin heavy chain

Gene type: protein-coding

Location: 17q23.1

dbXrefs: Ensembl:ENSG00000141367 MIM:118955 Vega:OTTHUMG00000134279 UniprotKB:Q00610

RefSeq: NG_047043.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.139e-1 (AD) 6.028e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04497094	chr17:57741573	CLTC	Gene body	2.474e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UBQLN1	0.981
NAPG	0.978
CAND1	0.976
NDFIP1	0.976
PLEKHB2	0.976
VPS35	0.975
ATP2A2	0.975
PAFAH1B1	0.975
ATXN7L3B	0.975
PGK1	0.974

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.64
OR4F29	-0.592
CSAG1	-0.408
HEY2	-0.374
RAI14	-0.37
MTRNR2L6	-0.357
MYL3	-0.352
MTRNR2L10	-0.349
TFPI2	-0.345
SH2D1A	-0.342

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of CLTC protein"	21673325
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CLTC mRNA"	21346803
C021296	2-ethoxyethanol	2-ethoxyethanol results in increased expression of CLTC mRNA	19643169
C498826	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	[arsenic trioxide co-treated with 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide] affects the expression of CLTC mRNA	28786057
D000082	Acetaminophen	Acetaminophen results in decreased expression of CLTC mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of CLTC mRNA	17562736
D020106	Acrylamide	Acrylamide binds to and affects the metabolism of CLTC protein	17698512
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CLTC gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CLTC mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CLTC mRNA	24449571
C006632	arsenic trioxide	[arsenic trioxide co-treated with 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide] affects the expression of CLTC mRNA	28786057
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CLTC mRNA	20458559
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CLTC protein	25419056
D001280	Atrazine	Atrazine results in decreased expression of CLTC mRNA	25929836
D001554	Benzene	Benzene results in increased expression of CLTC mRNA	15929907\|1916216
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CLTC mRNA	22300585
C006780	bisphenol A	bisphenol A results in increased expression of CLTC mRNA	25181051
D001761	Bleomycin	Bleomycin results in decreased expression of CLTC protein	25933445
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CLTC mRNA	18804290
D019256	Cadmium Chloride	CLTC mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]	25046863
D002220	Carbamazepine	Carbamazepine affects the expression of CLTC mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CLTC mRNA	27339419
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLTC gene	20938992
C014347	decitabine	decitabine affects the methylation of CLTC gene	17630775
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CLTC mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of CLTC mRNA	25450742
D004041	Dietary Fats	Dietary Fats results in increased expression of CLTC mRNA	19030233\|2501614
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLTC mRNA]	19030233
C071192	entacapone	entacapone binds to CLTC protein	19783845
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CLTC protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CLTC mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CLTC mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLTC mRNA	17942748
D005472	Fluorouracil	CLTC protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CLTC mRNA]	15016801
D005485	Flutamide	Flutamide results in increased expression of CLTC mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLTC gene	20938992
C056933	fumonisin B1	fumonisin B1 results in increased expression of CLTC mRNA	16221962
D005839	Gentamicins	Gentamicins results in increased expression of CLTC mRNA	22061828
C071834	glycidamide	glycidamide results in increased expression of CLTC mRNA	17822822
C051890	irinotecan	CLTC protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]	18927307
C051890	irinotecan	irinotecan analog results in decreased expression of CLTC mRNA	18927307
C544151	jinfukang	jinfukang results in decreased expression of CLTC mRNA	27392435
D007657	Ketone Bodies	Ketone Bodies results in increased expression of CLTC mRNA	16807920
C008261	lead acetate	lead acetate results in decreased expression of CLTC mRNA	21891863
D001556	Lindane	Lindane results in increased expression of CLTC mRNA	18804290
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CLTC mRNA	21641980
D008628	Mercury	Mercury results in decreased expression of CLTC mRNA	16823088
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLTC gene	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of CLTC mRNA	19643169
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CLTC mRNA	18804290
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]	17220478
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CLTC mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of CLTC mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of CLTC mRNA	17616710
D010100	Oxygen	Oxygen deficiency results in increased expression of CLTC mRNA	24205000
D010634	Phenobarbital	Phenobarbital results in decreased expression of CLTC mRNA	16940010
D010936	Plant Extracts	Plant Extracts results in increased expression of CLTC mRNA	23557933
D011748	Pyrogallol	Pyrogallol results in increased expression of CLTC mRNA	20362636
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of CLTC mRNA]	19030233
C010327	salinomycin	salinomycin results in decreased expression of CLTC mRNA	19682730
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of CLTC protein	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of CLTC protein	19072884
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CLTC protein	27548804
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CLTC mRNA	21641980
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in decreased expression of CLTC mRNA"	26680231
D013629	Tamoxifen	Tamoxifen affects the expression of CLTC mRNA	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLTC mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CLTC gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CLTC mRNA	17942748\|2821309
D019284	Thapsigargin	Thapsigargin results in increased expression of CLTC protein	24648495
C066340	tolcapone	tolcapone binds to CLTC protein	19783845
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of CLTC mRNA	25855008
D014635	Valproic Acid	Valproic Acid affects the expression of CLTC mRNA	25979313
C025643	vinclozolin	vinclozolin results in decreased expression of CLTC mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22681889
GO:0003725	double-stranded RNA binding	-	IDA	21266579
GO:0005198	structural molecule activity	-	NAS	1765375
GO:0005515	protein binding	-	IPI	12429846 14743216 16137687 16902405 17353931 18548008 19478182 19536138 19798056 25107275 25241761 26005850 26496610
GO:0019901	protein kinase binding	-	ISS	-
GO:0030506	ankyrin binding	-	IBA	21873635
GO:0031072	heat shock protein binding	-	IBA	21873635
GO:0032051	clathrin light chain binding	-	IBA	21873635
GO:0032051	clathrin light chain binding	-	IPI	4066749
GO:0042277	peptide binding	-	IBA	21873635
GO:0042802	identical protein binding	-	IBA	21873635
GO:0050750	low-density lipoprotein particle receptor binding	-	IBA	21873635
GO:0050750	low-density lipoprotein particle receptor binding	-	IPI	26005850
GO:0097718	disordered domain specific binding	-	IBA	21873635
GO:0097718	disordered domain specific binding	-	IPI	11756460
GO:1990381	ubiquitin-specific protease binding	-	IPI	26756164
GO:1990763	arrestin family protein binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000278	mitotic cell cycle	-	IBA	21873635
GO:0000278	mitotic cell cycle	-	IMP	15858577
GO:0001649	osteoblast differentiation	-	HDA	16210410
GO:0006886	intracellular protein transport	-	NAS	1765375
GO:0006898	receptor-mediated endocytosis	-	IBA	21873635
GO:0006898	receptor-mediated endocytosis	-	IMP	15858577
GO:0006914	autophagy	-	IEA	-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	-
GO:0031623	receptor internalization	-	IMP	14985334
GO:0032802	low-density lipoprotein particle receptor catabolic process	-	TAS	-
GO:0033572	transferrin transport	-	IBA	21873635
GO:0033572	transferrin transport	-	IMP	14985334
GO:0034383	low-density lipoprotein particle clearance	-	TAS	-
GO:0042147	retrograde transport, endosome to Golgi	-	IMP	20065094
GO:0045056	transcytosis	-	IMP	26005850
GO:0048268	clathrin coat assembly	-	IBA	21873635
GO:0048268	clathrin coat assembly	-	IMP	11756460
GO:0051301	cell division	-	IEA	-
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	-
GO:0060236	regulation of mitotic spindle organization	-	IBA	21873635
GO:0060236	regulation of mitotic spindle organization	-	IMP	21297582
GO:0061024	membrane organization	-	TAS	-
GO:0072583	clathrin-dependent endocytosis	-	IMP	26005850
GO:1900126	negative regulation of hyaluronan biosynthetic process	-	IDA	24251095
GO:1900126	negative regulation of hyaluronan biosynthetic process	-	IMP	23509262
GO:1903077	negative regulation of protein localization to plasma membrane	-	IMP	19581412

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005764	lysosome	-	IDA	-
GO:0005768	endosome	-	IDA	-
GO:0005819	spindle	-	IBA	21873635
GO:0005819	spindle	-	IDA	15858577
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0016020	membrane	-	HDA	16210410 19946888
GO:0030118	clathrin coat	-	IMP	11756460
GO:0030118	clathrin coat	-	NAS	1765375
GO:0030130	clathrin coat of trans-Golgi network vesicle	-	IEA	-
GO:0030132	clathrin coat of coated pit	-	IEA	-
GO:0030136	clathrin-coated vesicle	-	IDA	19478182
GO:0030315	T-tubule	-	IBA	21873635
GO:0030669	clathrin-coated endocytic vesicle membrane	-	TAS	-
GO:0032588	trans-Golgi network membrane	-	TAS	-
GO:0032991	protein-containing complex	-	IDA	21266579
GO:0036020	endolysosome membrane	-	TAS	-
GO:0042470	melanosome	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0045334	clathrin-coated endocytic vesicle	-	IBA	21873635
GO:0045334	clathrin-coated endocytic vesicle	-	NAS	25898166
GO:0070062	extracellular exosome	-	HDA	12519789 19056867 19199708 20458337 21362503 23533145
GO:0071439	clathrin complex	-	IBA	21873635
GO:0071439	clathrin complex	-	IDA	4066749
GO:0072686	mitotic spindle	-	IDA	-
GO:1903561	extracellular vesicle	-	HDA	24769233
GO:1990498	mitotic spindle microtubule	-	IDA	21297582

KEGG ID	KEGG Term
hsa04142	Lysosome
hsa04144	Endocytosis
hsa05016	Huntington's disease
hsa05100	Bacterial invasion of epithelial cells

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-157858	Gap junction trafficking and regulation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	TAS
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-177504	Retrograde neurotrophin signalling	IEA
R-HSA-177504	Retrograde neurotrophin signalling	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	IEA
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-190828	Gap junction trafficking	TAS
R-HSA-190873	Gap junction degradation	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-196025	Formation of annular gap junctions	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199992	trans-Golgi Network Vesicle Budding	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-373760	L1CAM interactions	TAS
R-HSA-373760	L1CAM interactions	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-421837	Clathrin derived vesicle budding	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-432720	Lysosome Vesicle Biogenesis	TAS
R-HSA-432722	Golgi Associated Vesicle Biogenesis	TAS
R-HSA-437239	Recycling pathway of L1	TAS
R-HSA-437239	Recycling pathway of L1	IEA
R-HSA-5099900	WNT5A-dependent internalization of FZD4	TAS
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS
R-HSA-8866427	VLDLR internalisation and degradation	TAS
R-HSA-8964038	LDL clearance	TAS
R-HSA-8964043	Plasma lipoprotein clearance	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18242762	EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (2008 Aug)	Shinmura K	Lung Cancer
28418321	S100A10 identified in a genome-wide gene x cannabis dependence interaction analysis of risky sexual behaviours. (2017 Jun)	Polimanti R	J Psychiatry Neurosci