Gene: NEDD1

121441
GCP-WD|TUBGCP7
neural precursor cell expressed, developmentally down-regulated 1
protein-coding
12q23.1
Ensembl:ENSG00000139350 MIM:600372 Vega:OTTHUMG00000170604 UniprotKB:Q8NHV4
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.530e-1 (AD)  1.125e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs249571chr12:96927433 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BNIP20.879
REST0.877
RP20.858
IRAK40.846
CMTM60.843
TRAM10.841
SMAD50.84
ZNF2170.838
EPS80.838
MDFIC0.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.607
ADRA1D-0.591
PIP5KL1-0.583
KCNB2-0.57
LRFN2-0.561
HAS1-0.558
BCL11A-0.557
CDH22-0.553
INPP5J-0.55
DLK2-0.55

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NEDD1 mRNA"21354444
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NEDD1 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NEDD1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NEDD1 mRNA23630614
C006632arsenic trioxidearsenic trioxide results in increased expression of NEDD1 mRNA20458559
D001280AtrazineAtrazine results in increased expression of NEDD1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEDD1 mRNA21632981
C006780bisphenol Abisphenol A affects the expression of NEDD1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NEDD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NEDD1 gene28505145
D000069286BortezomibBortezomib results in increased expression of NEDD1 mRNA20977926
D002220CarbamazepineCarbamazepine affects the expression of NEDD1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NEDD1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD1 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of NEDD1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of NEDD1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of NEDD1 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NEDD1 mRNA23914054
C000944dicrotophosdicrotophos results in decreased expression of NEDD1 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NEDD1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NEDD1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NEDD1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of NEDD1 mRNA23649840
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NEDD1 mRNA17183730
C544151jinfukangjinfukang results in decreased expression of NEDD1 mRNA27392435
D007840LatexLatex analog results in increased expression of NEDD1 mRNA24768652
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NEDD1 mRNA23649840
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NEDD1 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of NEDD1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NEDD1 mRNA22079256
C045362prochlorazprochloraz results in increased expression of NEDD1 mRNA21470553
D011441PropylthiouracilPropylthiouracil results in increased expression of NEDD1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NEDD1 mRNA27029645
D013629TamoxifenTamoxifen affects the expression of NEDD1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEDD1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD1 mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NEDD1 mRNA28973375
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NEDD1 mRNA25729387
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NEDD1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of NEDD1 gene29154799
C111237vorinostatvorinostat results in increased expression of NEDD1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19369198  27137183  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0051301cell division-IEA-  
GO:0071539protein localization to centrosome-IBA21873635  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000242pericentriolar material-IBA21873635  
GO:0000922spindle pole-IBA21873635  
GO:0005813centrosome-IDA21399614  27137183  
GO:0005814centriole-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0036064ciliary basal body-IBA21873635  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal