Gene: FGD4

121512
CMT4H|FRABP|ZFYVE6
FYVE, RhoGEF and PH domain containing 4
protein-coding
12p11.21
Ensembl:ENSG00000139132 MIM:611104 Vega:OTTHUMG00000137374 UniprotKB:Q96M96
NG_008626.2
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.833e-1 (AD)  2.547e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRPS10.882
MTM10.869
FERMT20.849
TEAD10.847
PIK3C2A0.841
ITPR20.839
CPNE30.836
BMPR1B0.836
CDC14A0.834
SASH10.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VGF-0.424
ABCC12-0.41
ADRA1D-0.4
RHO-0.392
MCHR1-0.388
OR4F5-0.384
LAMB3-0.381
RTP1-0.377
GSG1-0.373
GPR68-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FGD4 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
C0127962-butenal2-butenal results in increased expression of FGD4 mRNA20471460
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FGD4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FGD4 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of FGD4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FGD4 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of FGD4 mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of FGD4 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGD4 mRNA16483693
D001151ArsenicArsenic affects the methylation of FGD4 gene25304211
C547126AZM551248AZM551248 results in decreased expression of FGD4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGD4 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGD4 mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FGD4 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FGD4 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of FGD4 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGD4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of FGD4 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of FGD4 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FGD4 mRNA12734012
C018021cobaltous chloridecobaltous chloride results in decreased expression of FGD4 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of FGD4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FGD4 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of FGD4 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGD4 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of FGD4 mRNA21603599
D002117CalcitriolCalcitriol results in increased expression of FGD4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of FGD4 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FGD4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGD4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGD4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGD4 mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of FGD4 mRNA20655997
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FGD4 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of FGD4 mRNA27392435
C045463leflunomideleflunomide results in increased expression of FGD4 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FGD4 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGD4 mRNA26378955
D008558MelphalanMelphalan results in decreased expression of FGD4 mRNA22363485
D008727MethotrexateMethotrexate affects the expression of FGD4 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FGD4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of FGD4 promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FGD4 mRNA"25554681
D009532NickelNickel results in decreased expression of FGD4 mRNA23195993
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGD4 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in decreased expression of FGD4 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FGD4 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of FGD4 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FGD4 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of FGD4 mRNA21297082
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FGD4 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of FGD4 mRNA21795739
C059514resveratrolresveratrol results in increased expression of FGD4 protein18089832
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FGD4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FGD4 mRNA23221170
D012969Sodium FluorideSodium Fluoride results in increased expression of FGD4 mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FGD4 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FGD4 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of FGD4 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of FGD4 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of FGD4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGD4 mRNA26238291
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGD4 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FGD4 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGD4 mRNA17942748
D014212TretinoinTretinoin results in decreased expression of FGD4 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of FGD4 mRNA26705709
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of FGD4 mRNA29024780
D014520UrethaneUrethane results in increased expression of FGD4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGD4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FGD4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FGD4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of FGD4 gene29154799
D014638VanadatesVanadates results in decreased expression of FGD4 mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of FGD4 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005085guanyl-nucleotide exchange factor activity-ISS-  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0031267small GTPase binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008360regulation of cell shape-ISS-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043087regulation of GTPase activity-ISS-  
GO:0046847filopodium assembly-ISS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0030027lamellipodium-ISS-  
GO:0030175filopodium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22295116Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. (2012)Pei YFPLoS One
22430805Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study. (2012 Mar)Langevin SMEpigenetics