Gene info: ID 122416

Gene: ANKRD9

GENE ID: 122416

Synonyms: -

Description: ankyrin repeat domain 9

Gene type: protein-coding

Location: 14q32.31

dbXrefs: Ensembl:ENSG00000156381 Vega:OTTHUMG00000171777 UniprotKB:Q96BM1

RefSeq: NC_000014.9

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.787e-1 (AD) 6.369e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM160	0.859
ZFPM1	0.853
ZNF771	0.818
TPGS1	0.805
PCSK1N	0.797
TRAPPC5	0.793
CCDC85B	0.789
PRR7	0.789
C4orf48	0.788
ZNF579	0.775

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.462
OR4F29	-0.414
MYF6	-0.39
ZNF300	-0.357
CTNNA3	-0.352
ZFP57	-0.337
CNTF	-0.335
RNF125	-0.332
CENPK	-0.33
DTHD1	-0.328

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ANKRD9 mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD9 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of ANKRD9 mRNA	28959563
D001507	Beclomethasone	Beclomethasone results in increased expression of ANKRD9 mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANKRD9 mRNA	21839799
C006780	bisphenol A	bisphenol A results in increased expression of ANKRD9 mRNA	27685785
D000069286	Bortezomib	Bortezomib results in increased expression of ANKRD9 mRNA	20977926
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ANKRD9 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of ANKRD9 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of ANKRD9 mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ANKRD9 mRNA	24317228
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of ANKRD9 mRNA	23656968
D002945	Cisplatin	Cisplatin results in increased expression of ANKRD9 mRNA	27594783
C000944	dicrotophos	dicrotophos results in decreased expression of ANKRD9 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of ANKRD9 mRNA	18042831
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of ANKRD9 mRNA	26846883
C492448	ICG 001	ICG 001 results in increased expression of ANKRD9 mRNA	26191083
C045463	leflunomide	leflunomide results in increased expression of ANKRD9 mRNA	28988120
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ANKRD9 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANKRD9 mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of ANKRD9 mRNA	24810058
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of ANKRD9 mRNA	24128854
D009966	Orphenadrine	Orphenadrine affects the expression of ANKRD9 mRNA	23665939
C005290	oxybenzone	oxybenzone results in decreased expression of ANKRD9 mRNA	22721600
D010100	Oxygen	Oxygen deficiency results in decreased expression of ANKRD9 mRNA	26516004
D000073878	Palm Oil	Palm Oil results in decreased expression of ANKRD9 mRNA	18042831
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ANKRD9 mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD9 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ANKRD9 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of ANKRD9 mRNA	23811191
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ANKRD9 mRNA	24780913
D014284	Triiodothyronine	Triiodothyronine results in decreased expression of ANKRD9 mRNA	19788857
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANKRD9 mRNA	24680724
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of ANKRD9 mRNA	28973375
D013849	Thimerosal	Thimerosal results in decreased expression of ANKRD9 mRNA	27188386
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ANKRD9 mRNA"	26743178
D014635	Valproic Acid	Valproic Acid affects the expression of ANKRD9 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of ANKRD9 gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0044325	ion channel binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0043687	post-translational protein modification	-	TAS	-
GO:0050808	synapse organization	-	IBA	21873635
GO:0072659	protein localization to plasma membrane	-	IBA	21873635
GO:0099612	protein localization to axon	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0014704	intercalated disc	-	IBA	21873635
GO:0016020	membrane	-	IBA	21873635
GO:0033268	node of Ranvier	-	IBA	21873635
GO:0033270	paranode region of axon	-	IBA	21873635
GO:0043194	axon initial segment	-	IBA	21873635
GO:0045202	synapse	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8951664	Neddylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29618728	Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)	Miyake K	Sci Rep