Gene: PLD4

122618
C14orf175
phospholipase D family member 4
protein-coding
14q32.33
Ensembl:ENSG00000166428 Vega:OTTHUMG00000144167 UniprotKB:Q96BZ4
NC_000014.9
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.225e-1 (AD)  2.754e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10083490chr14:104936081 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27394566chr14:105391635PLD43.470e-10Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SELPLG0.834
FOLR20.828
P2RY120.822
TMEM1190.818
BLNK0.813
CSF1R0.81
SUSD30.803
RGS100.801
LY860.799
C30.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEX38-0.228
MISP-0.228
CRLF2-0.228
CRYBB2-0.228
PRB3-0.219
SPAG11A-0.218
KISS1-0.217
UTF1-0.213
PARD6B-0.213
BAAT-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLD4 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of PLD4 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of PLD4 mRNA28959563
D001372Aza CompoundsAza Compounds results in decreased expression of PLD4 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of PLD4 mRNA20521778
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLD4 mRNA21569818
D004958EstradiolEstradiol results in increased expression of PLD4 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PLD4 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of PLD4 mRNA23125180
D003976DiazinonDiazinon results in decreased methylation of PLD4 gene22964155
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PLD4 mRNA25380136
D004397FonofosFonofos results in decreased methylation of PLD4 promoter22847954
D007211IndolesIndoles results in decreased expression of PLD4 mRNA20521778
D007211IndolesIndoles results in increased expression of PLD4 mRNA20521778
D007501IronIron deficiency results in decreased expression of PLD4 mRNA20368581
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLD4 mRNA23086925
D007649KetamineKetamine results in increased expression of PLD4 mRNA20080153
D048628KetolidesKetolides analog results in increased expression of PLD4 mRNA24967691
C008261lead acetatelead acetate results in increased expression of PLD4 mRNA21829687
D008701MethapyrileneMethapyrilene results in increased expression of PLD4 mRNA22484513
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PLD4 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PLD4 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLD4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLD4 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLD4 mRNA25729387
D010278ParathionParathion results in decreased methylation of PLD4 promoter22847954
D011441PropylthiouracilPropylthiouracil results in increased expression of PLD4 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in increased expression of PLD4 mRNA18175754
D012999SomanSoman results in increased expression of PLD4 mRNA19281266
C016766sulforafansulforafan results in decreased expression of PLD4 mRNA26833863
C012568terbufosterbufos results in decreased methylation of PLD4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLD4 mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLD4 mRNA26290441
D013853ThioacetamideThioacetamide results in decreased expression of PLD4 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PLD4 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLD4 mRNA25729387
D014635Valproic AcidValproic Acid results in increased methylation of PLD4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PLD4 mRNA17292431
C029297vinylidene chloridevinylidene chloride results in increased expression of PLD4 mRNA26682919
D014807Vitamin DVitamin D affects the expression of PLD4 mRNA20368581

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-TAS-  
GO:0004630phospholipase D activity-IEA-  
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IBA21873635  
GO:0006909phagocytosis-IBA21873635  
GO:0016042lipid catabolic process-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0032588trans-Golgi network membrane-IBA21873635  
GO:0045335phagocytic vesicle-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1483148Synthesis of PGIEA
R-HSA-1483206Glycerophospholipid biosynthesisIEA
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1483257Phospholipid metabolismIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029485Role of phospholipids in phagocytosisTAS
R-HSA-556833Metabolism of lipidsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One