Gene info: ID 1230

Gene: CCR1

GENE ID: 1230

Synonyms: CD191|CKR-1|CKR1|CMKBR1|HM145|MIP1aR|SCYAR1

Description: C-C motif chemokine receptor 1

Gene type: protein-coding

Location: 3p21.31

dbXrefs: Ensembl:ENSG00000163823 MIM:601159 Vega:OTTHUMG00000133451 UniprotKB:P32246

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.885e-1 (AD) 4.219e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SASH3	0.952
LAIR1	0.948
CYTH4	0.944
PIK3AP1	0.937
CD300A	0.93
SAMSN1	0.925
ABI3	0.923
HCK	0.922
LRRC25	0.922
SLC7A7	0.921

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.456
KCNIP3	-0.451
TMEM179	-0.437
TMEM191C	-0.423
MAGIX	-0.414
WNT7A	-0.414
ZSCAN1	-0.412
DLK2	-0.401
KCNK4	-0.398
MARCH4	-0.396

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C063609	1,2-dimethyl-4-nitrobenzene	"1,2-dimethyl-4-nitrobenzene results in decreased expression of CCR1 mRNA"	19784758
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCR1 mRNA"	27291303
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of CCR1 mRNA"	20638727
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCR1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA	12419474
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCR1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of CCR1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of CCR1 mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCR1 mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in increased expression of CCR1 mRNA	19784758
D020106	Acrylamide	Acrylamide results in increased expression of CCR1 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCR1 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of CCR1 mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CCR1 mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of CCR1 protein	24675094
D001151	Arsenic	[Arsenic co-treated with Fluorides] results in decreased expression of CCR1 mRNA	19962721
D001151	Arsenic	Arsenic results in decreased expression of CCR1 mRNA	19962721
D001151	Arsenic	Arsenic results in decreased expression of CCR1 mRNA	19654921
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CCR1 mRNA	15894607
C015001	arsenite	arsenite results in decreased expression of CCR1 mRNA	18191166
C547126	AZM551248	AZM551248 results in increased expression of CCR1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of CCR1 gene	25435355
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of CCR1 mRNA	15912405
D001966	Bromine	Bromine results in increased expression of CCR1 mRNA	18790026\|2139129
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CCR1 mRNA	12160620
C040048	caffeic acid	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA	16806235
D002235	Carbofuran	Carbofuran results in increased expression of CCR1 mRNA	20211217
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CCR1 mRNA	23288052
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CCR1 mRNA	19784758
D002392	Catechin	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA	16806235
D002713	Chlorine	Chlorine results in increased expression of CCR1 mRNA	22533443
D002794	Choline	[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCR1 mRNA	23439872
C000488	cladosporin	cladosporin results in increased expression of CCR1 mRNA	19818335
D003436	Croton Oil	Croton Oil results in increased expression of CCR1 mRNA	19647056
C038459	curdlan	curdlan affects the expression of CCR1 mRNA	19904525
D016572	Cyclosporine	Cyclosporine results in decreased expression of CCR1 mRNA	27989131
D017373	Cyproterone Acetate	[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein	10770211
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCR1 mRNA	22968694
D002945	Cisplatin	Cisplatin results in increased expression of CCR1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of CCR1 mRNA	15814532
D002945	Cisplatin	pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR1 mRNA]	15814532
D004008	Diclofenac	Diclofenac results in increased expression of CCR1 mRNA	26934552
C027118	didecyldimethylammonium	didecyldimethylammonium results in increased expression of CCR1 mRNA	19762220
D004052	Diethylnitrosamine	CCR1 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 mRNA]	16284949
D004052	Diethylnitrosamine	CCR1 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 protein]	16284949
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCR1 mRNA	19647056
D004317	Doxorubicin	Doxorubicin results in increased expression of CCR1 mRNA	20211217\|2718193
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CCR1 mRNA]	27181935
C046855	epostane	epostane promotes the reaction [Dinoprost results in increased expression of CCR1 mRNA]	21505051
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein	10770211
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CCR1 mRNA	15885639
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CCR1 mRNA	15212814
D015025	Zearalenone	Zearalenone results in increased expression of CCR1 mRNA	27757495
D005459	Fluorides	[Arsenic co-treated with Fluorides] results in decreased expression of CCR1 mRNA	19962721
D005459	Fluorides	Fluorides results in decreased expression of CCR1 mRNA	19962721
D005492	Folic Acid	[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCR1 mRNA	23439872
C056933	fumonisin B1	fumonisin B1 results in increased expression of CCR1 mRNA	27757495
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CCR1 mRNA]	27181935
C039281	furan	furan results in increased expression of CCR1 mRNA	27387713
D005839	Gentamicins	Gentamicins results in increased expression of CCR1 mRNA	22061828
D017313	Fenretinide	Fenretinide results in increased expression of CCR1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CCR1 mRNA	12419474
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR1 mRNA	25613284
C051890	irinotecan	irinotecan metabolite results in increased expression of CCR1 mRNA	15956246
C051890	irinotecan	irinotecan results in increased expression of CCR1 mRNA	15956246
D007545	Isoproterenol	Isoproterenol results in increased expression of CCR1 mRNA	20211217
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCR1 mRNA	21889194\|2194939
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCR1 mRNA	25982114
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCR1 mRNA	26111115
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCR1 protein	26111115
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCR1 mRNA	21641980
D008627	Mercuric Chloride	CCR1 protein results in increased susceptibility to Mercuric Chloride	12834626
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CCR1 mRNA	12834626
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CCR1 protein	12834626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CCR1 mRNA	23649840
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]	16321392
C523799	MRK 003	CCR1 results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of CCR1 mRNA	15674843\|1895507
D009151	Mustard Gas	Mustard Gas results in increased expression of CCR1 mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CCR1 mRNA"	23845593
C015380	neoechinulin	neoechinulin results in decreased expression of CCR1 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in increased expression of CCR1 mRNA	19818335
D009532	Nickel	Nickel results in increased expression of CCR1 mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of CCR1 mRNA	19167457
C029938	nickel sulfate	nickel sulfate affects the expression of CCR1 mRNA	18202158
D009578	Nitrobenzenes	Nitrobenzenes analog results in decreased expression of CCR1 mRNA	19784758
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR1 mRNA"	19013360
C024713	n-tetradecane	n-tetradecane results in decreased expression of CCR1 protein	17337753
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CCR1 mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of CCR1 mRNA	19647056
D010100	Oxygen	HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CCR1 mRNA]	20880076
D010100	Oxygen	Oxygen deficiency results in increased expression of CCR1 mRNA	20880076
D010126	Ozone	Ozone results in increased expression of CCR1 protein	27679563
C006253	pirinixic acid	pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR1 mRNA]	15814532
C006253	pirinixic acid	pirinixic acid results in decreased expression of CCR1 mRNA	16985257
C006253	pirinixic acid	pirinixic acid results in increased expression of CCR1 mRNA	20813756
D059808	Polyphenols	Polyphenols results in decreased expression of CCR1 mRNA	16293270
D011374	Progesterone	Progesterone results in increased expression of CCR1 mRNA	21770760
D015237	Dinoprost	Dinoprost results in increased expression of CCR1 mRNA	21505051
D015237	Dinoprost	epostane promotes the reaction [Dinoprost results in increased expression of CCR1 mRNA]	21505051
C059514	resveratrol	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA	16806235
D012524	Sarin	Sarin results in increased expression of CCR1 mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CCR1 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CCR1 mRNA	19073995\|2322117
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]	16321392
D019821	Simvastatin	Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]	16321392
D019821	Simvastatin	Simvastatin results in decreased expression of CCR1 mRNA	16414398
C016104	sodium bichromate	sodium bichromate results in decreased expression of CCR1 mRNA	17685462
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of CCR1 mRNA	19818335
D020058	Styrene	Styrene results in decreased expression of CCR1 mRNA	15212811
D020058	Styrene	Styrene results in decreased expression of CCR1 protein	15212811
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCR1 mRNA	21641980
C061133	tamibarotene	tamibarotene results in increased expression of CCR1 mRNA	15498508
C004648	testosterone enanthate	testosterone enanthate affects the expression of CCR1 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCR1 mRNA	27913140
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CCR1 mRNA	27913140
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCR1 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CCR1 mRNA	27913140
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of CCR1 mRNA	19784758
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CCR1 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CCR1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CCR1 mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of CCR1 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of CCR1 mRNA	15498508\|1589460
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CCR1 mRNA	16141432
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCR1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of CCR1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of CCR1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CCR1 gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CCR1 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004435	phosphatidylinositol phospholipase C activity	-	IDA	10734056
GO:0004950	chemokine receptor activity	-	IDA	10660125
GO:0005515	protein binding	-	IPI	8699119 15001559 15474493
GO:0016493	C-C chemokine receptor activity	-	IBA	21873635
GO:0016493	C-C chemokine receptor activity	-	IDA	10734056
GO:0019956	chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IPI	7545673 8699119 10660125 15764707
GO:0035717	chemokine (C-C motif) ligand 7 binding	-	IBA	21873635
GO:0035717	chemokine (C-C motif) ligand 7 binding	-	IPI	7545673 10660125
GO:0071791	chemokine (C-C motif) ligand 5 binding	-	IBA	21873635
GO:0071791	chemokine (C-C motif) ligand 5 binding	-	IPI	7545673 8699119 10660125 10734056

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002407	dendritic cell chemotaxis	-	TAS	16621978
GO:0006816	calcium ion transport	-	IDA	10734056
GO:0006874	cellular calcium ion homeostasis	-	IDA	10734056
GO:0006887	exocytosis	-	IDA	10734056
GO:0006935	chemotaxis	-	IBA	21873635
GO:0006935	chemotaxis	-	NAS	15474493
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	IBA	21873635
GO:0006955	immune response	-	IDA	10734056
GO:0007155	cell adhesion	-	TAS	10910894
GO:0007166	cell surface receptor signaling pathway	-	TAS	10770925
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	7505609
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IDA	10734056
GO:0007267	cell-cell signaling	-	IDA	10734056
GO:0009611	response to wounding	-	TAS	7505609
GO:0010629	negative regulation of gene expression	-	IMP	21403648
GO:0019221	cytokine-mediated signaling pathway	-	NAS	15474493
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0019722	calcium-mediated signaling	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	IMP	24056371
GO:0030502	negative regulation of bone mineralization	-	IMP	21403648
GO:0045672	positive regulation of osteoclast differentiation	-	IMP	21403648
GO:0051928	positive regulation of calcium ion transport	-	IDA	15764707
GO:0060326	cell chemotaxis	-	IBA	21873635
GO:0070098	chemokine-mediated signaling pathway	-	IDA	21403648
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	21403648
GO:0090026	positive regulation of monocyte chemotaxis	-	IDA	18587271

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	10660125 15474493 18587271
GO:0005886	plasma membrane	-	IMP	15001559
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	7505609
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0009897	external side of plasma membrane	-	IDA	10706735

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-380108	Chemokine receptors bind chemokines	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20217071	Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (2010 Apr)	Pan F	Immunogenetics
23895590	Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells. (2013 Dec)	Parlet CP	Alcohol Clin Exp Res
23217400	CCR1 and CCR5 expression on inflammatory cells is related to cigarette smoking and chronic obstructive pulmonary disease severity. (2012 Dec)	Wang F	Chin Med J (Engl)