Gene info: ID 1232

Gene: CCR3

GENE ID: 1232

Synonyms: CC-CKR-3|CD193|CKR3|CMKBR3

Description: C-C motif chemokine receptor 3

Gene type: protein-coding

Location: 3p21.31

dbXrefs: Ensembl:ENSG00000183625 MIM:601268 Vega:OTTHUMG00000133484 UniprotKB:P51677

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.738e-1 (AD) 3.102e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
VCY	0.957
LIPN	0.803
CD1D	0.766
H2AFB2	0.76
TLR8	0.756
ADAMDEC1	0.727
HIST1H2AM	0.718
FPR3	0.716
VENTX	0.705
TLR5	0.687

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SP9	-0.266
PVALB	-0.265
TAC3	-0.262
CPLX3	-0.26
GAD2	-0.259
PCP4L1	-0.258
SLC24A3	-0.257
RPH3A	-0.251
ARSF	-0.245
CAMK2N2	-0.244

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CCR3 mRNA"	19114083
C103303	alitretinoin	alitretinoin results in increased expression of CCR3 mRNA	16712875
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCR3 mRNA	16483693
C118980	antileukinate	antileukinate inhibits the reaction [CCL11 protein binds to CCR3 protein]	12842759
C118980	antileukinate	antileukinate inhibits the reaction [CCL11 protein binds to CCR3 protein]	12842759
D001151	Arsenic	Arsenic affects the expression of CCR3 protein	24675094
D001241	Aspirin	Aspirin results in increased expression of CCR3 mRNA	20022477
D001241	Aspirin	CCR3 gene SNP affects the susceptibility to Aspirin	20485159
D001241	Aspirin	CCR3 SNP affects the susceptibility to Aspirin	18379861
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CCR3 mRNA	26377693
D001685	Biological Factors	Biological Factors promotes the reaction [Ozone results in increased expression of CCR3 mRNA]	21945493
D001685	Biological Factors	Biological Factors results in increased expression of CCR3 mRNA	21945493
D001685	Biological Factors	Ozone promotes the reaction [Biological Factors results in increased expression of CCR3 mRNA]	21945493
C006780	bisphenol A	bisphenol A results in decreased expression of CCR3 mRNA	25181051
D001761	Bleomycin	Bleomycin results in increased expression of CCR3 mRNA	16314464
D001761	Bleomycin	Bleomycin results in increased expression of CCR3 protein	16314464
C006794	brevianamide A	brevianamide A results in increased expression of CCR3 mRNA	19818335
D002087	Butyrates	Butyrates results in increased expression of CCR3 protein	25111027
D002104	Cadmium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of CCR3 mRNA	21481475
C000488	cladosporin	cladosporin results in increased expression of CCR3 mRNA	19818335
C038459	curdlan	curdlan affects the expression of CCR3 mRNA	19904525
C009160	cyclonite	cyclonite results in decreased expression of CCR3 mRNA	25559034
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCR3 mRNA	22968694
C451162	Dermatophagoides pteronyssinus antigen p 1	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of CCR3 mRNA]	28529118
C451162	Dermatophagoides pteronyssinus antigen p 1	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of CCR3 mRNA	28529118
C451162	Dermatophagoides pteronyssinus antigen p 1	Ozone inhibits the reaction [[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of CCR3 mRNA]	28529118
C451163	Dermatophagoides pteronyssinus antigen p 2	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of CCR3 mRNA]	28529118
C451163	Dermatophagoides pteronyssinus antigen p 2	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of CCR3 mRNA	28529118
C451163	Dermatophagoides pteronyssinus antigen p 2	Ozone inhibits the reaction [[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of CCR3 mRNA]	28529118
D003907	Dexamethasone	Dexamethasone results in decreased expression of CCR3 protein	15931867
C027118	didecyldimethylammonium	didecyldimethylammonium results in decreased expression of CCR3 mRNA	19762220
D004041	Dietary Fats	Dietary Fats results in increased expression of CCR3 mRNA	25016146
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCR3 mRNA	23133493
D004137	Dinitrochlorobenzene	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA]	23133493
D004137	Dinitrochlorobenzene	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA]	23133493
D004317	Doxorubicin	Doxorubicin inhibits the reaction [Fungal Polysaccharides results in decreased expression of CCR3 mRNA]	27181935
D004317	Doxorubicin	Doxorubicin results in decreased expression of CCR3 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of CCR3 mRNA]	27181935
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CCR3 mRNA	12538720\|1588563
C032005	fumaric acid	fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein]	23707484
D062610	Fungal Polysaccharides	Doxorubicin inhibits the reaction [Fungal Polysaccharides results in decreased expression of CCR3 mRNA]	27181935
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of CCR3 mRNA]	27181935
D062610	Fungal Polysaccharides	Fungal Polysaccharides results in decreased expression of CCR3 mRNA	27181935
D007213	Indomethacin	Indomethacin results in decreased expression of CCR3 protein	11980903
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR3 mRNA	25613284
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CCR3 mRNA"	23090859
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCR3 mRNA	23999131
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of CCR3 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in decreased expression of CCR3 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of CCR3 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CCR3 mRNA"	25554681
C015380	neoechinulin	neoechinulin results in decreased expression of CCR3 mRNA	19818335
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CCR3 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of CCR3 mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]	11544337
D010126	Ozone	Biological Factors promotes the reaction [Ozone results in increased expression of CCR3 mRNA]	21945493
D010126	Ozone	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of CCR3 mRNA]	28529118
D010126	Ozone	Ozone inhibits the reaction [[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] results in increased expression of CCR3 mRNA]	28529118
D010126	Ozone	Ozone promotes the reaction [Biological Factors results in increased expression of CCR3 mRNA]	21945493
D010126	Ozone	Ozone results in increased expression of CCR3 mRNA	21945493\|2852911
D010126	Ozone	Ozone results in increased expression of CCR3 protein	11777981
C043103	phthalic anhydride	phthalic anhydride results in increased expression of CCR3 mRNA	20219652
D010862	Pilocarpine	Pilocarpine results in decreased expression of CCR3 mRNA	19490431
D010862	Pilocarpine	Pilocarpine results in decreased expression of CCR3 protein	19490431
D010936	Plant Extracts	Plant Extracts results in decreased expression of CCR3 mRNA	12462994
D010936	Plant Extracts	Plant Extracts results in decreased expression of CCR3 protein	12462994
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA]	23133493
D011239	Prednisolone	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA]	23133493
C013221	proanthocyanidin	proanthocyanidin results in decreased expression of CCR3 mRNA	12462994
C013221	proanthocyanidin	proanthocyanidin results in decreased expression of CCR3 protein	12462994
C045950	propiconazole	propiconazole results in increased expression of CCR3 mRNA	21278054
D012402	Rotenone	Rotenone results in decreased expression of CCR3 mRNA	27979718
D012643	Selenium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of CCR3 mRNA	21481475
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CCR3 mRNA	23221170
C017947	sodium arsenite	sodium arsenite results in increased expression of CCR3 mRNA	21911445
D053260	Soot	Soot results in increased expression of CCR3 mRNA	19428942
D016559	Tacrolimus	Tacrolimus results in decreased expression of CCR3 mRNA	15948978
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CCR3 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCR3 mRNA	23999131
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR3 mRNA	25613284
C402696	TMC 120A	TMC 120A results in increased expression of CCR3 mRNA	19818335
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CCR3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CCR3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of CCR3 mRNA	19828696
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CCR3 mRNA	19042947
C009687	wortmannin	wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]	11544337
C031238	zinc sulfide	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of CCR3 mRNA	21481475

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004950	chemokine receptor activity	-	TAS	10415069
GO:0005515	protein binding	-	IPI	23597562
GO:0016493	C-C chemokine receptor activity	-	IBA	21873635
GO:0016493	C-C chemokine receptor activity	-	IEA	-
GO:0019956	chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IDA	11425309

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001938	positive regulation of endothelial cell proliferation	-	IEA	-
GO:0006935	chemotaxis	-	IBA	21873635
GO:0006935	chemotaxis	-	IEA	-
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	IBA	21873635
GO:0006968	cellular defense response	-	TAS	10713092
GO:0007155	cell adhesion	-	TAS	10201960
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	TAS	10201960
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	TAS	9302298
GO:0016032	viral process	-	IEA	-
GO:0019722	calcium-mediated signaling	-	IBA	21873635
GO:0045766	positive regulation of angiogenesis	-	IMP	19525930
GO:0060326	cell chemotaxis	-	IBA	21873635
GO:0070098	chemokine-mediated signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	9302298
GO:0009897	external side of plasma membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-380108	Chemokine receptors bind chemokines	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15526056	An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. (2004 Oct)	Grumelli S	PLoS Med
23566847	CC chemokine receptor-3 as new target for age-related macular degeneration. (2013 Jul 1)	Sharma NK	Gene
16022659	Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells. (2005 Jul)	Mahajan SD	Curr HIV Res
18727632	CD8 chemokine receptors in chronic obstructive pulmonary disease. (2008 Oct)	Smyth LJ	Clin Exp Immunol
12244149	Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor. (2002 Oct 1)	Mahajan SD	J Immunol
19229703	Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. (2009 Feb)	Brozyna S	COPD