Gene: CCR5

1234
CC-CKR-5|CCCKR5|CCR-5|CD195|CKR-5|CKR5|CMKBR5|IDDM22
C-C motif chemokine receptor 5 (gene/pseudogene)
protein-coding
3p21.31
Ensembl:ENSG00000160791 MIM:601373 Vega:OTTHUMG00000133481 UniprotKB:P51681
NG_012637.1
PubMed
0   ANCO-SNPs
CD|OD|ND
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.737e-1 (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIK3AP10.933
RBM470.921
LRRC250.91
GPR650.903
TLR10.9
CCR10.899
LILRB10.895
PARVG0.893
SIGLEC90.892
IKZF10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM179-0.408
BDH1-0.405
KCNIP3-0.399
NEUROD6-0.378
KCNK4-0.377
EXTL1-0.375
ST6GAL2-0.375
BCL11A-0.373
ATP2C2-0.372
MARCH4-0.372

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04835MaravirocSmall Molecule376348-65-1Approved|InvestigationalTarget
DB05501AMD-070Small MoleculeInvestigationalTarget
DB06652VicrivirocSmall Molecule306296-47-9InvestigationalTarget
DB12698IbalizumabBiotechDrug680188-33-4Approved|InvestigationalTarget
DB12960INCB-9471Small Molecule869769-98-2InvestigationalTarget
ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased expression of SOD1 protein]19016906
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]19016906
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased expression of SOD1 protein]19016906
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]19016906
C5138672,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate"2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 protein"16920949
C5138672,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate"2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate binds to and results in increased activity of CCR5 protein"16920949
C5138672,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate"2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 protein"16920949
C5138672,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 protein]"16920949
C5138672,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 protein]"16920949
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA]"21851831
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCR5 mRNA"21851831
C0140242,4,5,2',4',5'-hexachlorobiphenyl"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCR5 mRNA]"21851831
C0453052,4-dinitrofluorobenzene sulfonic acid"2,4-dinitrofluorobenzene sulfonic acid results in increased expression of CCR5 mRNA"17936526
C0306823-chlorophenol3-chlorophenol results in decreased expression of CCR5 mRNA18486366
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [CCL3 protein binds to CCR5 protein]"15644495
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate affects the localization of CCR5 protein]"16920949
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide inhibits the reaction [2,2-dichloro-1-(triphenylphosphonio)vinyl formamide perchlorate results in decreased expression of CCR5 protein]"16920949
C4385834-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide"4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide results in decreased activity of CCR5 protein"15644495
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CCR5 mRNA"21346803
D000082AcetaminophenCCR5 protein results in increased susceptibility to Acetaminophen24770590
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCR5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCR5 mRNA19770486
D0150812-Naphthylamine2-Naphthylamine results in increased expression of CCR5 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCR5 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CCR5 mRNA"22863853
D019380Anti-HIV AgentsAnti-HIV Agents results in decreased expression of CCR5 mRNA10202824
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCR5 mRNA24449571
C499671aplavirocaplaviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]15644495
C499671aplavirocaplaviroc results in decreased activity of CCR5 protein15644495
D001554BenzeneBenzene results in increased expression of CCR5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCR5 mRNA18247414
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CCR5 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCR5 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CCR5 mRNA25181051
D001761BleomycinBleomycin affects the expression of CCR5 mRNA26345256
D001966BromineBromine results in increased expression of CCR5 mRNA18790026
D000074262Canola OilCanola Oil metabolite results in decreased expression of CCR5 mRNA27363782
C005563captaxcaptax results in increased expression of CCR5 mRNA20713136
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CCR5 mRNA23288052
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA]18038451
D000068579CelecoxibCelecoxib results in decreased expression of CCR5 mRNA12902868
D002737ChloropreneChloroprene results in decreased expression of CCR5 mRNA23125180
C418118CI 1044CI 1044 results in increased expression of CCR5 mRNA17569694
D002994ClofibrateClofibrate results in increased expression of CCR5 mRNA17585979
D003042CocaineCocaine results in increased expression of CCR5 protein16204638
D003471CuprizoneCuprizone results in increased expression of CCR5 mRNA27523638
D003520CyclophosphamideCyclophosphamide results in increased expression of CCR5 mRNA15331540
D016572CyclosporineCyclosporine results in increased expression of CCR5 protein21292993
D017373Cyproterone Acetate[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein10770211
D002945CisplatinCisplatin results in increased expression of CCR5 mRNA15814532
D002945Cisplatinpirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA]15814532
D004008DiclofenacDiclofenac results in increased expression of CCR5 mRNA26934552
C027118didecyldimethylammoniumdidecyldimethylammonium results in increased expression of CCR5 mRNA19762220
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCR5 mRNA20713136
D004221DisulfiramDisulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
D004221DisulfiramDisulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]19016906
D004221DisulfiramDisulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]19016906
D004391DustDust results in increased expression of CCR5 mRNA17805423
C046855epostaneepostane promotes the reaction [Dinoprost results in increased expression of CCR5 mRNA]21505051
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein10770211
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CCR5 mRNA12538720|1588563
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCR5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCR5 mRNA15834898
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CCR5 mRNA23649840
D005054EugenolEugenol results in increased expression of CCR5 mRNA17936526|2071313
D005557FormaldehydeFormaldehyde results in decreased expression of CCR5 mRNA23649840
C546771gardiquimodgardiquimod results in increased expression of CCR5 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR5 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of CCR5 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol results in increased expression of CCR5 protein27783115
C004809isopentenyl pyrophosphateisopentenyl pyrophosphate results in decreased expression of CCR5 protein11994442
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCR5 mRNA26387944
D007649KetamineKetamine results in increased expression of CCR5 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCR5 mRNA26918785
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased expression of CCR5 mRNA]"26918785
D008070LipopolysaccharidesCCR5 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]26055553
D008070LipopolysaccharidesCCR5 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]26055553
D008070LipopolysaccharidesCCR5 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]26055553
D008070LipopolysaccharidesCCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides26055553
D008070Lipopolysaccharides[CCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased cleavage of CASP3 protein26055553
D008070Lipopolysaccharides[CCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of ICAM1 protein26055553
C502411maravirocmaraviroc binds to and results in decreased activity of CCR5 protein21128663
C502411maravirocmaraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]15644495
C502411maravirocmaraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein]15644495
C502411maravirocmaraviroc binds to and results in decreased activity of CCR5 protein21539377
C502411maravirocmaraviroc results in decreased activity of CCR5 protein15644495
D008466MechlorethamineMechlorethamine results in increased expression of CCR5 mRNA26273949
D008627Mercuric ChlorideCCR5 protein results in increased susceptibility to Mercuric Chloride12834626
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CCR5 mRNA12834626
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CCR5 protein12834626
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of CCR5 mRNA19564919
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate promotes the reaction [Lipopolysaccharides results in increased expression of CCR5 mRNA]"26918785
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCR5 mRNA23649840
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]16321392
D009020MorphineMorphine results in increased expression of CCR5 protein14644156
C523799MRK 003CCR5 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of CCR5 mRNA18955075
D009151Mustard GasMustard Gas results in decreased expression of CCR5 mRNA27617619
D009183MycotoxinsMycotoxins results in decreased expression of CCR5 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CCR5 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCR5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCR5 mRNA"25554681|2562005
C015380neoechinulinneoechinulin results in decreased expression of CCR5 mRNA19818335
D009532NickelNickel affects the expression of CCR5 mRNA14575637
D009532NickelNickel results in increased expression of CCR5 mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA]14575637
C028007nickel monoxidenickel monoxide results in increased expression of CCR5 mRNA19167457
D009538NicotineNicotine results in increased expression of CCR5 mRNA18247414
D009569Nitric Oxide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
D009569Nitric Oxide[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide19016906
D009569Nitric OxideDisulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
D009569Nitric Oxidewortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
C030110oxaliplatinoxaliplatin results in increased expression of CCR5 mRNA25729387
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CCR5 mRNA]20880076
D010100OxygenOxygen deficiency results in increased expression of CCR5 mRNA20880076
D010100OxygenOxygen deficiency results in increased expression of CCR5 protein20880076
D052638Particulate MatterParticulate Matter results in increased expression of CCR5 mRNA17987463
D052638Particulate MatterParticulate Matter results in increased expression of CCR5 mRNA21906792
D010396PenicillaminePenicillamine results in decreased expression of CCR5 mRNA19575532
D010396PenicillaminePenicillamine results in increased expression of CCR5 mRNA19575532
D010416PentachlorophenolPentachlorophenol results in decreased expression of CCR5 mRNA18486366
C530956PF 232798PF 232798 binds to and results in decreased activity of CCR5 protein21128663
D015232DinoprostoneDinoprostone results in decreased expression of CCR5 mRNA16303787
D015232DinoprostoneDinoprostone results in decreased expression of CCR5 protein16303787
D010634PhenobarbitalPhenobarbital affects the expression of CCR5 mRNA23091169
C006253pirinixic acidpirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA]15814532
D010936Plant ExtractsPlant Extracts results in decreased expression of CCR5 mRNA12462994
C013221proanthocyanidinproanthocyanidin results in decreased expression of CCR5 mRNA12462994
D015237DinoprostDinoprost results in increased expression of CCR5 mRNA21505051
D015237Dinoprostepostane promotes the reaction [Dinoprost results in increased expression of CCR5 mRNA]21505051
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR5 mRNA]28003376
D017382Reactive Oxygen Species2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]19016906
D017382Reactive Oxygen Species[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species19016906
D017382Reactive Oxygen SpeciesDisulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]19016906
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA19564919
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]16321392
D019821SimvastatinSimvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]16321392
D019821SimvastatinSimvastatin results in decreased expression of CCR5 mRNA17112859
D019821SimvastatinSimvastatin results in decreased expression of CCR5 protein17449418
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of CCR5 mRNA17936526
D012999SomanSoman results in increased expression of CCR5 mRNA19281266
D053260SootSoot results in increased expression of CCR5 mRNA22461453
D019311StaurosporineStaurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]12594210
C506967TAK-652TAK-652 binds to and results in decreased activity of CCR5 protein21539377
C119369TAK 779TAK 779 inhibits the reaction [CCL3 protein binds to CCR5 protein]15644495
C119369TAK 779TAK 779 inhibits the reaction [CCL5 protein binds to CCR5 protein]15644495
C119369TAK 779TAK 779 results in decreased expression of CCR5 protein21515370
C119369TAK 779TAK 779 results in decreased activity of CCR5 protein15644495
D013749Tetrachlorodibenzodioxin"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCR5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA17942748
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCR5 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCR5 mRNA18684927|2185183
C009495titanium dioxidetitanium dioxide results in increased expression of CCR5 mRNA21259345|2355797
C402696TMC 120ATMC 120A results in decreased expression of CCR5 mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of CCR5 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCR5 mRNA20133372
D019772TopotecanTopotecan results in increased expression of CCR5 mRNA25729387
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCR5 mRNA16141432
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNA15973123|1798209
D014315TriterpenesTriterpenes analog results in decreased activity of CCR5 protein12372534
C057693troglitazonetroglitazone results in increased expression of CCR5 mRNA28973697
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CCR5 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CCR5 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CCR5 mRNA21906792
C486781vicrivirocvicriviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]15644495
C486781vicrivirocvicriviroc inhibits the reaction [CCL5 protein binds to CCR5 protein]15644495
C486781vicrivirocvicriviroc binds to and results in decreased activity of CCR5 protein21539377
C486781vicrivirocvicriviroc results in decreased activity of CCR5 protein15644495
C025643vinclozolinvinclozolin results in increased expression of CCR5 mRNA23034163
C009687wortmanninwortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]19016906
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0003779actin binding-IDA12421915  
GO:0004435phosphatidylinositol phospholipase C activity-TAS8663314  
GO:0004950chemokine receptor activity-TAS10201901  
GO:0005515protein binding-IPI10816381  12421915  15001559  15660419  15757671  18632580  
23235831  23480650  23597562  24405750  
GO:0015026coreceptor activity-TAS10469138  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016493C-C chemokine receptor activity-IDA10383387  11278962  
GO:0016493C-C chemokine receptor activity-NAS8639485  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IPI8699119  10383387  10679098  
GO:0071791chemokine (C-C motif) ligand 5 binding-IBA21873635  
GO:0071791chemokine (C-C motif) ligand 5 binding-IPI8699119  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEP12032188  
GO:0002407dendritic cell chemotaxis-TAS16621978  
GO:0006816calcium ion transport-IDA8699119  
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS10741397  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0006955immune response-IEA-  
GO:0006968cellular defense response-TAS10201901  
GO:0007166cell surface receptor signaling pathway-TAS8639485  
GO:0007186G-protein coupled receptor signaling pathway-IMP19523456  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS10201901  
GO:0007267cell-cell signaling-IDA10679098  
GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-IDA19523456  
GO:0019064fusion of virus membrane with host plasma membrane-TAS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0019722calcium-mediated signaling-IDA10679098  19523456  
GO:0023052signaling-IEP12032188  
GO:0030260entry into host cell-TAS-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO:0070723response to cholesterol-IMP19523456  
GO:0071222cellular response to lipopolysaccharide-IEP10679098  
GO:2000110negative regulation of macrophage apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS10415069  
GO:0005768endosome-IDA10679098  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10393923  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IDA10383387  10679098  11278962  19523456  
GO:0009986cell surface-IDA10521508  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-173107Binding and entry of HIV virionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6783783Interleukin-10 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17305874Interleukin-24, RANTES and CCR5 gene polymorphisms are not associated with chronic adult periodontitis. (2007 Apr)Savarrio LJ Periodontal Res
16022659Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells. (2005 Jul)Mahajan SDCurr HIV Res
16512757No association between selected candidate gene polymorphisms and severe chronic periodontitis. (2006 Mar)Wohlfahrt JCJ Periodontol
15526056An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. (2004 Oct)Grumelli SPLoS Med
22955940Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. Relationship to clinical risk factors. (2012 Nov)Sagan AThromb Haemost
24155926HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/alpha7-nicotinic acetylcholine receptors. (2013)Gundavarapu SPLoS One
29789655Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. (2018 May 22)Chinnapaiyan SSci Rep
18727632CD8 chemokine receptors in chronic obstructive pulmonary disease. (2008 Oct)Smyth LJClin Exp Immunol
29146238CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward. (2018 Mar)Gonek MBrain Behav Immun
23217400CCR1 and CCR5 expression on inflammatory cells is related to cigarette smoking and chronic obstructive pulmonary disease severity. (2012 Dec)Wang FChin Med J (Engl)
23682308A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities. (2013 May 1)Yuan YMedchemcomm
14560041Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes. (2003 Dec)Ho WZJ Pharmacol Exp Ther
27533781Association of 1166A>C AT1R, -1562C>T MMP-9, ACE I/D, and CCR5Delta32 Polymorphisms with Abdominal Aortic Aneurysm in Croatian Patients. (2016 Oct)Crkvenac Gregorek AGenet Test Mol Biomarkers
24742278Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD. (2014 Apr 18)Stoll PRespir Res
14757849Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. (2004 May)Gekker GJ Pharmacol Exp Ther
16614115Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. (2006 Apr)Duell EJCancer Epidemiol Biomarkers Prev
19229703Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. (2009 Feb)Brozyna SCOPD
22610351CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. (2012 Jul)Shigeta AAm J Physiol Lung Cell Mol Physiol
16055130Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. (2006 May)Pai JKAtherosclerosis
12244149Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor. (2002 Oct 1)Mahajan SDJ Immunol